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Compound quercetin antibacterial nanoemulsion and preparation method thereof

A quercetin and nanoemulsion technology, applied in the field of medicine, can solve the problems of unclear antibacterial compatibility mechanism, poor water solubility of quercetin, low bioavailability, etc., and achieves good solubilization effect, good antibacterial effect, and simple preparation method. Effect

Inactive Publication Date: 2020-08-18
INNER MONGOLIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Quercetin, the main component of Chinese monarch medicine Wenguanmu, has poor water solubility and low bioavailability; and the antibacterial compatibility mechanism of each component is unknown

Method used

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  • Compound quercetin antibacterial nanoemulsion and preparation method thereof
  • Compound quercetin antibacterial nanoemulsion and preparation method thereof
  • Compound quercetin antibacterial nanoemulsion and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0036] A compound quercetin antibacterial nanoemulsion, the particle size of the nanoemulsion is between 1 and 100nm, and is composed of the following raw materials in mass percentage: Tween-80 25.0%, ethyl acetate 4.4%, absolute ethanol 12.5%, 0.2016% of quercetin, 0.0476% of tannin, 0.8064% of toosendanin, the rest is distilled water, and the sum of the mass percentages of the above raw materials is 100%.

[0037] The preparation method of above-mentioned compound quercetin antibacterial nanoemulsion, comprises the following steps:

[0038] Step 1, weigh Tween-80, ethyl acetate, absolute ethanol, quercetin, tannin, toosendanin and distilled water according to the formula ratio, and set aside;

[0039] Step 2, dissolving the quercetin and toosendanin in ethyl acetate, and heating it to 40-60°C to fully dissolve it as an oil phase;

[0040] Step 3, adding the Tween-80 into the oil phase, stirring at 800rpm / min for 30 minutes and mixing;

[0041] Step 4, adding the absolute e...

Embodiment 2

[0045] A compound quercetin antibacterial nanoemulsion drug, the quality of each component: RH-40 27%, isopropyl myristate 3.3%, absolute ethanol 1%, quercetin 0.2%, tannin 0.0486%, gardenia glycoside 0.18%, toosendanin 0.8%, and the balance is distilled water.

Embodiment 3

[0047] A compound quercetin antibacterial nanoemulsion drug, the quality of each component: EL-40 36%, absolute ethanol 12%, ethyl acetate 4%, quercetin 0.2%, tannin 0.0475%, geniposide 0.18 %, toosendanin 0.8224%, and the balance is distilled water.

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Abstract

The invention belongs to the field of medicines, and relates to a compound quercetin antibacterial nanoemulsion medicine and a preparation method thereof. The compound quercetin antibacterial nanoemulsion is prepared from the following raw materials in percentage by mass: 10-30% of starch and the balance of water. The invention relates to an anti-dandruff shampoo, which is prepared from the following components in percentage by weight: 24.00 to 40.00 percent of surfactant, 0 to 20 percent of cosurfactant, 3.00 to 23.5 percent of oil, 0.1976 to 0.2056 percent of quercetin, 0.0466 to 0.0486 percent of tannin and 0.7904 to 0.8224 percent of toosendanin, wherein the sum of the mass percentages of the raw materials is 100%. The Mongolian medicine compound quercetin nanoemulsion prepared by thepreparation method disclosed by the invention has a good antibacterial effect and good thermodynamic stability.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new dosage form of antibacterial drugs, in particular to a compound quercetin antibacterial nanoemulsion drug and a preparation method thereof. Background technique [0002] Mongolian medicine Senden-4 is an antirheumatic drug commonly used in Mongolian medicine. It has the effects of clearing away heat and dampness, anti-inflammatory and analgesic, and is used to treat arthritis, edema and other diseases. In recent years, studies have found that the Mongolian medicine Sendeng-4 also has certain effects on the treatment of tinea manus and pedis. The three active ingredients used as the quality control index of Senden-4 all have a certain inhibitory effect on bacteria such as Escherichia coli and Staphylococcus aureus. [0003] At present, senden-4 mainly includes decoction and capsule in the market, and its nanoemulsion has not been reported. Quercetin, the main component of Sendeng-4, h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K47/14A61K47/26A61K47/44A61K31/352A61K31/58A61K31/7024A61P31/04
CPCA61K9/0014A61K9/1075A61K31/352A61K31/58A61K31/7024A61K47/14A61K47/26A61K47/44A61P31/04A61K2300/00
Inventor 武世奎张燕芳都日娜高耀星赵鹏伟卢莎乌日娜布仁
Owner INNER MONGOLIA MEDICAL UNIV
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