Efficient synthesis method of weight-reducing component tartronic acid in cucumbers

A technique for the synthesis of tartronic acid, which is applied in chemical instruments and methods, preparation of carboxylate salts, and preparation of organic compounds, etc., can solve the problems that tartronic acid is difficult to meet market demand, and solve the problem of raw material sources , Simple operation, avoiding the effect of high cost of raw materials

Pending Publication Date: 2020-08-11
ANHUI ANLITAI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Due to the limitation of raw materials and extraction process, it is difficult to extract tartronic acid from cucumber to meet the market demand

Method used

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  • Efficient synthesis method of weight-reducing component tartronic acid in cucumbers

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preparation example Construction

[0022] A method for efficiently synthesizing weight loss ingredient propanedioic acid in cucumber, comprising the following steps:

[0023] S1, raw material mixing: add aminomalonic acid and alkenoic acid into the flask for mixing;

[0024] S2, aminomalonic acid carry out diazotization reaction with sodium nitrite in dilute acid;

[0025] S3, after the diazotization reaction is completed, directly heat up and hydrolyze without separation, and then concentrate under reduced pressure to a solid;

[0026] S4, adding alcohol to desalt, recovering alcohol, and obtaining the crude product of tartronic acid;

[0027] S5. The crude product of tartronic acid is dissolved with acid, decolorized by filtration, and the acid is recovered to obtain tartronic acid.

[0028] In said S2, the diazotization reaction temperature is controlled at -5-10°C.

[0029] In S2, the acid used for diazotization is hydrochloric acid or sulfuric acid.

[0030] In said S3, the hydrolysis temperature is co...

Embodiment 1

[0036] In a 500ml three-necked flask, add 60g of aminomalonic acid and 300mL of 2mol / L hydrochloric acid, stir to dissolve and cool down to about 5°C, add 100g of a 40% aqueous solution of sodium nitrite dropwise, and heat it up to 80°C for about 1 hour when no bubbles come out. Make it fully react completely; Concentrate until the colloid is dissolved in anhydrous methanol and filter to remove sodium chloride; Dissolve the crude product in acetic acid, filter, decolorize and recover the acetic acid to obtain colorless crystals, filter to obtain white crystals of 2-hydroxymalonic acid; bake 52g of crystals were obtained, and the yield was 86.7%. Mp160.5°C (decomposition).

Embodiment 2

[0038] In a 500ml three-neck flask, add 60g of aminomalonic acid and 300mL of 2mol / L sulfuric acid, stir to dissolve and cool down to about 5°C, add 100g of a 40% aqueous solution of sodium nitrite dropwise, and heat it up to 80°C for about 1 hour when no bubbles come out. Make it fully react completely; Concentrate until the colloid is dissolved in anhydrous methanol and filter to remove sodium chloride; Dissolve the crude product in acetic acid, filter, decolorize and recover the acetic acid to obtain colorless crystals, filter to obtain white crystals of 2-hydroxymalonic acid; bake 55g of crystals were obtained, and the yield was 91.7%. Mp160.0°C (decomposition).

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Abstract

The invention provides an efficient synthesis method of weight-reducing component tartronic acid in cucumbers, which comprises the following steps: S1, preparing tartronic acid: carrying out diazotization reaction on aminomalonic acid serving as a raw material to obtain tartronic acid; S2, carrying out diazotization reaction on aminomalonic acid and sodium nitrite in a dilute acid; S3, after diazotization reaction is finished, directly heating and hydrolyzing without separation, and then concentrating under reduced pressure to obtain a solid; S4, adding an alcohol to remove salt, and recovering the alcohol to obtain a tartronic acid crude product; and S5, dissolving the tartronic acid crude product with an acid, filtering, decolorizing, and recovering the acid to obtain tartronic acid . The method has the advantages that aminomalonic acid with wide sources is used as the raw material, and the tartronic acid is obtained in one step through diazotization reaction, so that the problem ofraw material sources is solved, and the defects of high raw material cost, complex product, difficulty in separation and purification and the like are overcome; the method has the advantages of easily available raw materials, high raw material conversion rate, high purity and yield, stable process conditions and simple operation.

Description

technical field [0001] The invention relates to the technical field of processing methods of tartronic acid, in particular to a high-efficiency synthesis method of tartronic acid, a weight-loss ingredient in cucumber. Background technique [0002] Due to lack of exercise, irregular diet, and unbalanced nutrition, more and more people are overweight. According to statistics, there are currently about 2 billion people in the world who are overweight or obese. Weight loss has become a global topic. The main ways to lose weight are: exercise to lose weight, diet to lose weight, medicine to lose weight, traditional Chinese medicine to lose weight, surgery to lose weight, catering to lose weight and meal replacement to lose weight. [0003] Malonic acid is a small molecular organic acid, also known as hydroxymalonic acid. It can inhibit the conversion of carbohydrates into fat in the human body, prevent the accumulation of fat in the body, and has the effect of losing weight and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/367C07C59/245
CPCC07C51/367C07C245/20C07C59/245
Inventor 马铭泽马云峰丁洋
Owner ANHUI ANLITAI BIOTECH CO LTD
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