Nanofibrous vascular stent material with dual drug loading and stepwise sustained release function and preparation method thereof

A technology of nanofibers and vascular stents, which is applied in the field of new nanofiber vascular stent materials and its preparation, and can solve the problems that there are no nanofiber vascular stent materials with dual-drug loading and step-by-step slow-release functions.

Active Publication Date: 2021-04-30
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are no domestic and foreign literature and patent reports on nanofibrous vascular scaffold materials with dual-drug loading and step-by-step sustained-release functions

Method used

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  • Nanofibrous vascular stent material with dual drug loading and stepwise sustained release function and preparation method thereof

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Experimental program
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Embodiment 1

[0018] The SiO involved in this embodiment 2 The preparation process of / CS-RBS / lgG-PLA-PG new nanofiber vascular stent material, the schematic diagram of the principle of double drug loading and step-by-step sustained release is as follows figure 1 As shown, the specific steps are as follows:

[0019] Weigh 2g of CS with a relative molecular mass of 10,000, add 2mL of acetic acid dropwise to dissolve, then add 50mL of ethanol to disperse, and form a homogeneous solution under magnetic stirring; add 5mLTEOS to the homogeneous solution, and magnetically stir for 6h to obtain Viscous transparent TEOS / CS electrospinning precursor solution. Fill the electrospinning precursor solution into a 5mL plastic syringe for electrospinning; the voltage is (–3kV, 5kV), the spinning solidification distance is 10cm, the needle size is 0.2mm, and the injection speed is 0.2mms –1 , translation speed is 100mm min –1 ; Prepare SiO 2 / CS nanocomposite fiber material, followed by freeze-drying t...

Embodiment 2

[0023] The SiO involved in this embodiment 2 The preparation process of / CS-RBS / lgG-PLA-PG new nanofiber vascular stent material, the schematic diagram of the principle of double drug loading and step-by-step sustained release is as follows figure 1 As shown, the specific steps are as follows:

[0024] Weigh 2g of CS with a relative molecular mass of 10,000, add 2mL of acetic acid dropwise to dissolve, then add 50mL of ethanol to disperse, and form a homogeneous solution under magnetic stirring; add 5mLTEOS to the homogeneous solution, and magnetically stir for 6h to obtain Viscous transparent TEOS / CS electrospinning precursor solution. Fill the electrospinning precursor solution into a 5mL plastic syringe for electrospinning; the voltage is (–3kV, 10kV), the spinning solidification distance is 15cm, the needle size is 0.4mm, and the jetting speed is 0.4mms –1 , translation speed is 200mm min –1 ; Prepare SiO 2 / CS nanocomposite fiber material, followed by freeze-drying tr...

Embodiment 3

[0028] The SiO involved in this embodiment 2 The preparation process of / CS-RBS / lgG-PLA-PG new nanofiber vascular stent material, the schematic diagram of the principle of double drug loading and step-by-step sustained release is as follows figure 1 As shown, the specific steps are as follows:

[0029] Weigh 2g of CS with a relative molecular mass of 10,000, add 2mL of acetic acid dropwise to dissolve, then add 50mL of ethanol to disperse, and form a homogeneous solution under magnetic stirring; add 5mLTEOS to the homogeneous solution, and magnetically stir for 6h to obtain Viscous transparent TEOS / CS electrospinning precursor solution. Fill the electrospinning precursor solution into a 5mL plastic syringe for electrospinning; the voltage is (–3kV, 15kV), the spinning solidification distance is 20cm, the needle size is 0.6mm, and the jetting speed is 0.6mms –1 , translation speed is 300mm min –1 ; Prepare SiO 2 / CS nanocomposite fiber material, followed by freeze-drying tr...

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Abstract

The invention discloses a novel nanofiber vascular stent material with dual-drug loading and step-by-step slow-release functions and a preparation method thereof. The immunoglobulin IgG antibody coupled to the outer layer of the stent material stimulates cells to form epithelial tissue and reduces the formation of thrombus risk; due to the decomposition of polylactic acid in the outer layer of the scaffold, the penicillin loaded by it is slowly released, which inhibits the division and growth of abnormal cells; due to the decomposition of the nitric oxide donor bound to chitosan in the inner layer of the scaffold, the nitric oxide is slowly released freely base, to dilate blood vessels and inhibit tumor growth; the scaffold material has the function of loading penicillin and nitric oxide dual drugs, and releases drugs layer by layer, and is expected to be clinically used as a new type of multifunctional vascular stent implanted in the patient's heart Coronary arteries can achieve many postoperative therapeutic effects such as supporting the lesion blood vessels, reducing the risk of thrombus, inhibiting cytopathy, expanding blood vessels by free radicals, and inhibiting tumor growth.

Description

technical field [0001] The invention belongs to the technical field of preparation of nanometer drug carriers and vascular stent materials, and in particular relates to a novel nanofiber vascular stent material with dual-drug loading and step-by-step slow-release functions and a preparation method thereof. Background technique [0002] After cardiac vasodilation surgery, 30% of patients will face narrowing of blood vessels within six months. Since the patient's blood vessels cannot recover normally after the operation, many cells will be produced to block the blood vessels, resulting in the need for another bypass surgery or angioplasty. In order to avoid vascular narrowing and blockage after surgery, an internal stent needs to be placed in the lesion to support the stenotic occluded vessel, prevent the elastic retraction and reshaping of the vessel, and maintain the smooth blood flow in the lumen. In the early 1980s, doctors envisioned using stents to open up the stiff, na...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/06A61L31/04A61L31/02A61L31/14A61L31/16
CPCA61L31/042A61L31/06A61L31/028A61L31/16A61L31/148A61L31/14A61L2300/102A61L2300/256A61L2300/406A61L2300/42A61L2300/416A61L2300/604C08L5/08C08L67/04
Inventor 桂日军孙泽君金辉
Owner QINGDAO UNIV
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