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Astaxanthin nano-emulsion with good blending properties, and preparation method for astaxanthin nano-emulsion

A technology of nanoemulsion and astaxanthin, which is applied to medical preparations with no active ingredients, medical preparations containing active ingredients, dairy products, etc., can solve problems such as emulsifier poisoning, complicated process, and unclear application characteristics. To achieve the effect of improving the stability of brewing

Pending Publication Date: 2020-06-26
INNOBIO CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN107874257 A In addition to the use of organic solvents, it also requires four consecutive homogenizations of different pressures from low to high, and the process is complex
[0008] Patent CN107105694 A metastable translucent spice nanoemulsion and its preparation method, using 0.1-20% emulsifier, if the amount is too large, it may easily cause problems such as emulsifier poisoning, and obtain products through different levels of emulsifiers and homogeneous pressure, process complex
[0009] In view of the shortcomings of the above various emulsion formulations, complex preparation process, difficult industrialization, and unclear application characteristics, a new formulation and preparation method of astaxanthin emulsion is needed to solve the above problems

Method used

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  • Astaxanthin nano-emulsion with good blending properties, and preparation method for astaxanthin nano-emulsion
  • Astaxanthin nano-emulsion with good blending properties, and preparation method for astaxanthin nano-emulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1: Effect of diluent on emulsion formation

[0036] (1) Mix 30 g of octenyl succinic acid mono-arabic gum ester, 25 g of glucose syrup and 45 g of glycerin and stir evenly, add 10 g of astaxanthin, 0.1 g of mixed tocopherol, stir, the viscosity of the emulsion is 10000 mcp.s, the state is viscous and not Homogeneous, and could not be homogenized to obtain an emulsion.

[0037](2) Mix 30 g of octenyl succinic acid monoarabic gum ester, 25 g of glucose syrup and 45 g of water and stir evenly, add 10 g of astaxanthin, 0.1 g of mixed tocopherol, stir, the emulsion viscosity is 2000 mcp.s, the state is uniform, and the state is uniform at 100 Mpa. After the astaxanthin emulsion was obtained, its particle size was 3.5 microns; its ZETA potential was -15mV (the system was considered to be stable when the absolute value was greater than 30), and delamination appeared when placed at 37°C for 3 days.

[0038] (3) Mix 30 g of octenyl succinic acid mono-arabic gum ester, 2...

Embodiment 2

[0041] Example 2: Screening of Embedding Wall and Filling Materials

[0042] Mix 100 g of octenyl succinic acid monoarabic gum ester, 80 g of filler material with 450 g of water and stir evenly, add 100 g of astaxanthin, 1 g of mixed tocopherol, and 2 g of potassium sorbate, stir and dissolve, and homogenize at 60 Mpa to obtain astaxanthin emulsion , different filling materials, the obtained emulsion index is shown in Table 1 below:

[0043] Table 1. Emulsion Specifications

[0044]

[0045] (7) 100 g of sodium starch octenyl succinate (a kind of modified starch), 80 g of erythritol and 450 g of water were mixed and stirred evenly, 100 g of astaxanthin was added, 5 g of mixed tocopherols, and 0.5 g of potassium sorbate were stirred. Dissolved and homogenized at 45Mpa to obtain astaxanthin emulsion with a particle size of 8.3 microns; its ZETA potential was 21mV (the system was considered stable when the absolute value was greater than 30); accelerated at 37°C for 30 days, ...

Embodiment 3

[0047] Example 3: Selection of emulsifier and co-emulsifier, and selection of oil-phase co-dispersant.

[0048] The phospholipids described in Example 3 below are concentrated phospholipids with an acetone-intolerant content of more than 50%, including concentrated sunflower phospholipids and concentrated soybean phospholipids.

[0049] (1) Mix 250 g of octenyl succinic acid mono-arabic gum ester, 100 g of erythritol, 5 g of sucrose fatty acid ester and 500 g of water and stir well, add 120 g of astaxanthin, 20 g of mixed tocopherol, 0.1 g of potassium sorbate, After stirring evenly, shear pre-emulsification at 10,000 rpm for 1min, and homogenize at 45Mpa to obtain astaxanthin emulsion with a particle size of 1.2 microns; its ZETA potential is -25mV (when the absolute value is greater than 30, the system is considered to be stable); 37 ℃ accelerated 30 Days, the content retention rate is 81%, the particle size is 1.9 microns, the preparation time is 32s, there is a trace amoun...

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Abstract

The invention discloses an astaxanthin nano-emulsion with good blending properties. The astaxanthin nano-emulsion is a nanoscale emulsion product produced by the following ingredients in parts by weight: 10-15 parts of astaxanthin, 10-30 parts of embedded wall materials, 8-25 parts of filling materials, 0.1-3 parts of main emulsifiers, 0.01-0.2 part of co-emulsifier, 0.01-0.1 part of oil phase co-dispersant, 45-55 parts of dilution media, 0-5 parts of antioxidants and 0-0.5 part of bacteriostatic agent. According to the astaxanthin nano-emulsion, through a microencapsulation technology, the inherent defects of fat-soluble astaxanthin raw materials in application can be overcome, and the problems of low bioavailability, poor water solubility, complex technologies, difficulty in industrialization, unclear application characteristics and the like are solved. Through the combined utilization of the wall materials, the filling materials and the emulsifiers, the blending properties of the astaxanthin emulsion can be greatly improved. On the basis, the astaxanthin emulsion can be taken as a raw material to be widely applied to various liquid foods and functional foods, including beverages, milk products, oral liquids and the like.

Description

technical field [0001] The invention belongs to the technical field of preparation of functional additives, and in particular relates to a nano-scale astaxanthin emulsion with good reconstitution property and a preparation method. Background technique [0002] Carotenoids are natural active ingredients with physiological functions such as scavenging free radicals, quenching singlet oxygen, and preventing cardiovascular diseases. [0003] Astaxanthin is composed of 4 isoprene double bonds connected end to end, a total of 11 conjugated double bonds, the molecular formula is C 40 H 52 O 4 , with a relative molecular weight of 596.86, is a keto carotenoid. Astaxanthin is fat-soluble, insoluble in water, and has strong pigmentation ability. As a functional pigment, it can be used as a colorant. At the same time, astaxanthin has strong antioxidant function and anti-photosensitivity effect. As the substance with the strongest antioxidant ability from natural sources, it has uni...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L2/52A23L33/00A23C9/152A61K31/122A61K9/107A61K47/36A61K47/14A61K47/26A61K47/24A61P39/06A61P25/28A61P35/00
CPCA23L2/52A23L33/00A23C9/152A23C9/1528A61K31/122A61K9/1075A61K47/36A61K47/14A61K47/26A61K47/24A61P39/06A61P25/28A61P35/00A23V2002/00A23V2200/30A23V2250/2104A23V2200/222A23V2200/02A23V2250/5114A23V2250/6402A23V2250/6422A23V2250/61A23V2250/28A23V2250/628A23V2250/642A23V2250/186A23V2250/1944A23V2250/708A23V2250/1614A23V2250/054A23V2250/16
Inventor 李倩陈剑彬马宇骥吴文忠
Owner INNOBIO CORP LTD
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