Paracetamol tablet and preparation process thereof

A technology of acetaminophen and acetaminophen, which is applied in the field of acetaminophen tablets and its preparation process, can solve the problems of decomposition of functional components and reduction of drug efficacy, and achieve the effect of avoiding decomposition or failure and strong drug action

Pending Publication Date: 2020-12-15
安徽金太阳生化药业有限公司
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  • Abstract
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Problems solved by technology

[0003] At present, there are many preparation processes for acetaminophen tablets on the market, but in the existing preparation process, the mixing a

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  • Paracetamol tablet and preparation process thereof

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[0026]The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work shall fall within the protection scope of the present invention.

[0027]In the description of the present invention, it should be understood that the terms "opening", "upper", "lower", "thickness", "top", "middle", "length", "inner", "around", etc. The indication of the orientation or position relationship is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the component or element referred to must have a specific orientation...

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Abstract

The invention discloses a paracetamol tablet and a preparation process thereof, and belongs to the field of paracetamol tablets. The preparation process of the paracetamol tablet comprises the following steps: firstly, preparing raw materials of a medicine; uniformly stirring corn starch and lauryl sodium sulfate, and adding the mixture into boiling water to obtain mixed slurry with the concentration of 16%; putting paracetamol, low-substituted hydroxypropyl cellulose, pregelatinized starch, sucrose and carboxymethyl starch sodium into a mixer, and stirring and mixing the materials; then adding the mixed slurry to prepare a soft medicine material; putting the soft material into a swing type granulator for granulation to prepare medicine granules; drying the medicine granules; and putting lauryl sodium sulfate, magnesium stearate, carboxymethyl starch sodium and lauryl sodium sulfate into the mixer, then adding the medicine granules, and performing secondary mixing in the mixer.

Description

technical field [0001] The invention relates to the field of paracetamol tablets, in particular to a paracetamol tablet and a preparation process thereof. Background technique [0002] Acetaminophen (Paracetamol), also known as Tylenol, Panadol, Bufferin, and paracetamol. This product is the in vivo metabolite of phenacetin, which can regulate central prostaglandin synthase by inhibiting hypothalamic body temperature. Reduce the synthesis and release of prostaglandins PGE1, bradykinin and histamine. PGE1 mainly acts on the nerve center, and its reduction will lead to a decrease in the temperature setting point of the center, and the temperature receptors on the body surface will feel relatively hot, and then cause peripheral blood vessels to dilate and sweat through nerve regulation to achieve antipyretic effect, which inhibits the central nervous system The effect of prostaglandin synthesis is similar to that of aspirin, but the anti-inflammatory effect is weaker. No eff...

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Application Information

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IPC IPC(8): A61K9/20A61K31/167A61K47/38A61K47/36A61K47/26A61K47/20A61P29/00
CPCA61K31/167A61K9/2059A61K9/2054A61K9/2018A61K9/2095A61K9/2013A61P29/00
Inventor 强泽明徐三能张强
Owner 安徽金太阳生化药业有限公司
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