Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of anti-fibrosis drug sustained-release coating and preparation method thereof

An anti-fibrosis and drug technology, applied in coatings, drug delivery, pharmaceutical formulations, etc., can solve the problems of complex preparation process and poor biocompatibility, and achieve simple preparation method, good biocompatibility, control Effect of early release rate

Active Publication Date: 2022-02-25
SECOND AFFILIATED HOSPITAL OF COLLEGE OF MEDICINEOF XIAN JIAOTONG UNIV +1
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the problems of the existing slow-release coating technology, such as obvious early burst release, complex preparation process and poor biocompatibility, the present invention utilizes the characteristics of amyloid protein assembly and adhesion on solid surfaces to provide an anti-fibrosis Self-assembly of the surface of drug particles to form a stable amyloid-like protein film, which is used as a slow-release coating on the surface of various medical implants and its preparation method

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of anti-fibrosis drug sustained-release coating and preparation method thereof
  • A kind of anti-fibrosis drug sustained-release coating and preparation method thereof
  • A kind of anti-fibrosis drug sustained-release coating and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 1. Add 0.5g of bovine serum albumin, 0.7g of tris(2-carboxyethyl)phosphine hydrochloride and 0.1g of hyaluronic acid into 100mL of deionized water, mix well, and adjust the pH to 4.5 with sodium hydroxide to obtain impregnation liquid; the concentration of bovine serum albumin in the soaking liquid is 5 mg / mL, the concentration of tris (2-carboxyethyl) phosphine hydrochloride is 7 mg / mL, and the concentration of hyaluronic acid is 1 mg / mL.

[0034] 2. Alternately clean the silicone catheter with ethanol and acetone, ultrasonically clean it with deionized water for 10 minutes, blow dry with nitrogen, and then spray and fix 10 mg / mL rapamycin ethanol solution on the surface of the silicone catheter to obtain rapamycin-coated The silicone catheter of the drug drug, wherein the spraying process parameters are: ultrasonic frequency is 120kHz, ultrasonic power is 2W, the flow rate of ultrasonic spraying solution is 1mL / min, the rotation speed of the driving equipment is 300r / m...

Embodiment 2

[0038]In step 1 of this example, add 1 g of bovine serum albumin, 0.7 g of tris(2-carboxyethyl)phosphine hydrochloride and 0.4 g of hyaluronic acid into 100 mL of deionized water, mix well, and adjust the pH with sodium hydroxide To 4.5, obtain the dipping solution; the concentration of bovine serum albumin in the dipping solution is 10mg / mL, the concentration of tris (2-carboxyethyl) phosphine hydrochloride is 7mg / mL, the concentration of hyaluronic acid is 4mg / mL mL. Other steps were the same as in Example 1, forming a sustained-release coating of rapamycin on the surface of the silicone catheter.

Embodiment 3

[0040] In step 1 of this example, add 0.5 g of bovine serum albumin, 0.7 g of tris(2-carboxyethyl)phosphine hydrochloride and 0.1 g of alginic acid into 100 mL of deionized water, mix well, and adjust the pH with sodium hydroxide To 4.5, obtain the soaking solution; the concentration of bovine serum albumin in the soaking solution is 5 mg / mL, the concentration of tris (2-carboxyethyl) phosphine hydrochloride is 7 mg / mL, and the concentration of alginic acid is 1 mg / mL . Other steps were the same as in Example 1, forming a sustained-release coating of rapamycin on the surface of the silicone catheter.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a slow-release coating for anti-fibrosis drugs and a preparation method thereof. Proteins, protein modifiers and additives are added into deionized water, mixed evenly, and the pH is adjusted to 4.0-10.0 with a pH regulator to form an impregnated coating. solution; the anti-fibrosis drug solution is sprayed and fixed on the surface of the medical material, and the anti-fibrosis drug slow-release coating can be formed after standing in the impregnation solution. The preparation method of the invention is simple and applicable to the surfaces of various medical devices, especially biological inert substrates, and can be realized by simple dip coating without complicated surface modification technology. The slow-release coating of the invention has good controllability, stable drug release, can effectively control the early release rate of the drug, and prevent the toxic effect caused by the early rapid release after implantation. In addition, the main components of the slow-release coating of the present invention are proteins and natural polymer substances, are non-toxic and non-irritating, have good biocompatibility, and have broad application prospects in local drug delivery.

Description

technical field [0001] The invention belongs to the technical field of drug sustained release, and in particular relates to an anti-fibrosis drug sustained release coating and a preparation method thereof. Background technique [0002] The damage and repair of tissues and organs is one of the problems faced by the medical field today. The best way to repair tissues should be repaired by the same kind of cells to restore the shape and function of the tissues. However, the proliferative ability of each tissue cell in the body is not the same. If it cannot be repaired by the same kind of cells, fibroblasts and other interstitial cells will proliferate to repair tissue defects. Although this repair method can maintain the integrity of the tissue and organ structure, it is often accompanied by varying degrees of fibrosis and scar formation, resulting in narrowing of hollow organs and lumens and affecting the normal physiological functions of the human body. For benign strictures...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/10A61L31/08A61L31/14A61L31/16A61L29/08A61L29/14A61L29/16A61L29/02A61L29/06A61L29/04
CPCA61L31/10A61L31/08A61L31/14A61L31/16A61L29/085A61L29/08A61L29/14A61L29/16A61L29/02A61L29/06A61L29/041A61L2300/602A61L2300/606A61L2300/40A61L2400/18A61L2420/02A61L2420/06A61L2300/252A61L2300/254C08L89/00C08L5/08C08L5/04C08L1/286C08L75/04C08L33/12
Inventor 种铁杨鹏
Owner SECOND AFFILIATED HOSPITAL OF COLLEGE OF MEDICINEOF XIAN JIAOTONG UNIV