A kind of in situ injection jelly and its preparation method and application

Abstract

The invention relates to an in-situ injection jelly as well as a preparation method and application thereof. The in-situ injection jelly comprises a first component, a second component and a diluent,wherein the first component is plant polysaccharide, and the second component is amino acid, salt or derivative thereof or micromolecular protein; the mass ratio of the first component to the second component is (200-500): (1-100); and optionally, a third component high polymer material is further included. The in-situ injection jelly can be directly injected under mucous membranes to achieve theeffect of bulging a diseased region, has the advantages of long maintenance time, high bulging degree and difficulty in deformation under compression, is not prone to flowing out after the diseased region is excised, can still be maintained in situ, and achieves the effects of stopping bleeding and promoting wound healing.

Description

technical field [0001] The invention relates to the field of medical polymer materials, in particular to an in-situ injection jelly and its preparation method and application. Background technique [0002] With the continuous development of digestive endoscopy technology, endoscopic treatment of gastrointestinal diseases has become more and more popular. From polypectomy in 1968 to endoscopic mucosal resection (EMR) in the 1980s, treatment techniques have become more and more mature. Endoscopic mucosal resection is a method of removing polyps or small tumors formed on the mucosa of the digestive tract such as the stomach or intestines without laparotomy under the endoscope. Since the mucosal lesion does not protrude clearly, and the mucosal surface is easy to slip, when the lesion is removed by remote operation while performing an endoscopic examination, there are corresponding technical difficulties, and there may be residual lesion and / or Risk of serious events such as b...

AI Technical Summary

Problems solved by technology

[0005] Physiological saline: It is an isotonic liquid, it is difficult to maintain the ideal height, it is quickly absorbed by the surrounding tissues, the maintenance time is only a few minutes, and repeated injections are required, and the injection volume is large

[0006] Hypertonic saline or hypertonic glucose: Due to the high osmotic pressure, it can maintain a relatively ideal height for a long time, but it is easy to deform when applying pressure to the raised part

[0007] Sodium hyaluronate: It has high viscosity and water retention, and the uplift time is significantly better than that of hypertonic solution, which can better ensure the complete resection of lesions, but it is expensive and requires stricter storage conditions

[0008] In addition, the current submucosal injection materials generally have the following shortcomings: strong fluidity, limited maintenance time; insufficient bulge height; easy to deform when pressure is applied to the bulge; after the lesion is excised, the submucosal injection material flows out and interferes with the field of view And it is not conducive to hemostasis; since the submucosal injection material flows out after a certain lesion is resected, continuous resection of multiple adjacent lesions cannot be performed unless a hemostatic clip is used

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