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Imidazole-4,5-dicarboxylic acid modified nitrogen-doped carbon quantum dot nano composite material as well as preparation method and application

A technology of nanocomposite materials and carbon quantum dots, which is applied in the field of imidazole 4,5-dicarboxylic acid modified nitrogen-doped carbon quantum dot nanocomposite materials and preparation, can solve the problems of poor sensitivity and time-consuming of microbial detection, and achieves The effect of strong reversibility and good fluorescence response

Pending Publication Date: 2020-11-03
XIANYANG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In general, HPLC and LC-MS methods are expensive, require a dedicated operator, and microbial detection has poor sensitivity and is time-consuming

Method used

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  • Imidazole-4,5-dicarboxylic acid modified nitrogen-doped carbon quantum dot nano composite material as well as preparation method and application
  • Imidazole-4,5-dicarboxylic acid modified nitrogen-doped carbon quantum dot nano composite material as well as preparation method and application
  • Imidazole-4,5-dicarboxylic acid modified nitrogen-doped carbon quantum dot nano composite material as well as preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0044] A preparation method of imidazole 4,5-dicarboxylic acid modified nitrogen-doped carbon quantum dot nanocomposite material, the preparation route is as follows figure 1 shown, including the following steps:

[0045] S1. Preparation of carbon quantum dots

[0046] Wash the wheat straw and crush it into powder with a pulverizer, dry it in an oven at 80°C for 6 hours, and set aside; prepare a 3mol / L sodium hydroxide solution, and accurately pipette 35mL into a small beaker and add 0.5g of the above-mentioned dried wheat straw. Stir the straw powder continuously for 10mins, pour the solution into a polytetrafluoroethylene-lined high-temperature reactor with a flow rate of 50mL, and put it into a drying oven, adjust the temperature to 250°C for 10h; then wait for the reactor to cool to room temperature and Take out the sample, ultrasonicate it for 30mins, and filter to obtain carbon quantum dots with a concentration of 0.08mol / L;

[0047] S2. Preparation of nitrogen-doped c...

Embodiment 2

[0052] A preparation method of imidazole 4,5-dicarboxylic acid modified nitrogen-doped carbon quantum dot nanocomposite material, the preparation route is as follows figure 1 shown, including the following steps:

[0053] S1. Preparation of carbon quantum dots

[0054] Wash the wheat straw and crush it into powder with a pulverizer, dry it in an oven at 60°C for 8 hours, and set it aside. Prepare 2.5mol / L sodium hydroxide solution, and accurately pipette 40mL into a small beaker, add 0.5g of the above-mentioned dried wheat straw powder and continue stirring for 10mins, pour the solution into a Teflon liner with a flow rate of 50mL Put the high-temperature reaction kettle into the drying oven, adjust the temperature to 240°C and continue for 12 hours; then wait for the reaction kettle to cool down to room temperature and take out the sample, ultrasonicate it for 30mins, and obtain carbon quantum dots after filtration;

[0055] S2. Preparation of nitrogen-doped carbon quantum ...

Embodiment 3

[0061] A preparation method of imidazole 4,5-dicarboxylic acid modified nitrogen-doped carbon quantum dot nanocomposite material, the preparation route is as follows figure 1 shown, including the following steps:

[0062] Wash the wheat straw and crush it into powder with a pulverizer, dry it in an oven at 90°C for 8 hours, and set it aside. Prepare 3.5mol / L sodium hydroxide solution, and accurately pipette 30mL into a small beaker, add 0.5g of the above-mentioned dried wheat straw powder and continue stirring for 10mins, pour the solution into a polytetrafluoroethylene liner with a flow rate of 50mL Put the high-temperature reaction kettle into the drying oven, adjust the temperature to 260°C and continue for 8 hours; then wait for the reaction kettle to cool to room temperature and take out the sample, ultrasonicate it for 30mins, and obtain carbon quantum dots after filtration;

[0063] S2. Preparation of nitrogen-doped carbon quantum dots

[0064] Mix the carbon quantum ...

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Abstract

The invention discloses a preparation method of an imidazole-4,5-dicarboxylic acid modified nitrogen-doped carbon quantum dot nano composite material, and belongs to the technical field of nano composite materials. The preparation method comprises the following steps: S1, preparing carbon quantum dots; S2, preparing nitrogen-doped carbon quantum dots; and S3, preparing imidazole-4,5-dicarboxylic acid modified nitrogen-doped carbon quantum dots, namely reacting the nitrogen-doped carbon quantum dots obtained in the S2 with imidazole-4,5-dicarboxylic acid in a molar ratio of (3-1): 1 under an ultrasonic condition to obtain a solution of the imidazole-4,5-dicarboxylic acid modified nitrogen-doped carbon quantum dots. The imidazole-4,5-dicarboxylic acid modified nitrogen-doped carbon quantum dots are synthesized by utilizing the interaction of nitrogen in the nitrogen-doped carbon quantum dots and carboxyl in imidazole-4,5-dicarboxylic acid, the modified carbon quantum dots have good fluorescence response to gentamicin sulfate, and fluorescence is enhanced along with the increase of the concentration of gentamicin sulfate. Moreover, the fluorescence behavior of the quantum dots has very strong reversibility, and the quantum dots are expected to be capable of well detecting gentamicin.

Description

technical field [0001] The invention belongs to the technical field of nanocomposite materials, and in particular relates to an imidazole 4,5-dicarboxylic acid modified nitrogen-doped carbon quantum dot nanocomposite material, a preparation method and application thereof. Background technique [0002] Frequent use of antibiotics will lead to drug resistance, harms such as imbalance of flora in the body, and may also have certain toxicity. For example, penicillin may cause shock or even death, so antibiotics must be used sparingly or even not at all. Aminoglycoside antibiotics are named because their molecular structure has an aminocyclic alcohol and one or more aminosugar quanta, which are connected by sugar bonds to form glycosides. Most of them are polar compounds, easily soluble in water, not easily absorbed in the gastrointestinal tract, and generally require injection. [0003] Gentamicin (GEN) is one of the most widely used aminoglycoside antibiotics, especially for i...

Claims

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Application Information

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IPC IPC(8): C09K11/06C09K11/02C09K11/65B82Y30/00B82Y40/00G01N21/64
CPCC09K11/06C09K11/025C09K11/65B82Y30/00B82Y40/00G01N21/6428C09K2211/1044Y02A50/30
Inventor 王珊高奕红尚永辉赵维古元梓张知侠曹蕾
Owner XIANYANG NORMAL UNIV
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