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Long-acting anticoagulant coating for in-vitro membrane oxygenation device (ECMO) and preparation method thereof

An anticoagulant and oxygenation technology, applied in the field of biomedical engineering functional materials, can solve the problems of loss of anticoagulant activity of heparin units, reduction of heparin surface assembly amount and activity, and limitation of clinical long-term anticoagulant effect, so as to benefit endothelial Enhanced, increased stability, and long-lasting effects

Pending Publication Date: 2020-06-19
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method still has the following disadvantages: 1) The heparin is pre-formylated, which will inevitably lead to the loss of the anticoagulant activity of the heparin unit; The assembly amount and activity are greatly reduced, which limits its clinical long-term anticoagulant effect to a certain extent

Method used

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  • Long-acting anticoagulant coating for in-vitro membrane oxygenation device (ECMO) and preparation method thereof
  • Long-acting anticoagulant coating for in-vitro membrane oxygenation device (ECMO) and preparation method thereof

Examples

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Effect test

Embodiment 1

[0030] A method for preparing a long-acting anticoagulant coating that can be used in the whole system of an extracorporeal membrane oxygenation device (ECMO), is prepared by the principle of film formation-crosslinking-film formation, and specifically includes the following steps:

[0031] (1) The polyurethane catheter of the ECMO device is pretreated with an aminosilane coupling agent, so that the surface of the material carries amino functional groups;

[0032] (2) Put the above material in 3 mg / mL heparin buffer solution (pH5.5), react for 10 minutes, wash with deionized water for 3 times, then place the material in 0.5 mg / mL polyethyleneimine solution Medium (pH6), after reacting for 10min, wash with deionized water for 3 times and put it into 3mg / mL heparin buffer solution (pH5.5) again to complete a cycle step, then use it as the base material, repeat this step 4 Coating A is obtained after the times;

[0033] (3) The obtained coating A is treated with 0.2%wt glutarald...

Embodiment 2

[0036] A method for preparing a long-acting anticoagulant coating that can be used in the whole system of an extracorporeal membrane oxygenation device (ECMO), is prepared by the principle of film formation-crosslinking-film formation, and specifically includes the following steps:

[0037] (1) The neodymium alloy of the centrifugal pump head of the ECMO device is pretreated by ammonia plasma, so that the surface of the material carries amino functional groups;

[0038] (2) above-mentioned material is placed in the heparin buffer solution (pH6) of 0.5mg / mL, use after reaction 20min, wash 3 times with deionized water, then material is placed in the chitosan solution of 0.2mg / mL ( pH 6), after reacting for 10 minutes, washed with deionized water for 3 times, and then placed in 0.5 mg / mL heparin buffer solution (pH 6) to complete a cycle step, and then use it as the base material, repeat this step 5 times to obtain coating A;

[0039] (3) Gained coating A is treated with 0.2%wt ...

Embodiment 3

[0042]A method for preparing a long-acting anticoagulant coating that can be used in the whole system of an extracorporeal membrane oxygenation device (ECMO), is prepared by the principle of film formation-crosslinking-film formation, and specifically includes the following steps:

[0043] (1) The polyurethane catheter of the ECMO device is pretreated with an aminosilane coupling agent, so that the surface of the material carries amino functional groups;

[0044] (2) Put the above material in 5mg / mL heparin buffer solution (pH7), react for 30min, wash with deionized water for 3 times, then place the material in 1mg / mL polylysine solution (pH6 ), after reacting for 10 minutes, washed with deionized water for 3 times and then placed in 5 mg / mL heparin buffer solution (pH 7) to complete a cycle step, then use it as the base material, repeat this step 5 times to obtain a coating A;

[0045] (3) The genipin of gained coating A is processed 10min with 0.3%wt;

[0046] (4) Using co...

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Abstract

The invention discloses a long-acting anticoagulant coating for an in-vitro membrane oxygenation device (ECMO) and a preparation method thereof. The method comprises the following steps of: (1) enabling a pretreated substrate material to carry amino groups; (2) putting the material obtained in the step (1) into a heparin solution for reaction, then putting the material into a polycation electrolyte solution for continuous reaction, and finally putting the material into the heparin solution for reaction; (3) taking the product obtained in the step (2) as a material, repeating the operation in the step (2) for 3-6 times, and then treating the material with a cross-linking agent; and (4) taking the product obtained in the step (3) as a material, and repeating the operation in the step (2) andthe step (3) for 1-3 times. Heparin is introduced into the coating in a stepped electrostatic combination mode, so that the activity can be well kept; and through post-treatment of the multi-step cross-linking agent, the stability of the coating is improved, and the long-acting effect of the heparin can be maintained.

Description

technical field [0001] The invention belongs to the technical field of biomedical engineering functional materials, and in particular relates to a long-acting anticoagulant coating for the whole system of an extracorporeal membrane oxygenation device and a preparation method thereof. Background technique [0002] Blood-contact materials and devices, such as cardiovascular stents, heart valves, blood-contact catheters, etc., often face the risk of thrombosis. In addition, as Class III medical devices, long-term implant interventions are bound to be accompanied by continuous inflammatory stimuli, which can easily lead to calcification , hyperplasia, etc., causing device failure. Among the many blood contact devices, extracorporeal membrane oxygenation (Extracorporeal Membrane Oxygenation, ECMO) plays a pivotal role. [0003] ECMO was first applied in the treatment of cardiogenic heart disease in cardiac surgery, and was gradually extended to the intensive care and respiratory...

Claims

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Application Information

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IPC IPC(8): A61L33/08A61L33/00A61L33/06
CPCA61L33/0011A61L33/068A61L33/08A61L2420/02A61L2420/08C08L79/02
Inventor 王云兵罗日方杨立张凡军王京玉
Owner SICHUAN UNIV
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