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The application of Morinda

A technology of Morindatin and medicine, which is applied in the application field of Morindatin, can solve problems that have not been reported yet, and achieve the effect of preventing and treating hypertensive nephropathy

Active Publication Date: 2021-07-13
广州康臣药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Morinda officinalis can be isolated from Morinda officinalis, and has antidepressant, antistress, anti-myocardial ischemia-reperfusion injury, immune-stimulating activity, and spermatogenesis-promoting effects, but its application in hypertension and nephropathy drugs , has not been reported yet,

Method used

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  • The application of Morinda
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  • The application of Morinda

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1, the preparation of Morinda officinalis

[0042] According to the following preparation method, Morinda officinalis was extracted, separated and purified to obtain Morinda officinalis:

[0043] Take 1.0kg of Morinda officinalis medicinal material, crush it into coarse powder, pass through a 50-mesh sieve, add 15L 40% ethanol to soak for 24 hours, reflux extraction in 90ºC water bath for 2 hours, filter, add 10L 40% ethanol to the filter residue and extract again for 1 hour, filter , combine the filtrate, concentrate under reduced pressure to an appropriate volume, pass through an activated carbon column to remove impurities, add it to D-900 macroporous resin, wash with water until the sugar color reaction of the eluent is negative, combine the eluent, and concentrate under reduced pressure to After thickening the paste, dry it under reduced pressure, add 5 times the amount of water to dissolve in a water bath, filter while it is hot, and after the filtrat...

Embodiment 2

[0044] Embodiment 2, the influence experiment of Morinda officinalis on renal intrarenal pressure

[0045] In this example, a renal perfusion system was used to detect changes in renal intrarenal pressure (simulated blood pressure in vitro), and valsartan was used as a positive drug to observe the effect of bacijia on it, and to investigate whether it had a hypotensive effect.

[0046] The content of the experiment is as follows:

[0047] 1. Test materials and instruments

[0048] SPF grade rats, purchased from Southern Medical University, license number SCXK (Guangdong) 2016-0041;

[0049] Norepinephrine bitartrate, lot#: 1805191, Tianjin Jinyao Amino Acid Co., Ltd.;

[0050] Valsartan, lot#: SML0142, Sigma;

[0051] The rest of the reagents were of domestic analytical grade.

[0052] Electronic analytical balance, BS224S / CB-25A, Beijing Sartorius Instrument System Co., Ltd.;

[0053] Isolated kidney perfusion device, TIS3852, Kent Company;

[0054] Four-channel recor...

Embodiment 3

[0071] Embodiment 3, the experiment of the influence of Morinda on the activity of ACE

[0072] In this example, the ACE derived from porcine lung was used to observe the effect of Morindatin on its enzyme activity, and to investigate whether it had a hypotensive effect on it.

[0073] The content of the experiment is as follows:

[0074] 1. Test materials and instruments

[0075] Hippuric acid (HA), Lot: F1212042, Aladdin;

[0076] Hippuryl histidyl leucine (HHL), Lot: SLBW5368, Sigma;

[0077] DEAE seplife FF, lot#: 20180116101, Xi'an Lanxiao Technology New Materials Co., Ltd.)

[0078] Triton x-100, lot#: 125346, Shanghai GBS Gene Technology Co., Ltd.;

[0079] Dialysis bag, MW: 14000±2000;

[0080] BCA kit, lot#: 041318180711, Biyuntian;

[0081] Tris, lot#: 0922S0715, Solarbio;

[0082] Bovine serum albumin, BSA, lot#: SL27152202, Shanghai Lianshuo Biotechnology Co., Ltd.;

[0083] The rest of the reagents were of domestic analytical grade.

[0084] Fresh pig l...

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Abstract

The present invention relates to the application of Morinda, in particular to the application of Morinda in the preparation of medicines for preventing and treating hypertension and / or nephropathy. The nephropathy is nephropathy caused by essential hypertension or nephropathy caused by other reasons. The inventors of the present invention have found through a large number of experiments that Morinda can prevent and treat hypertension as well as nephropathy. In particular, it has been verified on SHR hypertensive nephropathy model rats that the drug can effectively prevent and treat hypertensive nephropathy.

Description

technical field [0001] The invention relates to the technical field of medicine and pharmacy, in particular to the application of bajijia. Background technique [0002] The onset of hypertension is closely related to the kidney, which is not only an important organ for blood pressure regulation, but also one of the main target organs damaged by hypertension. Kidney damage secondary to hypertension, namely hypertensive nephropathy, is one of the most important complications of hypertension. According to statistics, the incidence of hypertensive nephropathy is 42%, second only to cardiac complications, and 18% of patients with hypertensive nephropathy eventually develop chronic renal failure. In my country, patients with hypertensive nephropathy account for the third place in the number of patients with renal failure peritoneal dialysis and hemodialysis, second only to chronic nephritis and diabetes, and seriously endanger the life and quality of life of hypertensive patients...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7016A61K36/746A61P9/12A61P13/12
CPCA61K31/7016A61K36/746A61P9/12A61P13/12
Inventor 何宝段婷婷王汝上朱荃李政海麦瑞芬高俊飞万江山钟铖顾斐程慧荃陶俊妃黄艳霞列倍锋
Owner 广州康臣药业有限公司
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