Compound traditional Chinese medicine and preparation method and application thereof

A technology of compound traditional Chinese medicine and medicine, which is applied in the field of research and development of pharmaceutical products, can solve the problems of drug disease relapse, limited curative effect, and ineffectiveness, and achieve the effects of facilitating recovery, reducing content, and improving fatty degeneration

Pending Publication Date: 2020-10-02
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In recent years, although some drugs for the prevention and treatment of liver damage have been developed, long-term use may hav...

Method used

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  • Compound traditional Chinese medicine and preparation method and application thereof
  • Compound traditional Chinese medicine and preparation method and application thereof
  • Compound traditional Chinese medicine and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Recipe: 50g mouse bougainvillea, 20g Paimoensis, 30g piercing stone

[0021] (1) According to the above-mentioned formula quantity, pulverize the arborescens, the grass of the penis, and the crushed stone to 20-100 mesh and mix to obtain the material;

[0022] (2) With the material obtained in step (1), after soaking with 95% ethanol (1000g) for 1h, reflux extraction for 3h, filter and collect the extract, filter residue was then reflux with 95% ethanol (800g) for 2h, and combine the two extracts , concentrated to a concentration of 1g / mL crude drug amount, bottled, sealed, to obtain the compound Chinese medicine extract (hereinafter referred to as extract A, its fingerprint see figure 1 ).

Embodiment 2

[0024] Recipe: 50g mouse bougainvillea, 20g Paimoensis, 30g piercing stone

[0025] (1) According to the above-mentioned formula quantity, pulverize the arborescens, the grass of the penis, and the crushed stone to 20-100 mesh and mix to obtain the material;

[0026] (2) After soaking the material obtained in step (1) with 95% ethanol (1000g) for 3h, reflux extraction for 2h, filter and collect the extract, and filter residue with 95% ethanol (800g) for reflux extraction for 1.5h, and combine the two extractions solution, concentrated to a concentration of 1g / mL crude drug amount, bottled, sealed, to obtain the compound Chinese medicine extract (hereinafter referred to as extract B, fingerprint and figure 1 consistent).

Embodiment 3

[0028] Recipe: 40g mouse bougainvillea, 10g pachymos, 20g piercing stone

[0029] (1) According to the above-mentioned formula quantity, pulverize the arborescens, the grass of the penis, and the crushed stone to 20-100 mesh and mix to obtain the material;

[0030] (2) With the material obtained in step (1), after soaking with 95% ethanol (700g) for 1h, reflux extraction for 3h, filter and collect the extract, filter residue is then reflux with 95% ethanol (560g) for 2h, and combine the two extracts , concentrated to a concentration of 1g / mL crude drug amount, bottled and sealed to obtain the compound Chinese medicine extract (hereinafter referred to as extract C).

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Abstract

The invention relates to a compound traditional Chinese medicine and a preparation method and application thereof. The compound traditional Chinese medicine consists of the following raw materials inparts by weight: 4-6 parts of acanthus ilicifolius, 1-3 parts of phyllodium pulchellum and 2-4 parts of radix cudraniae, preferably 5 parts of acanthus ilicifolius, 2 parts of phyllodium pulchellum and 3 parts of the radix cudraniae. The invention relates to an application of the compound traditional Chinese medicine or compound extracts to preparation of medicines for nourishing the liver. The compound traditional Chinese medicine disclosed by the invention has the effect of protecting the liver, can notably reduce the content of oxygen-derived free radicals and lipid peroxides in liver tissue of rats, can improve SOD activity, can improve pathologic conditions of steatosis, vacuolation denaturation, injury, karyorrhexis and the like of liver cells, and can facilitate rehabilitation of liver injury.

Description

technical field [0001] The invention belongs to the technical field of research and development of pharmaceutical products. The invention relates to a compound traditional Chinese medicine, a preparation method and application thereof. Background technique [0002] The liver is the largest substantial organ in the body, which undertakes important functions of digestion, metabolism, detoxification and secretion, and plays an important protective role in the body. Liver injury is a common liver disease, often accompanied by metabolic and synthetic dysfunction, leading to serious diseases such as liver fibrosis, cirrhosis, hepatitis, and even liver cancer, which seriously affects human health. Acute liver injury is a common clinical liver disease. In mild cases, it manifests as elevated serum transaminases and bilirubin, which can lead to chronic hepatitis, liver failure, hepatic encephalopathy and other diseases. Studies have shown that acute liver injury may be caused by va...

Claims

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Application Information

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IPC IPC(8): A61K36/60A61P1/16
CPCA61K36/19A61K36/48A61K36/60A61K2236/333A61K2236/39A61P1/16A61K2300/00
Inventor 王长云邵长伦信兰婷乐世俊任夏赵庆张梦启
Owner OCEAN UNIV OF CHINA
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