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Acid-base regulation solution used for dialysate regeneration and dialysate regeneration method

A technology of acid-base adjustment and dialysate, applied in the field of hemodialysis, can solve problems such as excessive fluctuation of bicarbonate ion concentration, achieve the effect of simplifying the control unit and ensuring the quality of dialysis

Active Publication Date: 2020-11-17
RES CENT FOR ECO ENVIRONMENTAL SCI THE CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The embodiment of the present invention provides an acid-base adjustment solution and a dialysate regeneration method for dialysate regeneration, which are used to solve the defect of excessive fluctuation of bicarbonate ion concentration in the regenerated dialysate in the prior art, and realize effective regulation of regeneration dialysis The acid-base balance of the liquid, and control the bicarbonate ion concentration and carbon dioxide partial pressure within a reasonable range

Method used

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  • Acid-base regulation solution used for dialysate regeneration and dialysate regeneration method
  • Acid-base regulation solution used for dialysate regeneration and dialysate regeneration method
  • Acid-base regulation solution used for dialysate regeneration and dialysate regeneration method

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Experimental program
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Effect test

Embodiment 1

[0051] Embodiment 1: B liquid (acid-base adjustment liquid) is the aqueous solution of 6% sodium carbonate+1% sodium hydroxide

[0052] use as figure 1 As shown in the dialysate regeneration system, a simulated dialysate regeneration cycle test was carried out. details as follows:

[0053] Take 4L of simulated liquid, add 8g of urea to it, stir evenly, place it in arterial blood end 1 to simulate arterial blood, and flow into arterial jug 2 through the blood pump, set the blood pump flow rate to 150mL / min, and flow from inlet 3 to arterial jug 2 Continuously replenish urea solution (150mg / mL, total amount 100mL), and set the flow rate of the peristaltic pump to 0.5mL / min.

[0054] The blood flows from the arterial jug 2 into the dialyzer 4, and undergoes material exchange with the dialysate. The flow rate of the dialysate is 300mL / min. After the material exchange, the blood flows into the venous jug 5, and returns to the venous blood end after passing through the gas detecto...

Embodiment 2

[0061] Embodiment 2: B liquid is the aqueous solution of 2% sodium carbonate+1% sodium hydroxide

[0062] Adopt the same flow process as embodiment 1 to carry out the simulated dialysate regeneration cycle test, the difference is:

[0063] Take 4L of simulated solution, add 8g of urea to it, stir evenly, and place it on the arterial blood side. Set blood pump flow rate to 200mL / min, dialysate flow rate to 300mL / min, and treat for 240 minutes. After starting the treatment, a peristaltic pump was used to continuously supplement the blood end with urea solution (150 mg / mL, total 100 mL) at a flow rate of 0.5 mL / min. Imported dialysate samples were taken, and changes in bicarbonate ions and partial pressure of carbon dioxide were measured using a blood gas analyzer (Radiometer, ABL80).

[0064] The result is as Figure 4 and Figure 5 As can be seen from the figure, when the aqueous solution of 1% sodium hydroxide and 2% sodium carbonate is used as liquid B, the pH of the dial...

Embodiment 3

[0065] Embodiment 3: B liquid is the aqueous solution of 1.2% sodium carbonate+2% sodium hydroxide

[0066] Adopt the same flow process as embodiment 1 to carry out the simulated dialysate regeneration cycle test, the difference is:

[0067] Take 4L of simulated solution, add 8g of urea to it, stir evenly, and place it on the blood side. Set blood pump flow rate to 200mL / min, dialysate flow rate to 300mL / min, and treat for 240 minutes. After starting the treatment, a peristaltic pump was used to continuously supplement the blood end with urea solution (150 mg / mL, total 100 mL) at a flow rate of 0.5 mL / min. Imported dialysate samples were taken, and changes in bicarbonate ions and partial pressure of carbon dioxide were measured using a blood gas analyzer (Radiometer, ABL80).

[0068] The result is as Figure 6 and Figure 7 As can be seen from the figure, when the aqueous solution of 2% sodium hydroxide and 1.2% sodium carbonate is used as liquid B, the pH of the dialysate...

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Abstract

The invention provides an acid-base regulation solution used for dialysate regeneration and a dialysate regeneration method. The acid-base regulation solution used for dialysate regeneration is an aqueous solution containing sodium carbonate and sodium hydroxide. According to the acid-base regulation solution used for dialysate regeneration provided by the embodiment of the invention, the aqueoussolution containing the sodium carbonate and the sodium hydroxide is employed instead of a traditional sodium bicarbonate solution, thus helping the acid-base balance of regenerated dialysate to be regulated, and the concentration of bicarbonate ions and the partial pressure of carbon dioxide are controlled within a reasonable range, thus guaranteeing the dialysis quality, and simplifying a control unit of an instrument.

Description

technical field [0001] The invention relates to the field of hemodialysis, in particular to an acid-base regulating solution and a dialysate regeneration method for dialysate regeneration. Background technique [0002] The acid-base balance, ion balance, and bicarbonate concentration of the dialysate have an important impact on the quality of dialysis. Among them, bicarbonate is an important component in human tissue fluid, which is of great significance to maintaining the body's acid-base balance. Serum HCO 3 - It is an important buffer system in plasma and an important indicator for judging the acid-base imbalance in the body. It plays a very important role in the treatment of respiratory acidosis and chronic respiratory alkalosis. A low bicarbonate concentration can cause acidosis in the patient, and a high bicarbonate concentration can cause alkalosis, which poses a great risk to the patient's health. During hemodialysis, controlling the concentration of bicarbonate ...

Claims

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Application Information

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IPC IPC(8): A61M1/16A61M1/36
CPCA61M1/1656A61M1/1696A61M1/36A61M1/3679
Inventor 李建中胡悦琛刘自军
Owner RES CENT FOR ECO ENVIRONMENTAL SCI THE CHINESE ACAD OF SCI
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