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Tetrandrine liposome, preparation method thereof and medical mask containing tetrandrine liposome

A technology of tetrandrine and alkali lipids, which is applied to chemicals, applications, and protective clothing for biological control. It can solve the problems of low encapsulation efficiency and drug loading, and achieve high drug loading and encapsulation efficiency. High, enhanced protective effect

Active Publication Date: 2020-12-11
北京理工大学重庆创新中心 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] One of the objectives of the present invention is to provide a tetrandrine liposome with high encapsulation efficiency and drug loading capacity, which solves the problem of low encapsulation efficiency and drug loading capacity of tetrandrine liposomes in the prior art

Method used

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  • Tetrandrine liposome, preparation method thereof and medical mask containing tetrandrine liposome
  • Tetrandrine liposome, preparation method thereof and medical mask containing tetrandrine liposome
  • Tetrandrine liposome, preparation method thereof and medical mask containing tetrandrine liposome

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Effect test

Embodiment 1

[0054] The present embodiment discloses the preparation method of the tetrandrine liposome of the present invention, specifically as follows:

[0055]Weigh soybean lecithin (0.36g), cholesterol (0.036g), Tween-80 (0.072g), and tetrandrine (0.03g) respectively, add absolute ethanol (15mL) to fully dissolve, remove the solvent by evaporation under reduced pressure, in A uniform film is formed on the bottom of the bottle. Add pH 6.5 phosphate buffer (30 mL), and hydrate at 30° C. for 15 minutes to obtain liposome colostrum. Then through 500bar high-pressure homogenization three times, each homogenization time is 32s, namely the tetrandrine liposome solution. The measured particle size is 327.2nm (PDI=0.558), the potential is 3.93mV, the encapsulation efficiency is 83.13%, and the drug loading is 6.17%.

[0056] The tetrandrine liposomes prepared in this example have Tyndall effect and nanometer size. as attached figure 1 As shown, there will be a light path when the tetrandri...

Embodiment 2

[0059] The present embodiment discloses the preparation method of the tetrandrine liposome of the present invention, specifically as follows:

[0060] Weigh soybean lecithin (0.36g), oleic acid (0.154g), cholesterol (0.036g), Tween-80 (0.072g), tetrandrine (0.03g), add absolute ethanol (30mL) to fully dissolve, The solvent was removed by evaporation under reduced pressure, and a uniform film was formed on the bottom of the bottle. Add pH 6.5 phosphate buffer (30 mL), and hydrate at 30° C. for 15 minutes to obtain liposome colostrum. Then through 500bar high-pressure homogenization three times, each homogenization time is 32s, namely the tetrandrine liposome solution. The measured particle size is 119.72nm (PDI=0.225), the potential is -23.3mV, the encapsulation efficiency is 98.79%, and the drug loading is 4.09%.

Embodiment 3

[0062] The present embodiment discloses the preparation method of the tetrandrine liposome of the present invention, specifically as follows:

[0063] Weigh soybean lecithin (0.36g), oleic acid (0.154g), cholesterol (0.036g), Tween-80 (0.072g), tetrandrine (0.06g), add absolute ethanol (30mL) to fully dissolve, The solvent was removed by evaporation under reduced pressure, and a uniform film was formed on the bottom of the bottle. Add pH 6.5 phosphate buffer (30 mL), and hydrate at 30° C. for 15 minutes to obtain liposome colostrum. Then through 500bar high-pressure homogenization three times, each homogenization time is 32s, namely the tetrandrine liposome solution. The measured particle size is 182.9nm (PDI=0.099), the potential is -16.1mV, the encapsulation efficiency is 98.62%, and the drug loading is 9.06%.

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Abstract

The invention discloses tetrandrine lipidosome, a preparation method thereof and a medical mask containing the tetrandrine lipidosome, and belongs to the technical field of medicines and medical instruments. The tetrandrine lipidosome is prepared from tetrandrine, soyabean lecithin, cholesterol, Tween 80 and oleic acid according to a certain weight ratio. The preparation method comprises the stepsof dissolving the raw materials in absolute ethyl alcohol, and removing the solvent by reduced pressure evaporation to form a uniform film at the bottom of a container; adding a buffer salt solution,and hydrating to obtain lipidosome primary emulsion; and carrying out high-pressure homogenization on the primary emulsion to obtain the tetrandrine lipidosome. According to the medical mask disclosed by the invention, tetrandrine lipidosome is attached to the inner-layer filter material melt-blown cloth. The tetrandrine lipidosome prepared by the invention is high in encapsulation efficiency, large in drug loading capacity, good in stability and uniform in particle size, and capable of enhancing the protection function of the mask and prolonging the service life of the mask when being applied to the medical mask.

Description

technical field [0001] The invention belongs to the technical field of drugs and medical devices, and in particular relates to tetrandrine liposome, its preparation method, and a medical mask containing it. Background technique [0002] Tetrandrine (TET), also known as tetrandrine, is a bisbenzylisoquinoline alkaloid extracted from Tetrandrine (Stephania tetrandra S. Moore). Tetrandrine has a wide range of pharmacological effects, and it is commonly used clinically in the treatment of arthritis, silicosis, hypertension, tumors, prevention and treatment of liver fibrosis, protection of liver cells, antibacterial, antiviral, etc. Tetrandrine has strong lipophilicity and is easily soluble in organic solvents such as ethanol and acetone and dilute acid water, but its solubility in water is poor, its molecular weight is large, it is not easy to be absorbed, its bioavailability is very low and its curative effect is unstable, which greatly limits its clinical application. [000...

Claims

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Application Information

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IPC IPC(8): A01N43/90A01N25/30A01P1/00A41D13/11
CPCA01N25/30A01N43/90A41D13/1192
Inventor 石三军苏岳峰陈来尹平喻姣罗苏兰刘利娟向南希
Owner 北京理工大学重庆创新中心
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