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Thifluzamide-loaded folic acid/zinc nitrate gel system as well as preparation method and application thereof

A technology of thifuramide and zinc nitrate, which is applied in the field of pesticide formulations, can solve the problems of small spray droplet size and drift loss, and achieve the effects of inhibiting splitting, increasing leaf deposition, and reducing environmental pollution

Active Publication Date: 2020-07-17
INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the addition of adjuvants to some extent leads to a smaller spray droplet size, resulting in drift losses during the spraying process

Method used

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  • Thifluzamide-loaded folic acid/zinc nitrate gel system as well as preparation method and application thereof
  • Thifluzamide-loaded folic acid/zinc nitrate gel system as well as preparation method and application thereof
  • Thifluzamide-loaded folic acid/zinc nitrate gel system as well as preparation method and application thereof

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preparation example Construction

[0026] The present invention also provides a preparation method of the gel system, comprising the following steps: (1) after mixing folic acid with water, dissolving in an alkaline environment to obtain a folic acid neutralizing solution;

[0027] (2) After mixing Thiofuramide and absolute ethanol according to the mass volume ratio of 0.5g: 10mL, obtain Thiofuramide ethanol solution;

[0028] (3) Mix and vortex the folic acid neutralization solution described in step (1), the ethanol solution of thiafluxamide and the zinc nitrate solution described in step (2), and obtain the gel system after standing;

[0029] There is no temporal sequence between step (1) and step (2).

[0030] In the invention, the folic acid is mixed with water and dissolved in an alkaline environment to obtain a folic acid neutralizing solution. The ratio of folic acid and water in the present invention is preferably 66.2mg: 10mL. The water described in the present invention is preferably ultrapure wate...

Embodiment 1

[0044] Preparation of Folic Acid / Zinc Nitrate Gel Loaded with Thioflurane

[0045] 1. Weigh 66.2 mg of folic acid into a small beaker filled with 10 mL of ultrapure water. The pH of the folic acid solution was then adjusted to about 11 using KOH solution until a clear neutralized solution was obtained.

[0046] 2. Dissolve 0.5 g of thifluzamide technical substance (purity: 96%) in 10 mL of absolute ethanol.

[0047] 3. Prepare 100 mM zinc nitrate solution.

[0048] 4. Use a pipette gun to pipette the folic acid neutralization solution, thifuramide ethanol solution and zinc nitrate solution into a 5mL plastic test tube according to the ratio requirements of the components of the final gel system. After vortexing for 30 seconds to 1 minute, the test tube was allowed to stand for 30 min to obtain thifluzamide gel (loaded thifluzamide folic acid / zinc nitrate gel), and the concentration of folic acid in the gel system was 15mM, the mass concentration is 6.62mg / mL, and the molar ...

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Abstract

The invention provides a thifluzamide-loaded folic acid / zinc nitrate gel system as well as a preparation method and application thereof, and relates to the technical field of pesticide formulations. The maximum loading capacity of thifluzamide in the gel system disclosed by the invention is 5 mg / mL; the concentration of folic acid in the gel system is 15 mM; the molar ratio of folic acid to zinc ions in the gel system is 1:(1.8-2.3). The gel system has the advantages that the raw materials are easy to obtain, non-toxic and biodegradable, environmental pollution can be reduced by using the thifluzamide-loaded folic acid / zinc nitrate gel, splitting, splashing and bouncing of liquid drops can be remarkably inhibited, and foliage deposition is increased. Meanwhile, the thifluzamide-loaded folic acid / zinc nitrate hydrogel system has the biological activity of banded sclerotial blight resistance, and possibly has important significance for researching a new pesticide formula.

Description

technical field [0001] The invention belongs to the technical field of pesticide formulations, and in particular relates to a folic acid / zinc nitrate gel system loaded with thifluxamide and its preparation method and application. Background technique [0002] Spraying pesticides is a common method for controlling pests and weeds. The ultimate goal of spraying is to obtain sufficient coverage and uniform pesticide deposition on the leaves of target crops to achieve a good control effect. However, due to factors such as weather, spray solution, target plant biological characteristics, and spray equipment, the pesticide droplet drifts and the droplet bounces from the target plant leaves, and the actual utilization rate of the pesticide is low. Pesticide droplets bounce and roll off the leaves of target plants, causing pollution to soil, water sources and non-target organisms. In order to inhibit the bouncing behavior of pesticide droplets on the target plant leaves, the depos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N47/02A01N25/10A01P3/00
CPCA01N25/10A01N47/02
Inventor 曹冲黄啟良宋玉莹郑丽曹立冬李凤敏赵鹏跃
Owner INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI