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Degradable anti-infection and anti-calculus fe-cu alloys suitable for urinary implant materials

An implant material, anti-infection technology, applied in medical science, prosthesis, etc., can solve the problems of urinary tract infection and calculus, increase retrograde infection, disrupt the normal operation system, etc., to inhibit adhesion and proliferation, prevent calculus formation. , the effect of strong antibacterial function

Active Publication Date: 2021-10-22
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Interventional treatment with implants such as staples and stents can make the operation efficient and precise. However, urinary tract infections and stones caused by implants are very difficult, and the incidence rate remains high, which brings huge physical pain and heavy burden to patients. Economic burden, while limiting widespread use of implantable devices
[0003] Bacterial infection caused by implants is one of the key factors leading to the failure of surgery. Foreign objects disturb the normal operation system in the body, easily destroy the body's defense barrier, affect the normal flushing effect of the urinary tract on bacteria, and increase the chance of retrograde infection

Method used

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  • Degradable anti-infection and anti-calculus fe-cu alloys suitable for urinary implant materials
  • Degradable anti-infection and anti-calculus fe-cu alloys suitable for urinary implant materials
  • Degradable anti-infection and anti-calculus fe-cu alloys suitable for urinary implant materials

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] In this embodiment, the composition of the Fe-0.5Cu alloy is: 0.5% Cu, and the balance is Fe.

[0040] Preparation method: The above-mentioned composition alloy is made into an ingot by vacuum induction melting, and after being kept at 1000°C for 2 hours, it is forged into a rod of Φ20mm, processed into a rod of Φ6mm~10mm by extrusion or swaging, and processed into a rod of Φ0. 2 ~ 0.6mm wire, prepared into staples (YY / T 0245-2008). During the drawing process, supplemented by heat treatment, the treatment process is 1000 ° C under vacuum atmosphere for 1 hour, water quenching and cooling to room temperature.

[0041] Tensile properties (GB / T 228-2002): The tensile strength is 200MPa, the yield strength is 130MPa, and the elongation is 45%.

[0042] Antibacterial properties (GB / T 2591): Sterilization rate for Staphylococcus aureus: 98%; Sterilization rate for Mirabilis proteus: 95%.

[0043] Anti-stone performance: stone rate <5%.

[0044] Degradation rate (artificial...

Embodiment 2

[0047] In this embodiment, the composition of the Fe-1Cu-25Mn alloy is: 1% Cu, 25% Mn, and the balance is Fe.

[0048] Preparation method: The above-mentioned composition alloy is made into an ingot by vacuum induction melting, and after being kept at 1000°C for 2 hours, it is forged into a rod of Φ20mm, processed into a rod of Φ6mm~10mm by extrusion or swaging, and processed into a rod of Φ0. 2-1mm wire, prepared into staples (YY / T 0245-2008). During the drawing process, supplemented by heat treatment, the treatment process is 1000 ° C under vacuum atmosphere for 1 hour, then water quenching.

[0049] Tensile properties (GB / T 228-2002): The tensile strength is 820MPa, the yield strength is 260MPa, and the elongation is 65%.

[0050] Antibacterial properties (GB / T 2591): Sterilization rate for Staphylococcus aureus: 99%; Sterilization rate for Mirabilis proteus: 96%.

[0051] Anti-stone performance: stone rate <5%.

[0052] Degradation rate (artificial urine, soaked for 30 ...

Embodiment 3

[0055] In this embodiment, the composition of the Fe-2Cu-20Mn-1C alloy is: 2% Cu, 20% Mn, 1% C, and the balance is Fe.

[0056] Preparation method: The above composition alloy is made into an ingot by vacuum induction melting, and after being kept at 980°C for 3 hours, it is forged into a rod of Φ20mm, processed into a rod of Φ6mm~10mm by extrusion or swaging, and processed into a rod of Φ0. 2-1mm wire, prepared into staples (YY / T 0245-2008). During the drawing process, supplemented by heat treatment, the treatment process is 950 ° C for 1.5 hours in a vacuum atmosphere, and then water quenching.

[0057] Tensile properties (GB / T 228-2002): The tensile strength is 1050MPa, the yield strength is 360MPa, and the elongation is 70%.

[0058] Antibacterial properties (GB / T 2591): Sterilization rate for Staphylococcus aureus: 99%; Sterilization rate for Mirabilis proteus: 99%.

[0059] Anti-stone performance: stone rate <5%.

[0060] Degradation rate (artificial urine, soaked for...

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Abstract

The invention belongs to the field of biomedical materials, in particular to a degradable anti-infection and anti-calculus Fe-Cu alloy suitable for urinary implant materials. The alloy composition and weight percentage are as follows: Cu is 0.2%-5.0%, Mn is 0-35%, C is 0-1.5%, N is 0-0.6%, and the balance is Fe. Aiming at the problems of non-degradable, susceptible to infection and easy formation of stones in urinary tract implants, the sterilization effect is achieved by releasing Cu ions, and the formation of bacterial biofilm on the surface is simultaneously inhibited through surface degradation and sterilization, thereby preventing bacterial film as the center. At the same time, Mn, C, and N elements can be selectively added to control the austenitization and degradation rate of the alloy, so that the alloy can be degraded and metabolized in the biological environment in vivo after surgery, without the need for secondary surgery. Therefore, it can effectively solve the problems of urinary tract implant infection and calculus, can solve practical problems in clinical, meet the current advanced medical concepts and human needs, and is a new direction for the development of urinary implant materials.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a degradable anti-infection and anti-calculus Fe-Cu alloy suitable for urinary implant materials. Background technique [0002] A variety of urinary tract lesions in the urinary system require tissue resection followed by urethral passage reconstruction. At present, the ureter-bladder anastomosis not only requires high technical requirements, but also prone to urinary fistula or anastomotic stenosis. A new technique is the use of staples. In addition, ureteral obstruction usually requires the introduction of a stent to resolve the stricture. Interventional treatment with implants such as staples and stents can make the operation efficient and precise. However, urinary tract infections and stones caused by implants are very difficult, and the incidence rate remains high, which brings huge physical pain and heavy burden to patients. Economic burden, while limiting the widespre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C22C38/04C22C38/16A61L27/04B21C37/06
CPCA61L27/042B21C37/06C22C38/001C22C38/04C22C38/16
Inventor 马政谭丽丽杨柯
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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