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Pharmaceutical composition and application thereof in preparation of products for treating prostatitis

A prostatitis and composition technology, applied in the field of biotechnology and pharmaceutical preparation, can solve the problems that the prostatitis field involves less, lycopene, quercetin and curcumin combined drug research has not been reported in literature, etc. Effect, effect of reducing dosage, reducing production cost

Inactive Publication Date: 2020-08-28
CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Lycopene, quercetin and curcumin are found in the basic research of a variety of inflammatory diseases, such as hepatitis, pancreatitis, uveitis, ischemia-reperfusion injury, etc., but they are rarely involved in the treatment of prostatitis, and lycopene There is no literature report on the research on the combined use of quercetin, quercetin and curcumin

Method used

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  • Pharmaceutical composition and application thereof in preparation of products for treating prostatitis
  • Pharmaceutical composition and application thereof in preparation of products for treating prostatitis
  • Pharmaceutical composition and application thereof in preparation of products for treating prostatitis

Examples

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Embodiment 1

[0059] Embodiment 1, the pharmaceutical composition that lycopene, quercetin and curcumin form and preparation thereof

[0060] The pharmaceutical composition is made of the following components in parts by mass:

[0061] 1 part lycopene;

[0062]1 part quercetin;

[0063] Curcumin 1 part.

[0064] A medicine is prepared from the above-mentioned pharmaceutical composition as an active ingredient, and the dosage form is an oral preparation, which is a suspension.

[0065] The preparation method of the above drug suspension comprises the following steps: 1) the lycopene suspension is prepared by dissolving lycopene in corn oil, and the concentration is 10 mg / ml;

[0066] The quercetin suspension is prepared by dissolving quercetin in 25% hydroxypropyl-β-cyclodextrin mother liquor with a concentration of 10 mg / ml;

[0067] The curcumin suspension is prepared by dissolving curcumin in 25% hydroxypropyl-β-cyclodextrin mother liquor with a concentration of 10 mg / ml;

[0068] Th...

Embodiment 2

[0070] Embodiment 2, lycopene, quercetin and curcumin are used in combination to treat prostatitis animal model

[0071] 1. Construction of rat chronic nonbacterial prostatitis model ("Replication of Rat Nonbacterial Prostatitis Model", Yang Xiaorong et al., Experimental and Laboratory Medicine)

[0072] 1) Experimental animals: 30 male SD rats aged 6-8 weeks, weighing 260-280 g, were fed for 1 week before the experiment.

[0073] 2) Grouping of animals: randomly divided into normal group, model group, lycopene treatment group, quercetin treatment group, curcumin treatment group and combined drug group (i.e. lycopene, quercetin and curcumin combined drug group, It is the medicine prepared in Example 1 of the present invention), 6 in each group.

[0074] 3) Construct rat chronic non-bacterial prostatitis model: model group and 4 treatment groups (namely lycopene treatment group, quercetin treatment group, curcumin treatment group and combination drug group) rats, with 6% hydra...

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Abstract

The invention discloses a pharmaceutical composition and application thereof in preparation of products for treating prostatitis. The pharmaceutical composition is prepared from the following components in parts by mass: 1 part of lycopene, 0.5-2 parts of quercetin and 0.5-2 parts of curcumin. An active component of a drug is the pharmaceutical composition. The pharmaceutical composition or the drug is applied to the products for treating animal and / or human prostatitis. By virtue of combined application of the lycopene, the quercetin and the curcumin in the pharmaceutical composition, a synergistic effect can be generated, so that an action effect on the treatment of the prostatitis is improved; by virtue of the combined application of the lycopene, the quercetin and the curcumin in the pharmaceutical composition, the use amount of the lycopene can be reduced, so that the production cost caused by the price of the lycopene is lowered; and by virtue of the combined application of the lycopene, the quercetin and the curcumin, a foundation is provided for clinical development of drugs for treating chronic prostatitis.

Description

technical field [0001] The invention relates to a pharmaceutical composition and its application in the preparation of products for treating prostatitis, belonging to the fields of biotechnology and medicine preparation. Background technique [0002] Prostatitis is a common disease in adult males, especially chronic non-bacterial prostatitis. Its pathogenesis is still unclear, and there is a lack of effective clinical treatment methods, which has caused great troubles and challenges to patients and doctors. Therefore, finding new and effective drugs for the treatment of prostatitis has important scientific research and clinical value. [0003] Lycopene is an important carotenoid, which contains 11 conjugated double bonds. This high conjugated structure makes it have a strong antioxidant effect. In addition, it also has strong anti-inflammatory, cell growth and metabolism regulation, It can regulate the metabolism of cholesterol, health care, prevent and inhibit tumor. [0...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K31/12A61K31/01A61K9/10A61K47/40A61P13/08
CPCA61K9/10A61K31/01A61K31/12A61K31/352A61K47/40A61P13/08A61P31/04A61K2300/00
Inventor 邢念增赵钦欣杨飞亚陈东孟令全
Owner CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI