Method of reducing insulin dosage in diabetic patients using stem cell therapy

Abstract

The invention discloses a method for reducing insulin dosage of a diabetic patient by applying stem cell therapy. According to the method, the bone marrow mesenchymal stem cells in the body of a diabetic patient are separated and amplified; mature bone marrow mesenchymal stem cells are cultured; then, the mesenchymal stem cells are transfused and injected back to the diabetic patient; the dosage of insulin for the diabetic patient is reduced; intravenous injection is adopted in a reinfusion mode, the average quantity of the mesenchymal stem cells injected into each patient each time is 11.2 *10 < 10 >; the injection is carried out once every 10 days, the dosage of insulin is gradually reduced for a diabetic patient after each time of reinfusion, the total number of times of reinfusion is8-10, and the number of times of reinfusion is increased according to the illness state of the diabetic patient until the diabetic patient do not need insulin. The stem cell therapy makes a breakthrough in reducing the insulin dosage of diabetic patients, stem cell transplantation experiments are carried out on 15 diabetic patients, and results show that 13 patients get rid of insulin dependence.

Description

technical field [0001] The invention belongs to the technical field of methods for improving diabetes, and in particular relates to a method for reducing insulin dosage of diabetic patients by applying stem cell therapy. Background technique [0002] Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia caused by defective insulin secretion or its biological action, or both. Differential diagnosis methods for diabetes include: 1. Liver disease: Patients with liver cirrhosis often have abnormal glucose metabolism. Typically, fasting blood sugar is normal or low, and postprandial blood sugar rises rapidly, and fasting blood sugar can also increase in the elderly. 2. Chronic renal insufficiency: Mild abnormal glucose metabolism may occur. 3. Stress state: Many stress states such as heart and cerebrovascular accidents, acute infection, trauma, and surgery may cause a transient increase in blood sugar, which can be recovered within 1 to 2 weeks after ...

AI Technical Summary

Problems solved by technology

4. A variety of endocrine diseases: such as acromegaly, Cushing's syndrome, hyperthyroidism, pheochromocytoma, and glucagonoma can cause secondary diabetes. In addition to elevated blood sugar, there are other characteristic manifestations. Not difficult to identify

2. Insulin edema is prone to occur: For diabetics whose blood sugar is not controlled, water and sodium retention will occur at the beginning of insulin use due to the lack of water and other elements in the body, especially after blood sugar is controlled. Within 6 days, it is easy to have edema of the extremities

3. Hypoglycemia reaction: some diabetics have not adjusted the amount of insulin used during long-term insulin injection, or their blood sugar has been stabilized, and they also need to exercise and diet control at ordinary times. If they continue to inject at this time Insulin can easily lead to hypoglycemia, and when hypoglycemia occurs, it is easy to put the patient's life in danger

4. It is easy to cause subcutaneous fat hyperplasia: long-term injection of insulin will easily lead to hyperplasia of subcutaneous fat, especially for some diabetics who inject one part for a long time, when subcutaneous fat hyperplasia occurs, it will not only reduce the effect of insulin, but also prone to other symptoms Some skin hazards, so people with diabetes should know that if they inject insulin for a long time, they should pay attention to the replacement of the injection site in turn

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