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Application of special amino acid derivative in preparing preparation for preventing and controlling African swine fever

A technology of derivatives and amino acids, applied in the direction of antiviral agents, drug combinations, medical preparations with non-active ingredients, etc., can solve the problems of no effective vaccine for preventing African swine fever, change of owner risk pig farms, impacts, etc., to achieve Effects of preventing digestion and absorption, prolonging shelf life, and reducing feeding frequency

Inactive Publication Date: 2020-12-18
河南佰景生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the first outbreak of African swine fever in my country in early August 2018, the disease has spread throughout China in just one year, and no province has been spared. The loss is in the trillions. Some group companies are affected by this and face the risk of changing owners, and most pig farms are burdened with huge debts. This has brought a heavy blow to my country's pig breeding industry and the national economy, and has caused nearly 100 million employees in the upstream and downstream of the pig farming industry. serious impact on personnel
[0004] Unfortunately, there is no effective vaccine to prevent African swine fever in the world so far, and the specific medicine that can be used to treat African swine fever is still in the laboratory stage. The infection threshold of African swine fever virus is one of the important means to prevent and control African swine fever

Method used

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  • Application of special amino acid derivative in preparing preparation for preventing and controlling African swine fever
  • Application of special amino acid derivative in preparing preparation for preventing and controlling African swine fever
  • Application of special amino acid derivative in preparing preparation for preventing and controlling African swine fever

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preparation example Construction

[0052] The preparation process of chitosan theanine derivatives described in the present application is shown in the following formula (2).

[0053]

[0054] The specific steps of the process for preparing chitosan theanine derivatives include:

[0055] 1) Dissolve theanine in a sufficient amount of distilled water, adjust the pH of the solution to 9-10, stir and reflux at a temperature of 45-50°C, slowly add epichlorohydrin which is equimolar to theanine, and react until the solution is completely clear Dehydration and recrystallization with acetone, washing with absolute ethanol at least 5 times, and drying to obtain theanine epichlorohydrin intermediate;

[0056] 2) Add chitosan with a high degree of deacetylation that is dried to constant weight into 10-15 times by weight of isopropanol, stir and make it fully swell for at least 4 hours, and then add 15-30 times the weight of chitosan for hydrogen oxidation Sodium solution, mix well and place at 5-10°C for at least 48 ...

Embodiment 1

[0072] The present embodiment provides a chitosan theanine derivative:

[0073] 1) Dissolve 1.72g (0.01mol) theanine in 50g distilled water, adjust the pH to 10 with 20% sodium hydroxide solution, stir and reflux at 300r / min at 50°C, slowly add 0.01mol dropwise at a rate of 10mL / min Epichlorohydrin, reacted until the solution was completely clear, dehydrated and recrystallized with acetone, washed 5 times with absolute ethanol, and dried in vacuum at 50°C to constant weight to obtain 2.48g of theanine epichlorohydrin intermediate, with a yield of 86.1 %;

[0074] 2) Add 413.3g of chitosan (deacetylation degree 100%, weight average molecular weight 100000) dried to constant weight into 4200g of isopropanol, stir at 600r / min and make it fully swell for 4h, then add 8300g of 15% chitosan Sodium hydroxide solution, mix well and place at 10°C for 48 hours;

[0075] 3) ultrafiltration step 2) the fully swollen chitosan, filter out the sodium hydroxide, dissolve in a large amount o...

Embodiment 2

[0077] The present embodiment provides a chitosan theanine derivative:

[0078] 1) with embodiment 1;

[0079] 2) Add 620g of chitosan (deacetylation degree 100%, weight average molecular weight 100000) dried to constant weight into 6500g of isopropanol, stir at 600r / min and make it fully swell for 4h, then add 9300g of 15% hydrogen Sodium oxide solution, mixed evenly and placed at 10°C for 48 hours;

[0080] 3) Obtain chitosan theanine derivatives with Example 1, that is, the weight ratio of chitosan and theanine epichlorohydrin intermediate is 100:0.4.

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Abstract

The invention relates to the technical field of preparations for preventing and controlling African swine fever, in particular relates to application of a special amino acid derivative in preparing apreparation for preventing and controlling African swine fever, and specifically provides application of a preparation containing a chitosan theanine derivative and gamma-polyglutamic acid in preventing and controlling of African swine fever. The immune function of the piglets can be effectively enhanced, the infection threshold of the piglets to the African swine fever viruses is increased, the infection opportunity of the African swine fever is reduced, the death rate of infected pigs is remarkably reduced, rapid spreading of African swine fever conditions is inhibited, and the purposes of delaying disease outbreak and relieving the disease progress are achieved.

Description

technical field [0001] The invention relates to the technical field of preparations for preventing and controlling African swine fever, in particular to the application of a special amino acid derivative in the preparation of preparations for preventing and controlling African swine fever. Background technique [0002] African swine fever (Infection with African swine fever virus, ASF) is caused by African swine fever virus (African swine fever virus, ASFV) infecting domestic pigs and various wild boars (such as African wild boar, European wild boar, etc.) Hemorrhagic and severe infectious diseases. The World Organization for Animal Health (OIE) listed it as a legally notifiable animal disease, and this disease is also a class of animal epidemics that my country focuses on preventing. It is characterized by a short course of disease, the most acute and acute infection mortality rate is as high as 100%, clinical manifestations are fever (up to 40-42 ℃), rapid heartbeat, dysp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/722A61K31/198A61K31/785A61K47/69A61P31/20A61P37/04
CPCA61K31/198A61K31/722A61K31/785A61K47/6951A61P31/20A61P37/04A61K2300/00
Inventor 焦现民
Owner 河南佰景生物科技有限公司
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