Device for ink-jet printing gel microsphere, and printing method

A gel microsphere, inkjet printing technology, applied in coating devices, manufacturing auxiliary devices, additive manufacturing, etc., can solve the problems of low manufacturing efficiency, uneven size, complex process, etc., and achieve improved efficiency and uniform size. , the effect of saving materials

Pending Publication Date: 2020-09-01
GENERAL HOSPITAL OF PLA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The movement of printing droplets in the solution is complicated, which is not convenient to precisely control the formation of gel microspheres, and the sloshing of the liquid surface will reduce the forming accuracy of gel microspheres, and the manufactured gel m

Method used

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  • Device for ink-jet printing gel microsphere, and printing method
  • Device for ink-jet printing gel microsphere, and printing method
  • Device for ink-jet printing gel microsphere, and printing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Two-component solution is respectively 4% (w / v) sodium alginate DPBS aqueous solution and 4% (w / v) calcium chloride deionized aqueous solution, the preparation method of two kinds of solutions is:

[0049] At room temperature, 16 g of sodium alginate A0682 powder was dissolved in 400 ml of DPBS aqueous solution, and magnetically stirred at 400 r / min for 12 hours to prepare a sodium alginate DPBS aqueous solution with a concentration of 4% (w / v). Put the prepared sodium alginate solution into a vertical pressure steam sterilizer and heat it to 125°C for 25 minutes. After the solution was cooled to room temperature, it was filtered through a filter membrane with a pore size of 1 μm.

[0050] At room temperature, 16g of calcium chloride powder was dissolved in 400ml of deionized water, and magnetically stirred at a speed of 200r / min for 30min. Then add 0.01% (v / v) fluorine-containing nonionic surfactant to the calcium chloride aqueous solution FC~4430, magnetic stirring...

Embodiment 2

[0056] Two-component solutions are respectively 3% (w / v) sodium alginate DPBS aqueous solution and 2% (w / v) calcium chloride deionized aqueous solution, and the preparation method of two kinds of solutions is:

[0057] At room temperature, 12 g of sodium alginate A0682 powder was dissolved in 400 ml of DPBS aqueous solution, and magnetically stirred at 400 r / min for 8 hours to prepare a sodium alginate DPBS aqueous solution with a concentration of 3% (w / v). Put the prepared sodium alginate solution into a vertical pressure steam sterilizer and heat it to 125°C for 25 minutes. After the solution was cooled to room temperature, it was filtered through a filter membrane with a pore size of 1 μm.

[0058] At room temperature, 8 g of calcium chloride powder was dissolved in 400 ml of deionized water, and magnetically stirred at a speed of 200 r / min for 30 min. Then add 0.01% (v / v) fluorine-containing nonionic surfactant to the calcium chloride aqueous solution FC~4430, magnetic ...

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Abstract

The invention discloses a device for ink-jet printing a gel microsphere, and a printing method. The device for ink-jet printing the gel microsphere comprises a computer, a three-dimensional motion system, a first ink box, a second ink box, a first multi-orifice piezoelectric spray nozzle and a second multi-orifice piezoelectric spray nozzle. The first ink box and the second ink box are arranged ina pressurization device; the pressurization device is used for providing liquid outlet pressure to the first ink box and the second ink box; the first multi-orifice piezoelectric spray nozzle communicates with a liquid outlet of the first ink box; the second multi-orifice piezoelectric spray nozzle communicates with a liquid outlet of the second ink box; the first multi-orifice piezoelectric spray nozzle and the second multi-orifice piezoelectric spray nozzle are arranged on the three-dimensional motion system; the computer is electrically connected with the three-dimensional motion system, the first multi-orifice piezoelectric spray nozzle and the second multi-orifice piezoelectric spray nozzle; a nd the computer is used for controlling the three-dimensional motion system to move, and isalso used for controlling the first multi-orifice piezoelectric spray nozzle and the second multi-orifice piezoelectric spray nozzle to jet ink. The invention provides the device with high manufacturing efficiency, simplicity and convenience in operation, and capability on accurately controlling the forming of the gel microsphere.

Description

technical field [0001] The invention belongs to the technical field of gel microsphere printing, and in particular relates to an inkjet printing gel microsphere device and a printing method. Background technique [0002] Gel microspheres refer to spherical gels with diameters on the order of microns. In recent years, gel microspheres encapsulated with cells, growth factors, and drugs have been widely used in tissue engineering, biosensors, cancer models, and drug controlled release research. The main reason is that gel microspheres have a larger surface area than other gel structures of the same volume, which is conducive to the exchange of substances between the interior of the gel microspheres and the outside world, and is conducive to the acquisition of cells encapsulated in the gel microspheres from the outside. Oxygen and nutrients needed for growth, waste produced by excretion. In terms of drug loading studies, the size and size uniformity of gel microspheres serious...

Claims

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Application Information

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IPC IPC(8): B29C64/112B29C64/209B29C64/393B33Y30/00B33Y50/02
CPCB33Y30/00B33Y50/02B29C64/112B29C64/209B29C64/393
Inventor 杨思明连芩焦天赵廷泽王慧超李涤尘梁晋
Owner GENERAL HOSPITAL OF PLA
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