Etodolac ionic salt as well as preparation method and application thereof

A technology of etodolac and ionic salts, applied in the field of pharmaceutical and cosmetic compounds, can solve the problems of staying in the application range, limiting the application effect and application prospect, etc., and achieves the effects of improving absorption, good safety and high purity
CN112079842APending Publication Date: 2020-12-15HARBIN INST OF TECH SHENZHEN GRADUATE SCHOOL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HARBIN INST OF TECH SHENZHEN GRADUATE SCHOOL
Publication Date
2020-12-15

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Abstract

The invention belongs to the field of compounds for medicines and cosmetics, and discloses etodolac ionic salt as well as a preparation method and application thereof. The cations of the etodolac ionsalt are formed by alkaloid, and anions of the etodolac ion salt are formed by etodolac. The preparation method of the etodolac ion salt comprises the following steps: (1) in an inert gas atmosphere,adding etodolac and alkaloid into an organic solvent, and carrying out an ionization modification reaction to prepare an etodolac ion salt solution; and (2) concentrating the etodolac ion salt solution prepared in the step (1) under a vacuum condition, and freeze-drying to obtain the etodolac ion salt The etodolac ion salt completely retains main molecular skeletons and functional groups of cations and anions, has biological activities and effects of the two substances, and shows a good anti-inflammatory effect, water solubility and low cytotoxicity.
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Description

technical field

[0001] The invention belongs to the field of medicine and cosmetic compounds, and in particular relates to an etodolac ion salt and a preparation method and application thereof. Background technique

[0002] Etodolac is an indole acetic acid non-steroidal anti-inflammatory drug with strong analgesic effect. Clinically, it is widely used to relieve the symptoms of rheumatoid arthritis and osteoarthritis, delay the bone pathological changes caused by arthritis, and is also used for the treatment of postoperative pain. The common mechanism of action of NSAIDs is to inhibit the activity of cyclooxygenase-2 (COX-2) and reduce the biosynthesis of prostaglandins at the site of inflammation, thereby controlling inflammation and relieving pain. In addition, etodolac has good oral absorption, does not produce obvious accumulation effect under multiple doses, has no persistent effect on liver and kidney functions, and has good safety and tolerance. But at present, the...

Claims

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