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Rare earth doped nanoprobe, preparation and new coronavirus detection probe

A nano-probe and rare earth doping technology, which is applied in the direction of measuring devices, instruments, and analytical materials, can solve the problems of insufficient sensitivity and achieve the effects of small background interference, improved efficiency, and strong stability

Active Publication Date: 2020-06-05
厦门奥德生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, most of the detection methods for novel coronavirus IgM / IgG antibodies on the market are colloidal gold method, but the colloidal gold method can only be used for qualitative detection, and the sensitivity is still insufficient.

Method used

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  • Rare earth doped nanoprobe, preparation and new coronavirus detection probe

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Step 1. Preparation of praseodymium-doped lutetium fluoride sodium nucleus:

[0029] In a 100mL three-necked round-bottom flask, add 4.5mL oleic acid and 12.5mL 1-octadecene, then add 0.3998mmol lutetium acetate and 0.0002mmol praseodymium acetate in a molar ratio, mix and stir at room temperature, vacuumize, and then heat up to 120°C, react for 20 minutes, then raise the temperature to 160°C, react for 10 minutes to obtain a transparent solution; naturally cool to 50°C, release the vacuum, add 1mmol NaOH and 1.6mmol ammonium fluoride methanol mixed solution, react for 30min; heat up to 100°C , pumped and ventilated 3 times, fed nitrogen, heated to 300°C, reacted for 1.5 hours, centrifuged at 6000rpm, washed 3 times with cyclohexane-ethanol mixture, dispersed in cyclohexane, and synthesized NaLu 0.9995 f 4 :Pr 0.0005 . The rare earth luminescent material, especially the rare earth fluoride luminescent material selected in the present invention has lower phonon energy...

Embodiment 2

[0033] Step 1. Preparation of praseodymium-doped lutetium fluoride sodium nucleus:

[0034] In a 100mL three-necked round-bottom flask, add 4.5mL oleic acid and 12.5mL 1-octadecene, then add 0.38mmol lutetium acetate and 0.02mmol praseodymium acetate in a molar ratio, mix and stir at room temperature, vacuumize, and then heat up to 120°C, react for 20 minutes, then raise the temperature to 160°C, react for 10 minutes to obtain a transparent solution; naturally cool to 50°C, release the vacuum, add 1mmol NaOH and 1.6mmol ammonium fluoride methanol mixed solution, react for 30min; heat up to 100°C , pumped and ventilated 3 times, fed nitrogen, heated to 300°C, reacted for 1.5 hours, centrifuged at 6000rpm, washed 3 times with cyclohexane-ethanol mixture, dispersed in cyclohexane, and synthesized NaLu 0.95 f 4 :Pr 0.05 . The rare earth luminescent material, especially the rare earth fluoride luminescent material selected in the present invention has lower phonon energy, which ...

Embodiment 3

[0038] Step 1. Preparation of praseodymium-doped lutetium fluoride sodium nucleus:

[0039] In a 100mL three-necked round-bottom flask, add 4.5mL oleic acid and 12.5mL 1-octadecene, then add 0.398mmol lutetium nitrate and 0.002mmol praseodymium nitrate in a molar ratio, mix and stir at room temperature, vacuumize, and then heat up to 120°C, react for 20 minutes, then raise the temperature to 160°C, react for 10 minutes to obtain a transparent solution; naturally cool to 50°C, release the vacuum, add 1mmol NaOH and 1.6mmol ammonium fluoride methanol mixed solution, react for 30min; heat up to 100°C , pumped and ventilated 3 times, fed nitrogen, heated to 300°C, reacted for 1.5 hours, centrifuged at 6000rpm, washed 3 times with cyclohexane-ethanol mixture, dispersed in cyclohexane, and synthesized NaLu 0.995 f 4 :Pr 0.005 . The rare earth luminescent material, especially the rare earth fluoride luminescent material selected in the present invention has lower phonon energy, wh...

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Abstract

The invention discloses a rare earth doped nanoprobe, preparation and a new coronavirus detection probe. The rare earth doped nanoprobe is a praseodymium doped sodium lutetium fluoride coated sodium yttrium fluoride with a core-shell structure, wherein the formula of the rare earth doped nanoprobe is NaLu1-xF4:Prx@NaYF4, wherein the NaLu1-xF4 is a matrix, and the doping ion is praseodymium; the colon refers to praseodymium doping, wherein x is the doping molar ratio of rare earth ions, and the range of x is 0.0005-0.05; the NaYF4 is a shell layer, and the symbol @ refers to that NaYF4 coats the surface of NaLu1-xF4:Prx. According to the invention, rare earth fluoride is used as a matrix and different rare earth ions are doped, so that the praseodymium-doped lutetium sodium fluoride nanometer probe with high performance is synthesized; the doping of lutetium and the doping proportion further reduce phonon energy of the matrix and improve the efficiency of energy conversion, and the doping of praseodymium can utilize the luminescence of praseodymium at about 610 nm to facilitate the detection, so that the rare earth nanoprobe with strong photochemical property stability and long luminescence service life is prepared.

Description

technical field [0001] The invention relates to a rare earth-doped nano-probe, its preparation and a new coronavirus detection probe. Background technique [0002] In the latest "New Coronavirus Pneumonia Diagnosis and Treatment Program (Trial Seventh Edition)", serological testing was proposed, which clarified the significance of the detection of new coronavirus-specific IgG and IgM antibodies in serological examination. Positive serum 2019-nCoV-specific IgM antibodies and IgG antibodies were added to the protocol; serum 2019-nCoV-specific IgG antibodies changed from negative to positive or the recovery period was 4 times or more higher than the acute period. [0003] At present, most of the detection methods for novel coronavirus IgM / IgG antibodies on the market are colloidal gold method, but the colloidal gold method can only perform qualitative detection, and the sensitivity is still insufficient. Compared with the colloidal gold method, the rare earth nanoprobe-based m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/85G01N21/64G01N33/569
CPCC09K11/7773C09K11/02G01N21/6428G01N21/645G01N33/56983G01N2333/165
Inventor 张云宋良明丽艳张肖
Owner 厦门奥德生物科技有限公司
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