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Preparation method of hierarchical porous metal-organic framework material for drug-loaded sustained release

A metal-organic framework, multi-level pore technology, applied in pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve the problems of decreased stability of MOFs, unsuitable for biomaterial preparation, interlaced framework networks, etc., to promote nucleation. Effect of crystallization process, structural stability, high specific surface area

Active Publication Date: 2022-02-08
HUAQIAO UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for most hierarchically porous MOFs, the removal of guest molecules or post-treatment will also lead to the interweaving or destruction of the framework network, resulting in a decrease in the stability of MOFs.
In addition, most templates have certain biological toxicity and are difficult to remove during the preparation process, so they are not suitable for the preparation of biological materials.

Method used

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  • Preparation method of hierarchical porous metal-organic framework material for drug-loaded sustained release
  • Preparation method of hierarchical porous metal-organic framework material for drug-loaded sustained release
  • Preparation method of hierarchical porous metal-organic framework material for drug-loaded sustained release

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Preparation of Metal Organic Framework (HP-Cu-BTC for short)

[0026] The preparation method of the metal-organic framework material for drug-loaded sustained release of the present invention comprises the following steps:

[0027] (1) Take 0.5mL TX-100 and 3mL 1-butyl-3-methylimidazolium hexafluoroborate successively into the reaction flask, mix and stir for 10min, then add 9mL propylene glycol, stir for 30min to obtain an ionic liquid microemulsion.

[0028] (2) 188mg metal salt anhydrous copper nitrate [Cu(NO 3 ) 2 ], 104 mg of organic ligand trimesic acid were poured into the ionic liquid microemulsion in turn, stirred for 1 to 2 min, then transferred to a high-pressure reactor, and fed with CO at a pressure of 3 MPa 2 , reacted for 3 hours, after the reaction, washed with ethanol for 3 times, and then dried in an oven at 60° C., and HP-Cu-BTC was obtained after drying.

[0029] The SEM figure of metal organic material (HP-Cu-BTC) of the present invention is a...

Embodiment 2

[0036] 1. Preparation of HP-Cu-BTC

[0037] The preparation method of the hierarchically porous metal-organic framework material for drug-loaded sustained release of the present invention comprises the following steps:

[0038] (1) Take 1mL TX-100 and 4mL 1-butyl-3-methylimidazolium tetrafluorophosphate successively into the reaction flask, mix and stir for 10min, then add 8mL ethanol, and stir for 30min.

[0039] (2) 250mg of anhydrous copper sulfate [Cu(SO 4 ) 2], 208mg of trimesic acid were poured into the ionic liquid microemulsion in turn, stirred for 1-2min, transferred to a high-pressure reactor, and 5MPa CO 2 , Reaction 2h. After the reaction, it was washed with ethanol for three times, and dried in an oven at 60° C. to obtain HP-Cu-BTC after drying.

[0040] N of HP-Cu-BTC 2 Physical adsorption isotherm curves and pore size distribution diagrams, such as figure 2 As shown, its BET specific surface area is 380m 2 / g without CO 2 The BET specific surface area o...

Embodiment 3

[0046] 1. Preparation of HP-Cu-BTC

[0047] The preparation method of the hierarchically porous metal-organic framework material for drug-loaded sustained release of the present invention comprises the following steps:

[0048] (1) Take 1.2mL TX-100 and 2mL 1-butyl-3-methylimidazolium hexafluorophosphate successively into the reaction flask, mix and stir for 20min, then add 8mL ethylene glycol, and stir for 30min.

[0049] (2) 90mg of anhydrous copper acetate [Cu(OAC) 2 ], 52mg of trimesic acid were poured into the ionic liquid microemulsion in turn, stirred for 1-2min, transferred to a high-pressure reactor, and 5MPa CO 2 , Reaction 3h. After the reaction, it was washed with ethanol for three times, and dried in an oven at 60° C. to obtain HP-Cu-BTC after drying.

[0050] 2. Loading and sustained release test of HP-Cu-BTC

[0051] Further, 20 mg of HP-Cu-BTC was weighed and added to 2 mg / mL doxorubicin hydrochloride (DOX·HCl) methanol solution, stirred in the dark for 12 ...

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Abstract

The invention discloses a preparation method of a hierarchically porous metal-organic framework material for drug-loaded sustained release. The synthetic raw materials of HP-Cu-BTC are sequentially dissolved in an ionic liquid microemulsion containing a continuous phase and a dispersed phase, and then passed through Into CO 2 High-pressure gas reacts at room temperature to obtain HP-Cu-BTC for drug loading and sustained release. The preparation method is simple in operation, good in repeatability, short in time consumption, and the process route is green and environmentally friendly, and the prepared HP-Cu-BTC product has a multi-level porous structure, large specific surface area, high drug loading capacity, and can ensure the long-term effect of the drug Release slowly.

Description

technical field [0001] The invention belongs to the field of preparation of drug loading and sustained release carriers, in particular to a method for preparing a metal organic framework material (HP-Cu-BTC for short) used for drug loading and sustained release. Background technique [0002] Usually, due to many inherent shortcomings of drugs in the body, such as unstable physiological conditions, low solubility, and large toxic and side effects, the therapeutic effect of many clinical drugs is greatly reduced, and it also has a negative impact on human health. In recent years, in order to meet the needs of efficient drug utilization, drug sustained release has attracted much attention in the field of drug research and has become one of the important research directions. Significance. [0003] The drug carrier material is a key part of the drug sustained release system. Existing carrier materials are mainly divided into inorganic materials and organic materials. Inorganic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G83/00C08J9/00A61K47/10C08L87/00
CPCC08G83/008C08J9/00A61K47/10C08J2387/00
Inventor 詹国武曾小丽周树锋苏蕊石璇程奕璇香含林博楷
Owner HUAQIAO UNIVERSITY
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