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Anti-oral ulcer preparation and application thereof

A technology for oral ulcers and preparations, which is applied in the field of oral care, can solve the problems of less applied research, and achieve the effect of promoting healing, no irritation or allergic reaction, and alleviating inflammation

Active Publication Date: 2020-08-11
JIANGSU XUE BAO DAILY CHEM CO
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sea octopus polysaccharide 1 is a natural active polysaccharide derived from the marine traditional Chinese medicine sea octopus, which has the functions of anti-oxidation, increasing the levels of epidermal growth factor (EGF) and platelet-derived growth factor (PDGF), and its application research in the field of oral cavity less

Method used

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  • Anti-oral ulcer preparation and application thereof

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Effect test

Embodiment 1

[0017] 1. Preparation of octopus polysaccharide 1

[0018] Weigh a certain amount of squid octopus powder with a particle size of 80-100 mesh, add it to a sodium acetate solution with a pH of 6.5, and make the ratio of solid to liquid 1:30; heat to 55°C, add papain for enzymolysis for 4 hours, and the enzyme dosage is 4 %; after the end of enzymolysis, the temperature was raised rapidly to 90°C, and the enzyme was inactivated for 10 minutes; centrifuged at 8000r / min for 10 minutes, the supernatant was precipitated overnight with ethanol, centrifuged, and the supernatant was freeze-dried to obtain the crude polysaccharide of sea slug; The crude octopus polysaccharide is dissolved in distilled water, separated and purified through an ion exchange gel column and a molecular sieve gel column, and the collected solution is freeze-dried to obtain the octopus polysaccharide-1.

[0019] 2. Preparation of anti-oral ulcer preparations

[0020] First add 80% Aspirin polysaccharide-1, 15...

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Abstract

The invention discloses an anti-oral ulcer preparation. The anti-oral ulcer preparation is characterized by comprising the following components in percentage by mass: 80-90% of cuttlebone polysaccharide 1, 2-20% of lactobionic acid, 0.05-1% of a calcium salt, and 0.5-1% of a plant preservative. The anti-oral ulcer preparation can be used for preparing products such as films, ointments, powders, granules, toothpastes, mouthwashes and oral sprays for treating oral ulcer. In the anti-oral ulcer preparation, the marine organism polysaccharide cuttlebone polysaccharide 1 is used as a main mucous membrane repairing component to relieve the inflammatory response and promoting the healing of ulcer tissues and the repairing of sore surfaces; lactobionic acid and the calcium salt have buffering andsynergistic effects in the repairing process; and the natural plant source preservative is mild and safe, and free of stimulation or allergic reactions.

Description

technical field [0001] The invention belongs to the technical field of oral care, and in particular relates to an anti-oral ulcer preparation capable of alleviating oral ulcer and application thereof. Background technique [0002] Recurrent oral ulceration is one of the most common oral mucosal diseases. Early pathological manifestations include mucosal edema, followed by intraepithelial blisters, gradual dissolution, mucosal ulceration, and necrosis to prevent shedding, forming superficial ulcers. Capillaries in the ulcer were congested and dilated, fibrinous exudate appeared, a large number of inflammatory cells infiltrated, and there was pseudomembrane formation or necrotic tissue in the lesion. The lesion can heal itself in 10-14 days, and generally no scar is formed. [0003] Recurrent oral ulcers have a certain periodicity and are prone to recurrence. At present, the cause of the disease is not clear, and it may be related to many factors such as vitamin and trace ele...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K31/7032A61K33/10A61K31/191A61P1/02
CPCA61K31/191A61K31/7032A61K31/715A61K33/10A61P1/02A61K2300/00
Inventor 李秋雁徐志良张咪
Owner JIANGSU XUE BAO DAILY CHEM CO
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