Preparation and application of a whitening and freckle-removing composition
A whitening and freckle-removing and composition technology, applied in the field of cosmetic production, can solve the problems of poor stability of kojic acid, aggravated skin pigment, easy oxidation, etc. Effect
Active Publication Date: 2022-05-03
北京耐确生化技术研究所
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Problems solved by technology
However, due to the poor stability of kojic acid, it is sensitive to light and heat, and it is easy to interact with metal ions such as Fe 3+ Chelate, easy to oxidize and change color. On this basis, many derivatives of kojic acid, such as kojic acid palmitate, have been developed to overcome the above defects
However, we have observed that external use of creams containing its derivatives may aggravate skin pigmentation in the early stage and gradually fade after half a month. This may cause new confusion for consumers who have just started using it.
Method used
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Embodiment 1()、 and Embodiment 2
[0014] [Example 1 (essence), and Example 2 (emulsion)]
[0015] Information such as manufacturers and article numbers of some raw materials in the composition described in the embodiments of the present invention are as follows:
[0016]
[0017]
[0018] 1), SOD, MDA content determination
[0019] SOD was determined by riboflavin-nitrotetrazolium blue kit. MDA was determined by thiobarbituric acid (TBA) kit.
[0020] Grouping, modeling and administration process are: 50 guinea pigs are randomly divided into blank group, model group, positive control group (using 2% hydroquinone cream), embodiment 1 group, embodiment 2 group, totally 5 groups, There are 10 animals in each group. And 3 cm × 3 cm skin was taken from the back of guinea pigs in each group for depilation once a week. Except for the blank group, the other groups were irradiated once a day with medium-wave ultraviolet light with a wavelength of 320nm, and the irradiation time was 60 minutes each time. The d...
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The invention belongs to the technical field of cosmetics, and in particular relates to the preparation and application of a whitening and freckle-removing composition. The composition with the function of whitening and removing freckles is mainly composed of the following raw materials in terms of weight percentage: 0.1-5.0% of pomelo (CITRUS GRANDIS) fruit extract, 0.1-6.0% of mugwort leaf (ARTEMISIA ARGYI) extract, ABT-2600 amino acid whitening 0.5‑5.0%, SP‑1 whitening and repairing element (INCI name: soluble proteoglycan) 0.1‑5.0%, EHC‑8 (INCI name: palmitoyl keratin amino acids) 0.5‑5.0%. The whitening and freckle-removing composition provided by the present invention can significantly increase the content of SOD in skin tissue, reduce the content of MDA, reduce the activity of melanocytes, and reduce the generation of melanin particles in the skin, that is, to significantly reduce the content of melanin in the skin, whiten and remove freckles The effect.
Description
technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to the preparation and application of a whitening and freckle-removing composition. Background technique [0002] Whitening, smooth and delicate skin has always been the goal pursued by Asian women, especially Chinese women. In recent years, with the improvement of our people's desire to pursue a better life, women's whitening and freckle cosmetics are in the ascendant and have become the best-selling products in the market. The current global cosmetics sales data also shows that Africans, African Americans, Asians and other colored groups in urban areas of various countries have a further significant increase in demand for such whitening and freckle-removing products. [0003] Current medical research shows that: when skin pigmentation occurs, not only will skin melanocytes produce a large number of melanosomes, but the body will also reduce superoxide dismutase (Sup...
Claims
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IPC IPC(8): A61K8/9789A61K8/44A61K8/73A61K8/65A61Q19/02
CPCA61K8/9789A61K8/44A61K8/73A61K8/65A61Q19/02A61K2800/78
Inventor 刘毅叶小蓉刘平刘铮林虹杉
Owner 北京耐确生化技术研究所