Preparation method of photosensitive antibacterial material

A photosensitive antibacterial and photosensitizer technology, applied in botany equipment and methods, chemicals for biological control, animal repellants, etc., can solve the problems of limited antibacterial effect, achieve short diffusion distance, small damage, and responsive The effect of mild conditions

Inactive Publication Date: 2020-12-04
FUZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Aiming at the problem of limited antibacterial effect of existing antibacterial materials, the present invention provides a method for preparing a photosensitive antibacterial material. The photosensitive antibacterial material is prepared from a photosensitizer and zinc oxide nanoparticles, and utilizes the strong mutual promotion between the two, The obtained material can exert excellent antibacterial effect, and its preparation method is simple and suitable for industrial production

Method used

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  • Preparation method of photosensitive antibacterial material

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: Preparation of zinc phthalocyanine-nanometer zinc oxide photosensitive antibacterial material

[0023] 1. Zinc oxide nanoparticles are prepared by pre-precipitation technology: in this technology, under constant speed stirring conditions, 0.05mol zinc nitrate is completely dissolved in 50mL distilled water at room temperature and continued to stir for 3 hours, and then added to the solution Ammonium hydroxide was slowly added dropwise until the white precipitate was no longer formed; then the pH was adjusted to 9, and after stirring for 3 hours, the precipitate was washed 4 times with distilled water to reduce the pH of the filtrate to 7, and then boiled for 10 minutes, and finally in Calcining at 500°C for 1 hour to obtain zinc oxide nanoparticles;

[0024] 2. Dissolve β-monocarboxyl substituted zinc phthalocyanine in DMSO to make a solution with a concentration of 50μuM, then take 10ml, add 10mg of zinc oxide nanoparticles, ultrasonicate for 5 minutes an...

Embodiment 2

[0025] Embodiment 2: antibacterial performance test

[0026] The experimental strains were Gram-positive Staphylococcus aureus (ATCC 6358) and Gram-negative Escherichia coli (ATCC 8739). Adaptive adjustments are made to the requirements of the test, and the specific steps are as follows:

[0027] The zinc phthalocyanine-nanometer zinc oxide photosensitive antibacterial material (sample 1) and nano zinc oxide (sample 2) prepared in Example 1 were diluted with PBS to a ZnO concentration of 100 mg / L respectively, and the zinc phthalocyanine (sample 3 ) was diluted with PBS until the concentration of zinc phthalocyanine was consistent with the concentration of zinc phthalocyanine in (sample 1), then 20 μl of each sample solution and PBS (control) were added to a 96-well plate, and then 180 μl of bacterial solution was added (10 6 -10 8 CFU / ml), then incubate in a 37°C incubator for 1 hour, then use sterile PBS to dilute each group into different concentration gradients, take 10...

Embodiment 3

[0032] Example 3: Detection of Active Oxygen Generation Ability

[0033] Get the zinc phthalocyanine-nano zinc oxide photosensitive antibacterial material (sample 1), nano zinc oxide (sample 2), zinc phthalocyanine (sample 3) prepared in Example 1, through quantitative determination and the zinc phthalocyanine in sample 1 Consistent concentration) and PBS (control) 20 μL each into a 96-well plate, then add 180 μL of PBS each, and add active oxygen detection reagent, and then each group is irradiated with a light source with a wavelength of 670nm and a power of 25mw, and the detection is performed every 1 minute. Solution fluorescence intensity. The experiment was repeated 3 times.

[0034] The result is as figure 2 It can be seen that the active oxygen generation ability of zinc phthalocyanine-nano-zinc oxide photosensitive antibacterial material is much higher than that of zinc phthalocyanine and nano-zinc oxide.

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Abstract

The invention discloses a preparation method of a photosensitive antibacterial material, and the photosensitive antibacterial material is prepared by enriching a photosensitizer with carboxyl on the surfaces of zinc oxide nanoparticles through a strong adsorption effect by adopting a precipitation method. The photosensitive antibacterial material can generate a large amount of active oxygen through light irradiation, so that the photosensitive antibacterial material has very strong antibacterial performance, is simple in preparation process, relatively mild in reaction condition and suitable for industrial production, and can be used for preparing medical antibacterial materials or building coating materials.

Description

technical field [0001] The invention belongs to the technical field of new functional materials, and in particular relates to a preparation method of a photosensitive antibacterial material. Background technique [0002] In the long river of history, we have caused countless casualties and high economic losses due to the invasion of bacteria and viruses. For the past 60 years, antimicrobials have been considered the panacea for community or nosocomial infections. In fact, antimicrobial resistance (AMR) is now a threat to all of humanity. Governments and the World Health Organization (WHO) have recognized the urgency of addressing AMR and the importance of a global collaborative effort to address this challenge. Therefore, it is urgent to solve the problem of drug-resistant bacterial infection. [0003] Recently, The Lancet magazine proposed that photodynamic antimicrobial therapy can be used as an effective bactericidal therapy (Wainwright et al. “Photoantimicrobials—are ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N59/16A01N59/00A01P1/00A61L2/08
CPCA01N59/00A01N59/16A61L2/084A61L2/088
Inventor 陈静怡黄明东袁彩江龙光
Owner FUZHOU UNIV
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