Antifungal application of metal organic framework material

A metal-organic framework and anti-fungal technology, applied in non-medical fields, can solve problems such as ultraviolet radiation, high temperature, and fungi that are not easy to be killed

Pending Publication Date: 2020-07-24
理工清科(北京)科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Moreover, fungi are not easy to be killed. The commonly used antifungal methods such as high temperature and ultraviolet light not only require special equipment, but also have dangers such as ultraviolet radiation and high temperature.

Method used

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  • Antifungal application of metal organic framework material
  • Antifungal application of metal organic framework material
  • Antifungal application of metal organic framework material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Such as figure 1 As shown, 2 mL of Candida albicans (ATCC 10231) suspension (original concentration C 0 =10 5 CFU mL –1) dropwise and uniformly drop-coated on the substrate 2 loaded with metal-organic framework 1 (non-woven fabric was used in this experiment, other available substrates can be silk cloth, glass fiber, metal mesh, metal foam, polyurethane sponge, melamine sponge, etc.), the substrate 2 is soaked in sterile distilled water 3. After 1 hour, use 20 mL of 0.9% (w / v) normal saline solution to elute the above metal-organic framework-loaded substrate, and then use the 2-fold dilution method to serially dilute the eluate, and then take Diluted samples (50 μL) were placed on nutrient agar medium. These plates were incubated at 37°C for 20 hours and viable cell counts were performed to obtain the post-bacterial concentration (C). In the present invention, the antibacterial effect is expressed as (C 0 -C) / C. In the above case, a blank control experiment was c...

Embodiment 2

[0035] Except that the metal source of the metal-organic framework is copper nitrate and the organic ligand is trimesic acid, the others are the same as in Example 1. The X-ray diffraction patterns of the prepared metal-organic framework materials are as follows: figure 2 As shown in B, where 3 represents the simulated curve and 4 represents the experimental curve. As shown in the figure, the prepared metal-organic framework coincides with the simulation curve, indicating that the metal-organic framework was successfully obtained.

Embodiment 3

[0037] Except that the metal source of the metal-organic framework is iron nitrate, and the organic ligand is trimesic acid, the others are the same as in Example 1. The X-ray diffraction patterns of the prepared metal-organic framework materials are as follows: figure 2 C, where 5 represents the simulated curve, and 6 represents the experimental curve. As shown in the figure, the prepared metal-organic framework coincides with the simulation curve, indicating that the metal-organic framework was successfully obtained.

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Abstract

The invention relates to the field of non-medicine, and provides a new application of a metal organic framework material. Fungi are contacted with the metal organic framework material to achieve the effect of killing the fungi, and the metal organic framework material is formed by the action of a metal source and an organic ligand. The metal organic framework material is used, so that the antibacterial effect is excellent, and the harm of radiation, high temperature and the like does not exist.

Description

technical field [0001] The invention belongs to the field of non-medicine, and in particular relates to an antifungal application and an antibacterial device using a metal organic framework material. Background technique [0002] Fungi are a class of microorganisms that widely exist in nature and the human body, and some of them are pathogens that cause humans and animals. The current environmental pollution situation is not optimistic. CCTV's "Into Science" column once reported that in smoggy weather, PM2.5 carries a large number of bacteria, fungi and DNA viruses, with a minimum estimate of more than 1,300 species. At the same time, studies have shown that where the most common contact, there are more fungi. Therefore, under the current polluted environment conditions, it is particularly important to kill some harmful fungi in the environment in all human gathering places such as hospitals, schools, units, and families. Moreover, fungi are not easy to be killed. Currentl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N55/02A01N37/10A01P3/00
CPCA01N37/10A01N55/02
Inventor 韩若丹
Owner 理工清科(北京)科技有限公司
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