Antibacterial agent containing fluorinated alkyl quaternary ammonium salt, and preparation method and application of antibacterial agent

A technology of fluorine-containing alkyl group and fluorine-containing alkyl tertiary amine is applied in the field of antibacterial finishing application, preparation, and fluorine-containing alkyl quaternary ammonium salt silane. The effect of superior antibacterial efficiency

Inactive Publication Date: 2014-02-12
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the disadvantages of complex preparation process in the prior art, to provide a fluorine-containing alkyl quaternary ammonium salt antibacterial finishing agent with high antibacterial efficiency and superior comprehensive performance, a preparation method and its application, and the prepared antibacterial agent It has the characteristics of simple preparation process, easy-to-obtain raw materials, and is suitable for industrial production

Method used

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  • Antibacterial agent containing fluorinated alkyl quaternary ammonium salt, and preparation method and application of antibacterial agent
  • Antibacterial agent containing fluorinated alkyl quaternary ammonium salt, and preparation method and application of antibacterial agent
  • Antibacterial agent containing fluorinated alkyl quaternary ammonium salt, and preparation method and application of antibacterial agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 1, N -Trimethoxysilylpropyl- N, N -Synthesis of dimethyltridecafluorooctyl ammonium chloride

[0037] (1) N, N-Dimethyl-tridecafluorooctyl tertiary amine

[0038] Add 32.79g of 33% dimethylamine aqueous solution and 6.4g of sodium hydroxide into a three-necked flask equipped with magnetic stirring and a thermometer, add 34.16g of tridecafluorooctyl bromide dropwise after heating to 70°C, and continue the reaction after the dropwise addition 24h. After the reaction was completed, ethyl acetate was added to extract 50 mL x 3 times, the extracts were combined and washed with water 40 mL x 3 times. Add 3.5 g of anhydrous sodium sulfate to the oil phase and dry it for 12 hours, then filter off the desiccant sodium sulfate, and remove the extractant by rotary evaporation under reduced pressure to obtain 13.56 g of a light yellow transparent product.

[0039] (2) Quaternization

[0040] In a three-neck flask equipped with a magnetic stirrer and a thermometer N, N - 13.5...

Embodiment 2

[0058] 1, N -Trimethoxysilylpropyl- N, N -Synthesis of Diethyltridecafluorooctyl Ammonium Chloride

[0059] (1) N, N -Diethyl-tridecafluorooctyl tertiary amine

[0060] Add 17.55 g of diethylamine and 6.4 g of sodium hydroxide into a three-necked flask equipped with magnetic stirring and a thermometer. After heating to 70° C., add 34.16 g of tridecafluorooctylbromide dropwise, and continue the reaction for 24 hours after the addition is complete. After the reaction was completed, ethyl acetate was added to extract 50 mL x 3 times, the extracts were combined and washed with water 40 mL x 3 times. The oil phase was dried by adding 3.5 g of anhydrous sodium sulfate for 12 hours, the desiccant sodium sulfate was filtered off, and the filtrate was rotary evaporated under reduced pressure to remove the solvent to obtain 9.96 g of a light yellow transparent product.

[0061] (2) Quaternization

[0062] In a three-neck flask equipped with a magnetic stirrer and a thermometer N, ...

Embodiment 3

[0069] 1, N -Trimethoxysilylpropyl- N, N -Synthesis of Dibutyltridecafluorooctylammonium Bromide

[0070] (1) N, N -Dibutyl-tridecafluorooctyl tertiary amine

[0071] Add 12.38g of di-n-butylamine and 3.84g of sodium hydroxide into a three-necked flask equipped with magnetic stirring and a thermometer, heat the oil bath to 70°C, add 20.50g of tridecafluorooctyl bromide dropwise, and continue the reaction for 24 hours after the addition is complete . After the reaction, add 30 mL of ethyl acetate to extract x 3 times, combine the extracts, add deionized water to wash 20 mL x 3 times, add 2.0 g of anhydrous sodium sulfate to the oil phase and dry for 12 h, filter off the desiccant, and remove the filtrate by rotary evaporation under reduced pressure solvent to obtain 8.16 g of a light yellow transparent product.

[0072] (2) Quaternization

[0073] In a three-neck flask equipped with a magnetic stirrer and a thermometer N, N - 8.16 g of dibutyl-tridecafluorooctyl tertiary...

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Abstract

The invention discloses an antibacterial agent containing fluorinated alkyl quaternary ammonium salt, and a preparation method and an application of the antibacterial agent. The method comprises the steps that fluorinated alkyl tertiary amine is prepared by a substitution reaction, and then N-trialkoxysilane propyl-N,N-dialkyl tridecafluoro octyl ammonium halide is obtained by a quaterisation reaction. Prepared fluorinated alkyl quaternary ammonium salt serves as an antibacterial finishing agent, and has better antibacterial efficiency compared with non-fluorinated alkyl quaternary ammonium salt; a preparation reaction condition of the antibacterial agent is mild; a preparation technology is simple and convenient; raw materials are easy to obtain; industrial production, popularization and the application are facilitated; the antibacterial agent has a very high-efficiency antibacterial effect and excellent comprehensive finishing property for antibacterial finishing of fabric.

Description

technical field [0001] The invention relates to a fluorine-containing alkyl quaternary ammonium salt antibacterial agent, a preparation method and application thereof, in particular to a fluorine-containing alkyl quaternary ammonium salt silane, a preparation method and an antibacterial finishing application to fabrics. Background technique [0002] Among the organic antibacterial agents that have been extensively researched and applied, quaternary ammonium antibacterial agents are the most well-known species, including mono-alkyl quaternary ammonium salts, di-alkyl chain quaternary ammonium salts, and Gemini-type quaternary ammonium salts. And various modified quaternary ammonium salts and polymer quaternary ammonium salts and many other types. Quaternary ammonium salt antibacterial agents are adsorbed to the surface of negatively charged bacterial cells by positively charged nitrogen cations, and then their long alkyl chains penetrate deep into the hydrophobic cell membran...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D06M13/513C07F7/18
Inventor 李战雄蔡露袁艳华
Owner SUZHOU UNIV
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