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Composite material forming glucometer docking station, preparation method and application thereof

A composite material and blood glucose meter technology, applied in analytical materials, material testing products, instruments, etc., can solve the problems of error, high cost, and high operation requirements of immunological detection methods, and achieve shortened detection time, specific detection function, and improved sensitivity. Effect

Pending Publication Date: 2020-08-21
重庆宏道拓土科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In order to solve the above-mentioned problems that there are errors in different degrees and directions in the detection of tumor markers, which cannot accurately reflect the actual situation, hinder doctors from judging the development of the disease, and the existing clinical immunological detection methods have high operational requirements and high costs. The present invention Provide a composite material constituting the "docking station" of a blood glucose meter, its preparation method and application

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  • Composite material forming glucometer docking station, preparation method and application thereof
  • Composite material forming glucometer docking station, preparation method and application thereof
  • Composite material forming glucometer docking station, preparation method and application thereof

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Embodiment 1

[0039] The preparation method of the composite material constituting the "docking station" of the blood glucose meter, the preparation of the composite material constituting the "docking station" of the blood glucose meter, the method comprises the following steps:

[0040] S1: Preparation of Mesoporous Silica Nanoparticles

[0041] Weigh 0.15g of cetyltrimethylammonium bromide (CTAB) and 0.04g of tetrahydroxyethylethylenediamine (THEEDA) and dissolve them in 10mL of ultrapure water, heat in an oil bath, and stir at 60°C for 30min , quickly added 1.5ml tetraethylorthosilicate (TEOS) to the reaction system, and kept stirring for 3 hours. After the reaction was completed and centrifuged, the precipitate was ultrasonically dispersed in 15 ml of acid-alcohol solution for 30 minutes to remove the template agent, and finally collected by centrifugation and dried in vacuum at 60° C. overnight to obtain mesoporous silica nanoparticles. The appearance of the prepared mesoporous silica...

Embodiment 2

[0048] This embodiment provides an application of the "docking station" composite material of the blood glucose meter, which is a blood glucose meter-docking station platform based on the "docking station" composite material of the tumor marker Her-2, which is used for the Detection, the platform includes a household personal blood glucose meter and the "docking station" composite material prepared above, the specific scheme of the detection method is as follows:

[0049] Blood glucose meter-"docking station" composite material to detect Her-2 antigen standard sample

[0050] The specific operation is: weigh two equal parts of the composite material of the blood glucose meter "docking station" prepared above, wash with PBS buffer, and centrifuge until the supernatant is detected by the blood glucose meter to be zero, and then dissolved in PBS buffer Among them, DNA aptamer standard samples were added to one of them, and the other was left untreated; after two hours of incubati...

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Abstract

The invention belongs to the technical field of crossing of a drug delivery system and biosensing technology, and particularly relates to a composite material forming a glucometer docking station, a preparation method and application thereof. The composite material forming the glucometer docking station comprises mesoporous silica nanoparticles with surfaces modified by a DNA aptamer and glucose,according to the mesoporous silica nanoparticles with surfaces modified by a DNA aptamer, carboxylated mesoporous silica nanoparticles are connected to the DNA aptamer through an amido bond to construct DNA gating so as to close or open pore channels of the mesoporous silica nanoparticles; and the glucose is located in the pore channel structure of the mesoporous silica nanoparticle with the surfaces modified by the DNA aptamer, and after the DNA is gated to recognize protein, the DNA-protein compound changes the conformation of the DNA and opens the pore channels of the mesoporous silica to release the glucose, so that detection of a tumor marker is realized.

Description

technical field [0001] The invention belongs to the cross-technical field of drug delivery system and biosensing technology, and specifically relates to a blood glucose meter "docking station" made of composite materials and a method for converting tumor marker-glucose signals. Background technique [0002] Tumor markers are the only way to detect asymptomatic microfocal tumors early, and to detect them for tumor screening and timely diagnosis. In prognosis rehabilitation management and recurrence early warning, the prognosis effect is judged by timely detection of tumor markers. Therefore, the detection of tumor markers also plays an important role in prognosis rehabilitation management and recurrence early warning. In the detection of tumor markers, through close detection of tumor markers, their dynamic numerical fluctuations can be used as an index to evaluate the curative effect, so as to guide the individual course of treatment for patients. In advanced patients, the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/66G01N33/574
CPCG01N33/66G01N33/57415
Inventor 杨胜斐杨欣馨彭倩瑜唐瑞璐
Owner 重庆宏道拓土科技有限公司