Freeze-dried powder preparation for preventing and improving fundus macular degeneration and preparation method thereof

A technology for freeze-dried powder and macular disease, which is applied in freeze-dried delivery, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. effect of care

Inactive Publication Date: 2020-12-08
上海旷世医疗管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, there are not many daily care products used today, and freeze-dried powder daily care products ...

Method used

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  • Freeze-dried powder preparation for preventing and improving fundus macular degeneration and preparation method thereof
  • Freeze-dried powder preparation for preventing and improving fundus macular degeneration and preparation method thereof
  • Freeze-dried powder preparation for preventing and improving fundus macular degeneration and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0085] As a specific technical solution, the second aspect of the present invention provides a method for preparing the above-mentioned lyophilized powder preparation, including the preparation of the lyophilized powder and the preparation of the vehicle. Proceed as follows:

[0086] S1. Preparation of freeze-dried powder:

[0087] (1) Stir and dissolve the preparation raw materials of the freeze-dried powder evenly;

[0088] (2) after the sampling test is qualified, filter the discharge to obtain the lyophilized liquid;

[0089] (3) Take the freeze-dried liquid for physical, chemical and microbiological index inspection, quantitatively fill 1.5mL / bottle or 2mL / bottle into cleaned and sterilized 5mL or 10mL vials, and put them into plates and half-stoppered, then put into freeze dryer;

[0090] (4) freeze-drying process parameters are set, and the freeze-drying machine is started;

[0091] (5) Pre-cooling, freezing the lyophilized liquid;

[0092] (6) heat up, and dry and...

Embodiment 1

[0128] Embodiment 1 provides a kind of freeze-dried powder preparation that is used for the prevention and improvement of fundus macular disease, is made of two parts of freeze-dried powder and solvent solution, and its composition of mass percent is respectively:

[0129] Freeze-dried powder: based on the total mass percentage of freeze-dried powder, including sodium hyaluronate 0.03%, lutein 0.01%, riboflavin 0.01%, pyridoxine 0.05%, cyanocobalamin 0.05%, lactoferrin 0.5% %, oligopeptide-1 0.0005%, oligopeptide-50.0005-%, mannitol 3.0%, sodium chondroitin sulfate 0.03%, hydrogenated lecithin 0.1%, deionized water balance;

[0130] Solvent solution: based on the total mass percentage of the solvent solution, including 0.1% taurine, 0.5% sweetophylline, 0.05% dipotassium glycyrrhizinate, 0.03% polysorbate-80, 0.01% sodium chloride, and 0.01% lysozyme , Deionized water balance;

[0131] The packaging quality of the freeze-dried powder is 0.15g, and the solvent solution is 5mL;...

Embodiment 2

[0150] Embodiment 2 provides a kind of freeze-dried powder preparation that is used for the prevention and improvement of fundus macular disease, is made up of two parts of freeze-dried powder and solvent liquid, and its composition of mass percent is respectively:

[0151] Freeze-dried powder: based on the total mass percentage of freeze-dried powder, including sodium hyaluronate 0.04%, lutein 0.02%, riboflavin (vitamin B2) 0.01%, pyridoxine (vitamin B6) 0.06%, cyanocobalamin Ammonium (vitamin B12) 0.06%, lactoferrin 0.8%, oligopeptide-1 0.0007%, oligopeptide-5 0.0006%, mannitol 3.5%, sodium chondroitin sulfate 0.03%, hydrogenated lecithin 0.15%, deionized water margin;

[0152] Solvent solution: based on the total mass percentage of the solvent solution, including 0.15% taurine, 0.8% sweetophylline, 0.08% dipotassium glycyrrhizinate, 0.04% polysorbate-80, 0.02% sodium chloride, and 0.015% lysozyme , Deionized water balance;

[0153] The packaging quality of the freeze-drie...

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Abstract

The invention belongs to the technical field of eye care products, and particularly relates to a freeze-dried powder preparation for preventing and improving fundus macular degeneration. The freeze-dried powder preparation is composed of freeze-dried powder and solvent liquid, wherein the freeze-dried powder comprises sodium hyaluronate, xanthophyll, riboflavin, pyridoxine, cyanocobalamin, lactoferrin, oligopeptide-1, oligopeptide-5, mannitol, sodium chondroitin sulfate, hydrogenated lecithin and deionized water, and the solvent liquid comprises taurine, bataine, dipotassium glycyrrhizinate, polysorbate-80, sodium chloride, lysozyme and deionized water. The invention further provides a preparation method of the freeze-dried powder preparation. The freeze-dried powder preparation prepared by using the preparation method is used for carrying out daily nutrition maintenance and cell injury repair on all organ functions of eyes, is safe and non-irritant, and has obvious effects on fundus macular conditions, such as visual deformation, macular disorder, middle-aged and elderly melasma acuminatum and senile macular deformation.

Description

technical field [0001] The invention belongs to the technical field of eye care products, and in particular relates to a freeze-dried powder preparation and a preparation method for preventing and improving fundus macular disease. Background technique [0002] Fundus macular disease is a common ophthalmic disease. It is caused by lesions in the retinal macular area of ​​the fundus, resulting in decreased vision, dark shadows in front of the eyes, or metamorphopsia, blurring and other symptoms. Ophthalmoscopy can clearly see the vitreous body of the eye macula, so it is called macular disease. Macular disease can be caused by heredity, age, inflammation, etc., and the age of onset is 10-50 years old. However, the data show that the incidence of young people has shown a sharp upward trend, which is mainly related to the "eye fatigue" caused by modern networked work, mobile phone culture, overtime, staying up late and other factors. "Eye fatigue" will inevitably lead to dehyd...

Claims

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Application Information

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IPC IPC(8): A61K38/40A61K9/19A61K47/24A61K47/26A61K47/36A61P27/02A61K31/047A61K31/4415A61K31/525A61K31/714A61K31/728A61K38/16
CPCA61K9/19A61K31/047A61K31/4415A61K31/525A61K31/714A61K31/728A61K38/16A61K38/40A61K47/24A61K47/26A61K47/36A61P27/02A61K2300/00
Inventor 唐亚雷
Owner 上海旷世医疗管理有限公司
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