Antibacterial hydrogel, and preparation method and application thereof

A technology of hydrogel and bacterial cellulose, which is applied in the directions of antibacterial drugs, pharmaceutical formulations, and medical preparations with inactive ingredients, etc. Best sustained antibacterial effect, biotoxicity reduction, biotoxicity reduction effect

Inactive Publication Date: 2020-06-05
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In order to solve the technical problems of poor sustained antibacterial performance and low biotoxicity of antibacterial hydrogels in the prior art, the present invention provides a preparation method of antibacterial hydrogels

Method used

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  • Antibacterial hydrogel, and preparation method and application thereof
  • Antibacterial hydrogel, and preparation method and application thereof
  • Antibacterial hydrogel, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Soak the bacterial cellulose in silver nitrate solution for 20 hours, add the corresponding ligand lipoic acid, stir at room temperature for 15 minutes, then add the corresponding reducing agent sodium borocyanide for reduction, stir at room temperature for 24 hours, the concentration of the silver nitrate solution It is 4mmol / L, and the concentration of described lipoic acid is 20mmol / L, and the concentration range of described sodium borocyanide is 8mmol / L, AgNO (silver nitrate): DHLA (lipoic acid): NaBH The mole of (sodium borohydride) The concentration ratio is 1:5:2, and the final synthesis product is a silver nanocluster-based hydrogel composite AgNCs@BC. The above synthesis schematic diagram is shown in figure 1 shown.

[0030] The Ag NCs and the AgNCs@BC prepared in Example 1 were detected by ultraviolet-visible light absorption spectrum, and the spectrogram is shown in figure 2 ,like figure 2 As shown, the absorption spectrum of AgNCs@BC synthesized in situ...

Embodiment 2

[0037] Soak bacterial cellulose in silver nitrate solution for 20 hours, add corresponding ligand lipoic acid, stir at room temperature for 15 minutes, then add corresponding reducing agent sodium borocyanide for reduction, stir at room temperature for 24 hours, the silver nitrate solution Concentration is 8mmol / L, and the concentration of described lipoic acid is 40mmol / L, and the concentration scope of described sodium borocyanide is 16mmol / L, AgNO3 (silver nitrate): DHLA (lipoic acid): NaBH4 (sodium borohydride) The molar concentration ratio is 1:5:2, and the final synthesis product is a silver nanocluster-based hydrogel composite AgNCs@BC. The above synthesis schematic diagram is shown in figure 1 shown.

[0038] 2.1 The AgNCs@BC obtained in Example 2 was tested for antibacterial activity, and the specific tests were as follows:

[0039] Antibacterial experiment of AgNCs@BC against Staphylococcus aureus:

[0040] Cultivate Staphylococcus aureus in fresh bacterial culture...

Embodiment 3

[0053] Soak bacterial cellulose in silver nitrate solution for 20 hours, add corresponding ligand lipoic acid, stir at room temperature for 15 minutes, then add corresponding reducing agent sodium borocyanide for reduction, stir at room temperature for 24 hours, the silver nitrate solution Concentration is 12mmol / L, and the concentration of described lipoic acid is 60mmol / L, and the concentration range of described sodium borocyanide is 24mmol / L, AgNO3 (silver nitrate): DHLA (lipoic acid): NaBH4 (sodium borohydride) The molar concentration ratio is 1:5:2, and the final synthesis product is AgNCs@BC, a silver nanocluster-based hydrogel composite.

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Abstract

The invention belongs to the technical field of antibacterial hydrogels, and discloses an antibacterial hydrogel, and a preparation method and application thereof. The preparation method comprises thefollowing steps that: bacterial cellulose is soaked in a silver nitrate solution; a corresponding ligand, namely lipoic acid is added; stirring is performed at room temperature; a corresponding reducing agent, namely sodium borohydride is added for reduction; and stirring is performed at room temperature, and finally the product, namely silver nanocluster-based hydrogel compound AgNCs@BC is synthesized. The hydrogel compound AgNCs@BC obtained by the preparation method provided by the invention has relatively good continuous bactericidal activity and relatively low toxicity.

Description

technical field [0001] The invention relates to an antibacterial hydrogel, in particular to an antibacterial hydrogel and its preparation method and application. Background technique [0002] Bacterial infection has been a great threat to public health since ancient times. Among the various antibacterial strategies, the most commonly used method is the application of antibiotics to treat bacterial infections. However, the emergence of antibiotic-resistant pathogens has greatly limited the application of antibiotics, thus forcing researchers to continuously explore new antibacterial drugs. In recent years, silver-based nanomaterials have gradually attracted widespread attention in the industry, and have become an antibacterial agent with high-efficiency antibacterial, non-drug resistance and broad-spectrum bactericidal properties. At present, silver-based nanomaterials have been widely used in scalds, burns, and wounds. and other bacterial infections. However, silver-based...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/38A61K9/06A61K31/717A61K47/38A61P31/04
CPCA61K9/06A61K31/717A61K33/38A61K47/38A61P31/04A61K2300/00
Inventor 袁勋刘勇王珊珊
Owner QINGDAO UNIV OF SCI & TECH
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