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Application of gsdmd inhibitor in preparation of medicine for treating helicobacter pylori infection

A Helicobacter pylori and inhibitor technology, applied in the application field of drugs, can solve the problems of changes in the molecular mechanism of pyroptosis, unclear neutrophil death signaling pathways, etc., and achieve the goal of reducing inflammatory response and reducing drug resistance. Effect

Active Publication Date: 2021-04-23
威海市立医院 +1
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Problems solved by technology

[0004] The present invention provides the application of GSDMD inhibitor in the preparation of medicine for treating Helicobacter pylori infection, especially the application of GSDMD inhibitor in the preparation of neutrophil infiltration target medicine of Helicobacter pylori infection, aiming to solve the unclear The death signaling pathway of neutrophils after Helicobacter pylori infection, especially the change of the molecular mechanism of pyroptosis; after clarifying the signaling pathway, it is suggested that GSDMD inhibitor (necrosulfonamide) can be used to treat Helicobacter pylori infection in the stomach and inhibit the infection site The pyroptotic process of infiltrating neutrophils can replace the combination therapy of antibacterial drugs currently used in clinical practice, reduce the generation of drug resistance, and solve the problems existing in the prior art

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  • Application of gsdmd inhibitor in preparation of medicine for treating helicobacter pylori infection

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Embodiment Construction

[0031] In order to clearly illustrate the technical features of this solution, the present invention will be described in detail below through specific implementation modes.

[0032] The embodiment of the present invention provides the application of GSDMD inhibitor (necrosulfonamide) as a drug in the treatment of neutrophil infiltration of gastric Helicobacter pylori infection, the application adopts GSDMD inhibitor (necrosulfonamide) to inhibit the neutrophils infected by gastric Helicobacter pylori Pyroptosis, by inhibiting the pyroptosis process of neutrophils, reducing the infiltration of neutrophils, reducing the inflammatory response, prolonging the survival time of neutrophils that are no longer pyroptotic, and exerting better phagocytosis, playing a very good role Therapeutic effect, replacing the clinically used antimicrobial drug combination therapy in the treatment of gastric Helicobacter pylori infection, greatly reducing the occurrence of drug resistance.

[0033...

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Abstract

The invention relates to the technical field of biomedicine, in particular to the application of GSDMD inhibitors in the preparation of medicines for treating Helicobacter pylori infection. It aims to solve the problem that the death signaling pathway of neutrophils after Helicobacter pylori infection is unclear in the prior art, especially the change of the molecular mechanism of pyroptosis; after clarifying the signaling pathway, it suggests that GSDMD inhibitors can be used to treat Helicobacter pylori in the stomach Infection, inhibiting the pyroptotic process of neutrophils infiltrating the infection site, to replace the clinically used antibacterial drug combination therapy, and reduce the emergence of drug resistance.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of GSDMD inhibitors in the preparation of medicines for treating Helicobacter pylori infection. Background technique [0002] Helicobacter pylori (H. pylori) is a class I carcinogen, and infection with H. pylori can cause various diseases such as gastroduodenal inflammation. For some patients, the efficacy of H.pylori clinical drug eradication is not satisfactory. Neutrophils are an important component of the body's innate immune system and play an important role in the body's defense against the invasion of pathogenic microorganisms. Studying the mechanism of H.pylori-induced neutrophil death disorder can reveal the role of neutrophils in the body's anti-infection immunity, which is of great significance for the prevention and treatment of related diseases caused by H.pylori. [0003] Pyroptosis is a kind of cell lytic death that relies on inflammatory casp...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/00A61K31/505A61P31/04A61P1/04A61P35/00C12Q1/02G01N33/68
CPCA61K31/505A61K45/00A61P1/04A61P31/04A61P35/00G01N33/5005G01N33/68
Inventor 王明义刘鹏
Owner 威海市立医院
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