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Easy-to-dissolve blocky CBD crystal form I and preparation method thereof

A block and crystal form technology, which is applied in the field of block CBD crystal form I and its preparation, can solve the problems of affecting downstream grinding and preparation dissolution rate, affecting agglomeration, bulk density, affecting product appearance and purity, etc.

Pending Publication Date: 2020-10-20
YUNNAN AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the embodiment of the present invention is to provide a block CBD crystal form I that is easy to dissolve, so as to solve the problem that the existing CBD raw material products affect the downstream grinding and preparation and other links, as well as the dissolution rate in the downstream production links. The product affects the problem of agglomeration and bulk density during storage, and the existing CBD raw material products affect the appearance and purity of the product, etc.

Method used

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  • Easy-to-dissolve blocky CBD crystal form I and preparation method thereof
  • Easy-to-dissolve blocky CBD crystal form I and preparation method thereof
  • Easy-to-dissolve blocky CBD crystal form I and preparation method thereof

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Effect test

Embodiment 1

[0041] To prepare an easily soluble bulk CBD crystal form I, follow the steps below:

[0042] 1. Preparation of crude CBD:

[0043] 1) Dried the flowers and leaves of industrial hemp, crushed them, and extracted with absolute ethanol to obtain an extract, wherein, every 1Kg of flowers and leaves of industrial hemp was extracted with 2L of absolute ethanol;

[0044] 2) Concentrating the extract to obtain an extract and reclaiming absolute ethanol;

[0045] 3) Water-sink the extract to remove impurities to obtain a water-sink liquid;

[0046] 4) Centrifuge the water sedimentation liquid and add absolute ethanol to the precipitate, and obtain the ethanol solution of the precipitate after dissolving;

[0047] 5) After evaporating and cooling the ethanol solution of the precipitate, a supersaturated precipitate is obtained;

[0048] 6) The obtained solid is washed with purified water or ethanol, mixed with pure water, and dried to obtain the crude CBD.

[0049] 2. Preparation o...

Embodiment 2

[0054]To prepare an easily soluble bulk CBD crystal form I, follow the steps below:

[0055] 1. Preparation of crude CBD:

[0056] 1) Dried the flowers and leaves of industrial hemp, crushed them, and extracted with absolute ethanol to obtain an extract, wherein, every 1Kg of flowers and leaves of industrial hemp was extracted with 2L of absolute ethanol;

[0057] 2) Concentrating the extract to obtain an extract and reclaiming absolute ethanol;

[0058] 3) Water-sink the extract to remove impurities to obtain a water-sink liquid;

[0059] 4) Centrifuge the water sedimentation liquid and add absolute ethanol to the precipitate, and obtain the ethanol solution of the precipitate after dissolving;

[0060] 5) After evaporating and cooling the ethanol solution of the precipitate, a supersaturated precipitate is obtained;

[0061] 6) The obtained solid is washed with purified water or ethanol, mixed with pure water, and dried to obtain the crude CBD.

[0062] 2. Preparation of...

Embodiment 3

[0067] To prepare an easily soluble bulk CBD crystal form I, follow the steps below:

[0068] 1. Preparation of crude CBD:

[0069] 1) Dried the flowers and leaves of industrial hemp, crushed them, and extracted with absolute ethanol to obtain an extract, wherein, every 1Kg of flowers and leaves of industrial hemp was extracted with 2L of absolute ethanol;

[0070] 2) Concentrating the extract to obtain extract and reclaiming ethanol;

[0071] 3) Water-sink the extract to remove impurities to obtain a water-sink liquid;

[0072] 4) Centrifuge the water sedimentation liquid and add absolute ethanol to the precipitate, and obtain the ethanol solution of the precipitate after dissolving;

[0073] 5) After evaporating and cooling the ethanol solution of the precipitate, a supersaturated precipitate is obtained;

[0074] 6) The obtained solid is washed with purified water or ethanol, mixed with pure water, and dried to obtain the crude CBD.

[0075] 2. Preparation of CBD bulk c...

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Abstract

The invention discloses an easy-to-dissolve blocky CBD crystal form I and a preparation method thereof. The preparation method comprises the following steps: firstly, suspending a CBD crude product ina mixed solvent with the volume ratio of ethanol to water being (1: 1) to (2: 1) to form a suspension with the mass-volume ratio (g / ml) being (1: 20) to (1: 80); heating the obtained suspension, keeping the temperature, and dropwise adding an inorganic alkali liquor into the suspension under a stirring condition for alkalization until the pH value is 9-11 and the suspension is completely dissolved; dropwise adding an inorganic acid aqueous solution for acidification until the pH value is 2-4, stopping heating, standing, and slowly cooling to perform filling crystallization; and finally, sequentially carrying out suction filtration, washing the obtained filter cake, and drying under reduced pressure to obtain the blocky CBD crystal I. The prepared easy-to-dissolve blocky CBD crystal form Iis in a cubic block shape, the purity, namely the content of CBD is larger than 97%, the easy-to-dissolve blocky CBD crystal form I is easy to dissolve in ethyl alcohol, and the diffraction peak intensity of an X-ray powder diffraction pattern of the blocky CBD crystal form I at the position of 2theta being 31.754 is 100%.

Description

technical field [0001] The invention belongs to the technical field of medicinal chemistry, and relates to an easily soluble block CBD crystal form I and a preparation method thereof. Background technique [0002] CBD (cannabidiol), that is, cannabidiol, is a pure natural ingredient extracted from the flowers and leaves of the cannabis plant, and its molecular formula is C 21 h 30 o 2 , the molecular weight is 314.46. CBD is a non-addictive component in cannabis, which can block the adverse effects of certain polyphenols on the human nervous system, and has a series of physiological activities such as blocking breast cancer metastasis, treating epilepsy, anti-rheumatoid arthritis, and anti-insomnia Function. In addition, CBD has anti-inflammatory, bactericidal, analgesic, anti-anxiety, anti-oxidation and other effects, and also has potential medical value in the treatment of schizophrenia and Alzheimer's disease. Therefore, CBD can be widely used in medicine, food, cosm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C39/23C07C37/68C07C37/84
CPCC07C39/23C07C37/004C07C37/685C07C37/84C07B2200/13C07C2601/16
Inventor 李靖李崧邓临新王静李勃达
Owner YUNNAN AGRICULTURAL UNIVERSITY
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