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Florfenicol soluble powder medicine

A florfenicol, soluble technology, applied in the field of Chuju, can solve the problems of unfavorable promotion and application, inconvenient administration, low absorption and bioavailability, etc., and achieves the effect of enhancing the therapeutic effect and overcoming the low water solubility.

Inactive Publication Date: 2020-08-25
江西派尼生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Florfenicol has low solubility and is a water-insoluble powder, which affects the development of its soluble powder to a certain extent. Its absorption and bioavailability in animals are low, and it is often administered by mixing it into feed. The route of administration is single, which limits the full play of the drug effect. Due to the inconvenient administration, the appetite is lost when the poultry and livestock get sick, often resulting in poor curative effect, which is also unfavorable for its popularization and application in breeding production.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A florfenicol soluble powder pharmaceutical formula, the raw materials are as follows in parts by mass: 10 parts of florfenicol, 10 parts of tilmicosin, 30 parts of anhydrous citric acid, 35 parts of colistin sulfate, 10 parts of dried tangerine peel 10 parts of hawthorn, 25 parts of green peel, 2 parts of co-solvent, 0.8 part of thickener, 0.5 part of stabilizer and 10 parts of anhydrous glucose, the co-solvent is a paste, and the co-solvent is in the form of a paste. The throwing ratio of the test is 1:5, the thickener is the mixture of aluminum magnesium silicate, sodium alginate, polyacrylic acid and xanthan gum, and the mixing ratio is 1:1:1:1, and the stabilizer is The mixture of hydroquinone and pH buffer solution, the mixing ratio is 1:2, and the pH value of the pH buffer solution is between 1.68-1.72.

[0025] The present invention also provides a preparation method of a florfenicol soluble powder pharmaceutical formulation, comprising the following steps:

[...

Embodiment 2

[0036] Different from embodiment 1, a kind of florfenicol soluble powder powder pharmaceutical formula, its raw materials are as follows in parts by mass: 15 parts of florfenicol, 15 parts of tilmicosin, 35 parts of anhydrous citric acid, sulfuric acid 40 parts of colistin, 15 parts of dried tangerine peel, 15 parts of hawthorn, 30 parts of green peel, 2.5 parts of co-solvent, 0.9 part of thickener, 0.6 part of stabilizer and 15 parts of anhydrous glucose, the co-solvent is a paste, the The throwing ratio of the cosolvent and the florfenicol is 1:5, the thickener is a mixture of aluminum magnesium silicate, sodium alginate, polyacrylic acid and xanthan gum, and the mixing ratio is 1:1:1 : 1, the stabilizer is the mixture of hydroquinone and pH buffer, the mixing ratio is 1:2, and the pH value of the pH buffer is between 1.68-1.72.

Embodiment 3

[0038] Different from embodiment 1, a kind of florfenicol soluble powder powder pharmaceutical formulation, its raw materials are as follows in parts by mass: 20 parts of florfenicol, 20 parts of tilmicosin, 40 parts of anhydrous citric acid, sulfuric acid 45 parts of colistin, 20 parts of dried tangerine peel, 18 parts of hawthorn, 35 parts of green peel, 3 parts of co-solvent, 1.0 part of thickener, 0.7 part of stabilizer and 20 parts of anhydrous glucose, the co-solvent is a paste, the The throwing ratio of the cosolvent and the florfenicol is 1:5, the thickener is a mixture of aluminum magnesium silicate, sodium alginate, polyacrylic acid and xanthan gum, and the mixing ratio is 1:1:1 : 1, the stabilizer is the mixture of hydroquinone and pH buffer, the mixing ratio is 1:2, and the pH value of the pH buffer is between 1.68-1.72.

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Abstract

The invention discloses a florfenicol soluble powder medicine. The medicine is prepared from the following raw materials in parts by mass: florfenicol, tilmicosin, anhydrous citric acid, colistin sulfate, pericarpium citri reticulatae, fructus crataegi, pericarpium citri reticulatae viride, a cosolvent, a thickener, a stabilizer and anhydrous dextrose, the cosolvent is paste, and the adding ratioof the cosolvent to florfenicol is 1:5. The florfenicol soluble powder medicine and the preparation method thereof are strictly controlled, and the florfenicol and the synergist are combined for use,so that the treatment effect of the whole powder is enhanced. Meanwhile, in the specific preparation process, the florfenicol and the anhydrous citric acid are reasonably proportioned and ground and crushed, so that the defect of low water solubility of the florfenicol is overcome, and the florfenicol can be completely blended into water; and meanwhile, the pericarpium citri reticulatae, the fructus crataegi and the pericarpium citri reticulatae viride are added into the raw materials, so that the effects of appetizing and spleen refreshing of the medicine can be improved, and gastrointestinalmotility is promoted by soothing liver, benefiting gallbladder, harmonizing stomach and thickening intestines.

Description

technical field [0001] The invention relates to the technical field of Chuju, in particular to a florfenicol soluble powder medicine. Background technique [0002] Veterinary drugs have a long history in my country's traditional veterinary culture, and are valuable experience summed up by Chinese veterinarians in the continuous practice of research and treatment of livestock and poultry diseases. Gastrointestinal motility is an important part of the physiological function of the digestive tract, and its dysfunction is one of the important factors causing digestive tract symptoms. In recent years, people have made more explorations on the effects of pharmaceuticals on gastrointestinal motility and its regulatory mechanism, and developed some traditional Chinese medicines to enhance gastrointestinal motility, promote emptying, and promote growth in pigs. As a veterinary-specific third-generation fluoromycin broad-spectrum antibacterial drug, florfenicol is mainly used for the...

Claims

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Application Information

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IPC IPC(8): A61K38/12A61K36/752A61K47/26A61K47/12A61P1/14A61P31/04A61K9/14A61K31/165A61K31/706A61K36/734
CPCA61K31/165A61K31/706A61K38/12A61K36/752A61K36/734A61K9/145A61P31/04A61P1/14A61K2300/00
Inventor 易彦洋曾繁山
Owner 江西派尼生物药业有限公司