Tricyclic diterpene-2-methylpyrimidine analogues, preparation method and application thereof

Abstract

The invention discloses tricyclic diterpene-2-methylpyrimidine analogues represented by formulas (X) and (I)-(IV), and a preparation method thereof, wherein a target product is prepared through IBX oxidation, Aldol condensation, substitution, cyclization, haloform reaction, hydrolysis, condensation and other reactions. The invention also provides an application of the tricyclic diterpene-2-methylpyrimidine analogue in resisting late onset hypogonadism (LOH). The invention also relates to a new mechanism, namely an autophagy mechanism, of the tricyclic diterpene-2-methylpyrimidine analogue in LOH treatment so as to provide a beneficial reference for research in resisting late onset hypogonadism, wherein the good application prospect is achieved.

Description

technical field

[0001] The invention belongs to the technical field of medicine and its preparation and application, and in particular relates to a tricyclic diterpene 2-methylpyrimidine analogue and its preparation method and application. Background technique

[0002] Late-onset hypogonadism (LOH) is an age-related clinical syndrome in which testosterone levels decline in patients, causing a series of conditions that lead to reduced quality of life, such as decreased libido, fatigue, depressed mood, and erectile dysfunction And so on, it will cause multiple organ dysfunction at the same time. The incidence of LOH in men gradually increased with age. With the intensification of global aging, various aging-related diseases have attracted increasing attention, and LOH has also become a research hotspot in recent years. A recent epidemiological survey conducted in a community in my country found that about 9.1% of middle-aged and elderly men had low serum testosterone levels ...

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