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Oral antibacterial composition as well as oral care solution prepared from same and application

A technology of oral care solution and composition, which is applied in the field of medicine, can solve problems such as oral microecological imbalance, failure to prevent oral diseases, and Candida albicans infection, and achieve the effects of reducing the number, improving the oral microenvironment, and caring for health

Inactive Publication Date: 2020-11-03
HAOYIKANG BIOLOGICAL TECH(GUANGZHOU) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The reason why oral care products such as toothpaste and oral care solution can achieve these functions is mainly due to the active ingredients or antibacterial ingredients in the product, but these antibacterial ingredients are mostly chemical antibacterial agents (such as triclosan, cetylpyridinium chloride, etc.) , chlorhexidine, antibiotics, etc.), frequent use of oral care products containing these ingredients can easily cause oral microecological imbalance, or cause bacteria to develop drug resistance, fail to achieve the effect of preventing oral diseases, but lead to other oral diseases
[0004] For this, more and more antibacterial toothpaste of Chinese herbal medicine emerges at the historic moment, and the Chinese invention patent of publication number CN105748356A provides a kind of compound recipe Yizhi Artemisia bitter toothpaste containing Chinese herbal medicine composition, is to add Chinese herbal medicine extract to toothpaste paste base and remove However, the strength of the Chinese herbal ingredients in the toothpaste on bacteria generally depends on the concentration of the drug. In addition, the sensitivity of Candida albicans to various Chinese herbal toothpastes is generally low, so long-term use of these toothpastes may cause The risk of Candida albicans infection [Chen Hong, Ding Xi, Zhang Xiuhua, et al. Comparison of the antibacterial potential of five Chinese herbal toothpastes against common oral bacteria[J]. Chinese Journal of Microecology, 2007, 19(004): 351-353. 】
And whether it is a chemical antibacterial agent or an oral care product containing antibacterial components of traditional Chinese medicine, after being sucked into the digestive tract, it may cause certain adverse effects on intestinal microorganisms. Oral products that can effectively inhibit oral pathogenic bacteria and promote oral health

Method used

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  • Oral antibacterial composition as well as oral care solution prepared from same and application
  • Oral antibacterial composition as well as oral care solution prepared from same and application
  • Oral antibacterial composition as well as oral care solution prepared from same and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1 oral antibacterial composition formula

[0036] This example provides a series of formulations of oral antibacterial compositions, which are formed by mixing the components shown in Table 1.

[0037] Table 1

[0038] combination Lysozyme (g) FOS (g) Rice Germ Extract (g) Recipe 1 0.5 1.5 3 Recipe 2 0.5 2 5 Recipe 3 1 1.5 3 Recipe 4 0.2 1.5 1 Recipe 5 0.2 1 1 Recipe 6 0.5 2 - Recipe 7 - 2 5 Recipe 8 0.5 - 5

Embodiment 2

[0039] Embodiment 2 antibacterial composition formula antibacterial activity experiment

[0040] 1. Antibacterial test method

[0041] According to 7.3 of QB 2738-2012 "Evaluation Method for Antibacterial and Antibacterial Effects of Daily Chemical Products" as the detection basis, to detect Streptococcus mutans, Porphyromonas gingivalis, Staphylococcus aureus, Escherichia coli, Candida albicans, common The inhibition rate of bacteria etc. is an investigation index, and the bacteriostasis effect of different bacteriostatic composition formulas among the embodiment 1 is evaluated. The specific operation method is as follows:

[0042] (1) Dilute Streptococcus mutans, Porphyromonas gingivalis, Staphylococcus aureus, Escherichia coli, Candida albicans, Prevotella intermedium and other bacteria with PBS (0.03mol / L phosphate buffer) solution to concentration 1×10 4 ~9×10 4 cfu / mL;

[0043] (2) Dilute the test sample to the specified concentration with sterile standard hard water;...

Embodiment 3

[0057] Embodiment 3 oral care liquid

[0058] 1. Raw materials

[0059] The ingredients of oral care solutions with different ratios are shown in Table 3.

[0060] table 3

[0061]

[0062]

[0063] 2. Preparation method of oral care solution

[0064] S1. Preparation of water-soluble components of group A: add humectant, foaming agent, sweetener, fructooligosaccharide, rice germ extract, water, and stir for 10-50 minutes;

[0065] S2. Preparation of oil-soluble components in group B: add solubilizer and essence, and stir for 10-50 minutes;

[0066] S3. Add group B to group A, stir for 10-50 minutes to obtain AB mixture;

[0067] S4. Add lysozyme into the fully mixed AB mixture, and stir for 10-50 minutes to obtain oral care solutions 1-9.

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Abstract

The invention discloses an oral antibacterial composition and an oral care product prepared from the same. The oral antibacterial composition comprises lysozyme, fructo-oligosaccharide and a rice germextract, wherein the lysozyme is compounded with the fructo-oligosaccharide and the rice germ extract, the number of oral pathogenic bacteria can be remarkably reduced, and a new choice is provided for development of oral antibacterial products; the composition is further used for preparing an oral care solution, and the obtained care solution product has a relatively strong bacteriostatic effecton streptococcus mutans, porphyromonas gingivalis, staphylococcus aureus, escherichia coli, candida albicans, prevotella intermedia and the like, so that bacteria are prevented from generating drug resistance, the oral microenvironment is improved. The oral care product is free from chemical antibacterial drug components and fluorine, can significantly proliferate beneficial bacteria of intestinal tracts after being continuously used, and is especially beneficial to healthy development of bodies of children.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an oral antibacterial composition and an oral care solution prepared therefrom. Background technique [0002] According to the results of the "Fourth National Oral Health Epidemiological Survey", the caries prevalence rate of 5-year-old children in my country is as high as 70.9%, and that of 12-year-old children is as high as 34.5%. Among the oral diseases, 55.2% of primary and middle school students experienced oral diseases, and the rate of seeking medical treatment was only 26.4%, which fully shows that the current national oral health problems are very urgent. As we all know, young children are an important period for dental development, and ensuring the oral health of young children is the key to their healthy growth. The main ingredient of current children's toothpaste is based on adult toothpaste. Children's oral mucosa has poor ability to resist external stimuli, and t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/47A61P1/02A61P31/04A61P31/10A61K8/9794A61K8/60A61K8/66A61Q11/00A61Q17/00A61K31/702A61K36/899
CPCA61K8/60A61K8/66A61K31/702A61K36/899A61K38/47A61K2800/592A61Q11/00A61Q17/005A61K8/9794A61P1/02A61P31/04A61P31/10C12Y302/01017A61K2300/00Y02A50/30
Inventor 徐天生褚夫江耿帅峰欧阳学琭李婷魏炜炜
Owner HAOYIKANG BIOLOGICAL TECH(GUANGZHOU) CO LTD
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