Method for preparing medical adhesive from alpha-alkyl cyanoacrylate monomer

Abstract

The invention belongs to the field of biological materials, and specifically relates to a method for preparing a medical adhesive from an alpha-alkyl cyanoacrylate monomer. According to the invention,the medical adhesive prepared from the alpha-alkyl cyanoacrylate monomer, formaldehyde, a catalyst, namely piperidine, lauryl sodium sulfate, a basic catalyst, namely phosphoric acid, purified water,a plasticizer, namely tricresyl phosphate, a polymerization inhibitor, namely hydroquinone, ethyl cyanoacetate, isobutyl alcohol, phthalate and an acid catalyst has the following advantages: the compatibility of the medical adhesive can be improved; and the bonding capacity of the medical adhesive can be reduced at the same time. The medical adhesive provided by the invention is mainly used for solving the problems of low reaction speed of reagents and poor medical bonding capacity due to poor compatibility among the reagents in the preparation process of a conventional medical adhesive, andthe problem of layering of a stock solution in a three-neck flask due to the facts that methyl silicone oil in an oil pan is uniformly heated and the stock solution in the three-neck flask is heated unevenly in the process that the three-neck flask is subjected to distillation heat conduction by the methyl silicone oil.

Description

technical field [0001] The invention belongs to the field of biological materials, in particular to a method for preparing medical glue from an alpha-cyanoacrylate alkyl ester monomer. Background technique [0002] α-isobutyl cyanoacrylate, n-butyl α-cyanoacrylate, and n-octyl α-cyanoacrylate are three α-cyanoacrylate alkyl ester monomers, due to the presence of cyano [-CN] and carbonyl [ -C=O] Two electron-withdrawing groups, which can react with anionic groups such as carbonyl [-OH] and amino groups [-NH2] in trace moisture on the skin surface and body fluids, and can quickly trigger isobutyl α-cyanoacrylate The monomer polymerizes, and after 5-15 seconds, a protective film is formed on the skin surface, which can tightly adhere the skin and isolate the tissue from bacteria. The bonding strength of the adhesive film is greater than the natural tension of the wound, which can tightly bond the skin, and play the role of immediate hemostasis and coagulation under the action ...

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Problems solved by technology

[0005] In order to make up for the deficiencies in the prior art, the technical problem to be solved by the present invention is to provide a method for preparing medical glue from α-alkyl cyanoacrylate monomer. Due to the poor compatibility between the reagents, the reaction speed of the reagents is slow, and the bonding ability of the medical ones is not strong. At the same time, during the distillation of the stock solution in the there-necked flask, due to the Methyl silicone oil is evenly heated. During the process of distilling and conducting heat conduction to the three-necked flask with methyl silicone oil, the stock solution in the three-necked flask will be heated unevenly, which will lead to stratification of the stock solution in the three-necked flask. layer, which will reduce the reaction speed of various reagents in the stock solution, thereby reducing the process problem of the exchange reaction of α-alkyl cyanoacrylate

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