Device for saponifying and extracting ergosterol

An ergosterol and saponification technology, which is applied in organic chemistry, steroids, solid solvent extraction, etc., can solve the problems of long extraction process, high energy consumption, complex operation of saponification and extraction of ergosterol, etc.

Pending Publication Date: 2020-12-22
内蒙古麦维生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patented extraction process is long and energy-consuming, and the operation of the device for saponification and extraction of ergosterol is complicated

Method used

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  • Device for saponifying and extracting ergosterol
  • Device for saponifying and extracting ergosterol
  • Device for saponifying and extracting ergosterol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] (1) Extraction: weigh 1kg of penicillin fermentation bacteria residue, add it to the extraction tank, add 1.2kg of methanol, maintain the temperature at 55°C by heating, add 70g of solid sodium hydroxide, stir for 6 hours, then add 1.2kg of petroleum ether, heat The temperature was maintained at 50°C and stirred for 3 hours.

[0086] (2) Filtration and phase separation: the material after the extraction reaction in step (1) is subjected to vacuum filtration, the filtrate is collected, the filtrate is pumped into the phase separation tank and left to stand for stratification, the upper layer light phase liquid is collected, and the lower layer solvent is recovered. At the same time, 0.5kg of filter cake was collected.

[0087] (3) decolorization and crystallization: add the upper layer liquid collected in step (2) filtration and phase separation into the decolorization tank with stirring device, maintain the temperature at 50 ° C, add 1 g of activated carbon, stir for 2 ...

Embodiment 2

[0090] (1) Extraction: weigh 1kg of penicillin fermentation bacteria residue, add it to the extraction tank, add 1.2kg of methanol, maintain the temperature at 55°C by heating, add 70g of solid sodium hydroxide, stir for 6 hours, then add 1.2kg of petroleum ether, heat The temperature was maintained at 50°C and stirred for 3 hours.

[0091] (2) Filtration and phase separation: the material after the extraction reaction in step (1) is subjected to vacuum filtration, the filtrate is collected, the filtrate is pumped into a phase separation tank and left to stand for stratification, the upper layer light phase liquid is collected, and the lower layer solvent is recovered. At the same time, 0.5kg of filter cake was collected.

[0092] (3) 2 extractions of filter cake: add the petroleum ether of 0.6kg in the extraction tank, then add the filter cake 0.5kg generated after step (2) filtration and phase separation; be warming up to 50 ° C, stir, maintain temperature and extract for 2 ...

Embodiment 3

[0097] (1) Extraction: Weigh 1 kg of penicillin fermentation bacteria residue, add it to the extraction tank, add 1.2 kg of chloroform, heat to maintain the temperature at 57° C., add 50 g of sodium hydroxide, and stir for 4 hours. 1.2 kg of n-heptane was added, the temperature was maintained at 50° C. by heating, and the mixture was stirred for 3 hours.

[0098] (2) Filtration and phase separation: the material after the extraction reaction in step (1) is subjected to vacuum filtration, the filtrate is collected, the filtrate is pumped into the phase separation tank and left to stand for stratification, the upper layer light phase liquid is collected, and the lower layer solvent is recovered.

[0099] (3) decolorization and crystallization: add the upper layer light phase liquid collected in step (2) filtration and phase separation into a decolorization tank with a stirring device, be warming up to 60 ° C, add 1 g of activated carbon, stir for 2 hours, and use vacuum extractio...

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Abstract

The invention discloses a device for saponifying and extracting ergosterol, which comprises an extraction tank. The extraction tank comprises an upper cylindrical barrel and a lower conical barrel which are connected up and down, a feeding port is formed in the top of the extraction tank, a discharging port is formed in the bottom of the extraction tank, and a stirring device is arranged in the center of the extraction tank; and a flow baffle is arranged on the inner wall of the extraction tank. The method has the advantages of simplified extraction process, short extraction time, low energy consumption in the extraction process, high product purity and the like.

Description

technical field [0001] The invention belongs to the field of pharmaceutical intermediates, in particular to a device for saponifying and extracting ergosterol from fermentation bacteria residue. Background technique [0002] Ergosterol is also known as ergosterol. Ergosterol is an important part of microbial cell membranes and plays an important role in ensuring the integrity of cell membranes, the activity of membrane-bound enzymes, membrane fluidity, cell viability, and cellular material transport. Ergosterol is a precursor for the production of vitamin D2 and an intermediate for the production of hormone drugs, which can be used to produce cortisone. Has the effect of vitamin D2. [0003] The traditional ergosterol synthesis method is mainly based on microbial fermentation supplemented by traditional chemical synthesis and separation, and its production process route starts from ERG9 to prepare ergosterol. The high cost leads to high product prices and insufficient mar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D11/02B01J19/18B01D36/00C07J9/00
CPCB01D11/02B01J19/18B01J19/0053B01D36/00C07J9/00
Inventor 潘桀杨东泽官鑫熙王涛李磊
Owner 内蒙古麦维生物科技有限公司
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