Biodegradation novel medical composition of novel cisplatin nanometer and preparation method of biodegradation novel medical composition

Abstract

The invention provides a biodegradation novel medical composition of novel cisplatin nanometer and a preparation method of the biodegradation novel medical composition, and relates to the technical field of medical treatment. The biodegradation novel medical composition of novel cisplatin nanometer consists of components in parts by weight of 15-25 parts of a cisplatin compound, 40-50 parts of a carrier material, 30-40 parts of adriamycin, 120-200 parts of a block copolymer, 1-2 parts of mannitol, 1-3 parts of lentinan and 2-4 parts of vitamin C. Through the prepared cisplatin compound, a cisplatin aqueous solution is stable in properties, and is not liable to be subjected to grade-by-grade hydration and hydrolytic reaction in water; and consumption of the cisplatin is reduced, so that side effect on organs of human bodies can be further reduced to a certain extent, the toxin expression of the cisplatin aqueous solution is obviously reduced, and patients are not liable to generate unhealthy tendency.

Description

technical field [0001] The invention relates to the technical field of medical treatment, in particular to a novel cisplatin nanometer biodegradable pharmaceutical composition and a preparation method. Background technique [0002] Cisplatin is a heavy metal complex in which divalent platinum is combined with two chlorine atoms and two ammonia molecules. It is similar to a bifunctional alkylating agent and can inhibit the DNA replication process. DDP cells are the most sensitive and inhibit RNA and protein synthesis at high concentrations. This product acts on hypoxic cells and can diffuse through the charged cell membrane after entering the human body. At present, it is believed that DDP mainly acts on the purine and pyrimidine bases of DNA. Action and use: This product is a non-specific drug for the cell cycle, has cytotoxicity, can inhibit the DNA replication process of cancer cells, and damage the structure on the cell membrane, and has a strong broad-spectrum anti-can...

AI Technical Summary

Problems solved by technology

[0003] At present, when a large dose (80-120mg / m2) of cisplatin is used, hydration and diuresis must be carried out at the same time. The so-called hydration therapy is hydration, diuresis and increasing the amount of chlorine in urine to reduce kidney toxicity. The treatment method is generally to dissolve 1000ml of normal saline or glucose before administering large doses of DDP, add chlorine and then instill, and DDP is diluted with 200ml of normal saline before dripping. Gradual hydration and hydrolysis reactions occur, and although the existing cisplatin aqueous solution has reduced side effects on human organs to a certain extent, the toxicity of cisplatin aqueous solution is still obvious, and patients are prone to various adverse phenomena