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Antibacterial material for pediatric pneumonia protection and manufacturing method thereof

The technology of an antibacterial material and a manufacturing method is applied in the field of antibacterial materials for pediatric pneumonia protection and its manufacturing field, which can solve the problems of insufficient biosafety, fast release speed, short antibacterial time period, etc., achieve safe and long-term antibacterial effect, and ensure good health. , the effect of excellent antibacterial properties

Inactive Publication Date: 2020-06-05
HENAN PROVINCE HOSPITAL OF TCM THE SECOND AFFILIATED HOSPITAL OF HENAN UNIV OF TCM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this antibacterial material contains a large amount of heavy metals such as silver, copper, and dysprosium, and its release rate is fast, which is easy to form excessive release in the early stage. Not only the antibacterial time is short, but also poses a potential threat to children, and the biological safety is insufficient.

Method used

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  • Antibacterial material for pediatric pneumonia protection and manufacturing method thereof
  • Antibacterial material for pediatric pneumonia protection and manufacturing method thereof
  • Antibacterial material for pediatric pneumonia protection and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] see figure 1 , the present embodiment provides a kind of manufacture method of antibacterial material for pediatric pneumonia protection, comprising the steps of:

[0045] S1. Dissolve 0.01mol of cetyltrimethylammonium bromide in 200mL of 50% ethanol solution, and then sequentially add 25% ammonia solution prepared by 0.0025mol of ammonia and deionized water into the solution , 0.02mol ethyl orthosilicate and 0.01mol 3-aminopropyltriethoxysilane, stirred at room temperature for 12 hours, then heated up to 80°C and stirred for 24 hours, after the solution was naturally cooled to room temperature, firstly at pH 6 Dialyzed in the acetic acid-ethanol solution for 24 hours to remove cetyltrimethylammonium bromide, and then dialyzed in deionized water for 24 hours, and freeze-dried the obtained solution at a vacuum degree of 5 Pa and a temperature of -20°C for 24 hours. Aminated porous silica nanoparticles are obtained;

[0046] S2. Disperse the aminated porous silica nanop...

Embodiment 2～5 and comparative example 1

[0054] Embodiments 2-5 and Comparative Example 1 respectively provide a method for manufacturing an antibacterial material for pediatric pneumonia protection. Compared with Example 1, the difference is that Embodiments 2-5 only change the substances of each raw material in step S1 The ratio of the amount or the mass ratio of silver nitrate and aminated porous silica nanoparticles in step S2, comparative example 1 only changes the dosage of 3-aminopropyl triethoxysilane into 0 in step S1, and the rest The steps are all the same as those in Example 1, and will not be repeated here; the corresponding parameters corresponding to steps S1 and S2 in each example and comparative example are shown in Table 2.

[0055] Table 2 Parameters corresponding to Step S1 and Step S2 in Examples 2-5 and Comparative Example 1

[0056]

[0057] According to the same method as Example 1, the antibacterial properties of the antibacterial materials for pediatric pneumonia protection manufactured i...

Embodiment 6～9 and comparative example 2

[0063] Embodiments 6-9 and Comparative Example 2 respectively provide a method for the manufacture of antibacterial materials for pediatric pneumonia protection. Compared with Example 1, the difference is that Embodiments 6-9 only change the cellulose acetate and The mass ratio of methacryloyloxyethyltrimethylammonium chloride or the reaction temperature of quaternization reaction, comparative example 2 only changes the dosage of methacryloyloxyethyltrimethylammonium chloride in step S3 is 0, and the rest of the steps are consistent with that of Example 1, and will not be repeated here; the corresponding parameters corresponding to step S3 in each example and comparative example are shown in Table 4.

[0064] Table 4 Parameters corresponding to Step S3 in Examples 6-9 and Comparative Example 2

[0065]

[0066]

[0067] According to the same method as Example 1, the antibacterial properties of the antibacterial materials for pediatric pneumonia protection manufactured in...

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Abstract

The invention discloses an antibacterial material for pediatric pneumonia protection and a manufacturing method thereof. Aminated porous silicon dioxide nanoparticles are prepared and modified by silver ions, the silver-loaded porous silicon dioxide nanoparticles are embedded in quaternized modified cellulose acetate, and the antibacterial material for pediatric pneumonia protection is manufactured through an electrostatic spinning technology. In this way, abundant amino groups in the aminated porous silicon dioxide nanoparticles can be used as the active sites, and tight complexing of the silver ions is realized; and by utilizing a large amount of quaternary ammonium groups grafted on the cellulose acetate and the nano silver, the release rate of silver is reduced on the basis of ensuringthe antibacterial effect, so that the prepared antibacterial material has excellent antibacterial performance and safe and long-acting antibacterial effect. The manufacturing method of the antibacterial material for the pediatric pneumonia protection provided by the invention is easy to operate, high in controllability, capable of meeting the requirements of practical application and relatively high in application value.

Description

technical field [0001] The invention relates to the technical field of antibacterial materials, in particular to an antibacterial material for pediatric pneumonia protection and a manufacturing method thereof. Background technique [0002] Pneumonia is a common infectious disease in childhood and the most common cause of hospitalization in children. According to different pathogenic bacteria, it can be divided into bacterial pneumonia, viral pneumonia, mycoplasma pneumonia, chlamydia pneumonia and fungal pneumonia, etc. Among them, bacterial pneumonia is the most common pneumonia, accounting for about 80% of pneumonia, and bacterial pneumonia Bacterial pathogens such as Streptococcus pneumoniae and Staphylococcus aureus in acute pneumonia are important factors that cause increased morbidity and mortality. Therefore, in order to protect children's health and avoid pneumonia caused by bacterial infection, it is necessary to effectively protect children, and how to manufacture...

Claims

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Application Information

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IPC IPC(8): D01F2/28D01F1/10
CPCD01F1/103D01F2/28
Inventor 王天琦
Owner HENAN PROVINCE HOSPITAL OF TCM THE SECOND AFFILIATED HOSPITAL OF HENAN UNIV OF TCM
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