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Chitosan oligosaccharide oral liquid and application thereof in preparation of weight-reducing drugs

A technology of chitosan oligosaccharide oral liquid and oral liquid is applied in the application field of chitosan oligosaccharide oral liquid and preparation of slimming drugs, which can solve the problems of poor stability of chitosan oligosaccharide preparation, unstable preparation and small molecular weight, etc. Stable quality and efficacy, increasing user population, reducing high fat content and fat/body ratio

Active Publication Date: 2020-09-04
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Chitosan oligosaccharide is degraded from chitin, which has good water solubility, low viscosity, small molecular weight, easy absorption and utilization, and can be degraded. The stability of oligosaccharide preparations is not good. Therefore, it is of great significance to develop a new formulation of chitosan oligosaccharides to solve the technical problem of unstable preparations and to fully exert the weight loss effect.

Method used

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  • Chitosan oligosaccharide oral liquid and application thereof in preparation of weight-reducing drugs
  • Chitosan oligosaccharide oral liquid and application thereof in preparation of weight-reducing drugs
  • Chitosan oligosaccharide oral liquid and application thereof in preparation of weight-reducing drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1, chitosan oligosaccharide oral liquid of the present invention

[0028] formula:

[0029] Oligochitosan 30g sodium benzoate 1g Potassium sorbate 0 L-fucose 4g Sodium carboxymethyl cellulose 1g Citric Acid - Sodium Citrate 0.5g glacial acetic acid 0 aspartame 1g xylitol 0

[0030] The preparation method includes the following steps: take an appropriate amount of purified water, add chitosan oligosaccharides, preservatives, buffers and stabilizers according to the prescribed amount, shake in a constant temperature air bath until the dissolution and inclusion are complete, then add flavoring agents, and finally adjust pH to 4.5, that's it.

Embodiment 2

[0031] Embodiment 2, chitosan oligosaccharide oral liquid of the present invention

[0032] formula:

[0033] Oligochitosan 35g sodium benzoate 0.5g Potassium sorbate 0.5g L-fucose 4.8g Sodium carboxymethyl cellulose 1.2g Citric Acid - Sodium Citrate 1g glacial acetic acid 0 aspartame 0.5g xylitol 0.5g

[0034] The preparation method includes the following steps: take an appropriate amount of purified water, add chitosan oligosaccharides, preservatives, buffers and stabilizers according to the prescribed amount, shake in a constant temperature air bath until the dissolution and inclusion are complete, then add flavoring agents, and finally adjust pH to 5.5, that's it.

Embodiment 3

[0035] Embodiment 3, chitosan oligosaccharide oral liquid of the present invention

[0036] formula:

[0037] Oligochitosan 40g sodium benzoate 1g Potassium sorbate 1g L-fucose 5.6g Sodium carboxymethyl cellulose 1.4g Citric Acid - Sodium Citrate 1g glacial acetic acid 0 aspartame 1g xylitol 1g

[0038] The preparation method includes the following steps: take an appropriate amount of purified water, add chitosan oligosaccharides, preservatives, buffers and stabilizers according to the prescribed amount, shake in a constant temperature air bath until the dissolution and inclusion are complete, then add flavoring agents, and finally adjust pH to 6.5, that's it.

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PUM

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Abstract

The invention relates to the technical field of oral liquid, and provides chitosan oligosaccharide oral liquid and application thereof in preparation of weight-reducing drugs. The oral liquid comprises the following raw material in parts by weight: 30-45 parts of chitosan oligosaccharide, 1-2 parts of a preservative, 0.5-1.5 parts of a buffer agent, 1-3 parts of a flavoring agent and 5-8 parts ofa stabilizer. The chitosan oligosaccharide oral liquid prepared by the invention is quick to absorb, quick to take effect, safe, effective, stable in preparation, stable in quality and curative effectand suitable for industrial production.

Description

technical field [0001] The invention relates to the technical field of oral liquids, in particular to a chitosan oligosaccharide oral liquid and its application in the preparation of weight-loss drugs. Background technique [0002] Obesity refers to a certain degree of obvious overweight and thick fat layer, which is a state caused by excessive accumulation of body fat, especially triglycerides. Excessive body fat accumulation due to excessive food intake or changes in body metabolism results in excessive weight gain and causes human pathology, physiological changes or latency. Over the past 50 years, the prevalence of obesity has increased worldwide, reaching epidemic proportions. Obesity is a major health challenge as it substantially increases the risk of type 2 diabetes, fatty liver, hypertension, myocardial infarction, stroke, dementia, osteoarthritis, obstructive sleep apnea, and some cancers, thus contributing to quality of life and Declining life expectancy has bec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/38A61K47/26A61K31/702A61K31/722A61P3/04
CPCA61K9/0095A61K31/702A61K31/722A61K47/26A61K47/38A61P3/04
Inventor 苏政权白研曹华
Owner GUANGDONG PHARMA UNIV
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