The invention discloses a preparation method of a
biphenyl compound for synthesizing cephalotaxine, belongs to the technical field of catalytic synthesis, and particularly relates to the preparation method of the
biphenyl compound for synthesizing the cephalotaxine. In order to solve the problems that the existing preparation method for synthesizing the
biphenyl compound of cephalotaxine is expensive in initial raw materials, complex in operation and low in yield of the obtained product, the
biphenyl compound is synthesized by taking commercial reagents homopiperony lamine and
ferulic acid as initial raw materials and taking a Suzuki
coupling reaction as a key step; and the compound can be used as a synthesis precursor of cephalotaxine. According to the
route, commercial reagents are used as raw materials, the reaction cost is reduced, meanwhile, the use conditions are mild, experimental operation is easy, the
biphenyl compound is obtained with the good yield, and meanwhile a certain foundation is laid for synthesis of cephalotaxine. The method is used for synthesizing the
biphenyl compound.