Blue light-emitting antibacterial carbon dots as well as preparation method and application thereof

A carbon dot, blue technology, applied in the field of blue luminescent antibacterial carbon dots and its preparation, can solve the problems of toxicity, reduced stability, complicated preparation process, etc., and achieves simple preparation method, low cytotoxicity, and blood compatibility. Good results

Active Publication Date: 2020-11-17
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Abstract
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  • Application Information

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Problems solved by technology

Usually, carbon dots are coupled with substances with antibacterial functions (such as antibiotics, silicon dioxide, nano-silver, etc.) to achieve bacterial imaging and

Method used

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  • Blue light-emitting antibacterial carbon dots as well as preparation method and application thereof
  • Blue light-emitting antibacterial carbon dots as well as preparation method and application thereof
  • Blue light-emitting antibacterial carbon dots as well as preparation method and application thereof

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preparation example Construction

[0026] Some embodiments of the present invention provide a preparation method of blue-emitting antibacterial carbon dots, which includes: preparing carbon dots by heating a carbon source, wherein the carbon source is protamine sulfate.

[0027] Most methods in the prior art are to couple carbon dots with substances with antibacterial functions (such as antibiotics, silicon dioxide, nano-silver, etc.) to achieve bacterial imaging and inhibition, but the preparation process is cumbersome, the stability is reduced, and potential Biological toxicity and induction of drug resistance and other issues. In view of these problems, the inventor creatively proposed to prepare carbon dots by specifically selecting protamine sulfate as a carbon source and heating through a lot of research and practice. The preparation method is simple, the raw materials are easy to obtain, and the operation is green and environmentally friendly. The chromoluminescent carbon dots have good water solubility,...

Embodiment 1

[0046] (1) Weigh 0.5 g of protamine sulfate and disperse in 10 mL of ultrapure water, and then sonicate under an ultrasonic instrument to obtain a uniformly dispersed and transparent solution.

[0047] (2) Transfer the transparent solution obtained in step (1) to a microwave reactor, and react at 200°C for 60 minutes to obtain a carbon dot solution, whose fluorescence spectrum is as follows: figure 2 As shown, the fluorescence intensity is strong, and the particle size characterization results are shown in image 3 .

[0048] (3) Put the carbon dot solution obtained in step (2) directly into a 500D dialysis bag for 24 hours of dialysis and then dry to obtain blue luminescent antibacterial carbon dots.

[0049] To dissolve in 0.1mol / LH 2 SO 4 Quinoline sulfate in solution (refractive index (η) 1.33) was used as reference (quantum yield=54%). The quantum yield of carbon dots was calculated by comparing the ratio of fluorescence area (Ex=360nm) to absorbance. All samples ar...

Embodiment 2

[0054] (1) Weigh 0.1 g of protamine sulfate and disperse in 10 mL of ultrapure water, and then sonicate under an ultrasonic instrument to obtain a uniformly dispersed and transparent solution.

[0055] (2) Transfer the transparent solution obtained in step (1) to a microwave reactor, and react at 180°C for 50 minutes to obtain a carbon dot solution, whose fluorescence spectrum is as follows: figure 2 As shown, the fluorescence intensity is weaker than that of Example 1.

[0056] (3) Put the carbon dot solution obtained in step (2) directly into a 500D dialysis bag for 24 hours of dialysis and then dry to obtain blue luminescent antibacterial carbon dots.

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Abstract

The invention discloses a blue light-emitting antibacterial carbon dot and a preparation method and application thereof. The preparation method comprises the steps that a carbon source is subjected toa heating reaction to prepare the carbon dot, wherein the carbon source comprises protamine sulfate. In the method, the protamine sulfate is specifically selected as a carbon source to be heated to prepare the carbon dots, the blue light-emitting carbon dots capable of imaging and inhibiting bacteria at the same time can be synthesized through a one-step method, and the preparation method is simple. In addition, the blue light-emitting carbon dot is good in water solubility, stable in photochemical property, low in cytotoxicity and good in blood compatibility. Therefore, the antibacterial carbon dot has a wide application prospect in the field of dual functions of bacterial therapy and imaging.

Description

technical field [0001] The invention relates to the technical field of nanomaterials, in particular to a blue luminescent antibacterial carbon dot and its preparation method and application. Background technique [0002] Bacterial infection is one of the global challenges facing human health. With the increasing resistance of bacteria to antibiotics, the research of new antibacterial drugs has become more and more urgent. Cationic conjugated polymers, noble metal nanoparticles, carbon nanotubes and TiO compared with conventional antibiotics 2 A series of nanoparticles such as nanoparticles have good antibacterial function. However, these antibacterial materials also have disadvantages such as strong biotoxicity and low degradability, causing secondary pollution and threats. [0003] In recent years, due to the advantages of high biocompatibility, simple preparation, and good water solubility, carbon dots have made good progress in the field of biomedicine. As an antibact...

Claims

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Application Information

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IPC IPC(8): C09K11/65C01B32/05A61K49/00A61K33/44A61P31/04B82Y40/00
CPCC09K11/65C01B32/05A61K49/0019A61K33/44A61P31/04B82Y40/00Y02A50/30
Inventor 赵丹刘雪梅郝健
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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