Device for ink-jet printing gel microsphere, and printing method

Abstract

The invention discloses a device for ink-jet printing a gel microsphere, and a printing method. The device for ink-jet printing the gel microsphere comprises a computer, a three-dimensional motion system, a first ink box, a second ink box, a first multi-orifice piezoelectric spray nozzle and a second multi-orifice piezoelectric spray nozzle. The first ink box and the second ink box are arranged ina pressurization device; the pressurization device is used for providing liquid outlet pressure to the first ink box and the second ink box; the first multi-orifice piezoelectric spray nozzle communicates with a liquid outlet of the first ink box; the second multi-orifice piezoelectric spray nozzle communicates with a liquid outlet of the second ink box; the first multi-orifice piezoelectric spray nozzle and the second multi-orifice piezoelectric spray nozzle are arranged on the three-dimensional motion system; the computer is electrically connected with the three-dimensional motion system, the first multi-orifice piezoelectric spray nozzle and the second multi-orifice piezoelectric spray nozzle; a nd the computer is used for controlling the three-dimensional motion system to move, and isalso used for controlling the first multi-orifice piezoelectric spray nozzle and the second multi-orifice piezoelectric spray nozzle to jet ink. The invention provides the device with high manufacturing efficiency, simplicity and convenience in operation, and capability on accurately controlling the forming of the gel microsphere.

Description

technical field [0001] The invention belongs to the technical field of gel microsphere printing, and in particular relates to an inkjet printing gel microsphere device and a printing method. Background technique [0002] Gel microspheres refer to spherical gels with diameters on the order of microns. In recent years, gel microspheres encapsulated with cells, growth factors, and drugs have been widely used in tissue engineering, biosensors, cancer models, and drug controlled release research. The main reason is that gel microspheres have a larger surface area than other gel structures of the same volume, which is conducive to the exchange of substances between the interior of the gel microspheres and the outside world, and is conducive to the acquisition of cells encapsulated in the gel microspheres from the outside. Oxygen and nutrients needed for growth, waste produced by excretion. In terms of drug loading studies, the size and size uniformity of gel microspheres serious...

AI Technical Summary

Problems solved by technology

The movement of printing droplets in the solution is complicated, which is not convenient to precisely control the formation of gel microspheres, and the sloshing of the liquid surface will reduce the forming accuracy of gel microspheres, and the manufactured gel microspheres often have different shapes and sizes

Compared with single-component inkjet, two-component printing gel microspheres is more conducive to controlling the formation of gel microspheres, but the process is complicated and the manufacturing efficiency is low

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