Simulated moving bed chromatography method for separating cresol isomeride mixture

Abstract

The invention aims to solve the problem that a cresol isomeride mixture is difficult to separate by taking MOFs as a stationary phase of SMB, and provides a simulated moving bed chromatography methodfor separating the cresol isomeride mixture. MOFs are high in specific surface area and developed in pore structure, and have excellent adsorption separation performance. According to the method, MOFsformed by Fe<3+> and terephthalic acid (H2BDC) are used as a stationary phase, the mixed xylene isomer is separated by using a simulated moving bed at normal temperature, the purity of the xylene monomer is 95-100%, the yield is 90-100%, especially for the separation of p-cresol and m-cresol, the purity of p-cresol can be purified from 80% to 100%, and the yield is 98.2%. The number of chromatographic columns used in the process is small, efficient separation can be carried out in a 2-1-1 mode (three-zone SMB, I-zone independence and four chromatographic columns), elution is carried out through a low-boiling-point mobile phase, SMB separation is carried out at the normal temperature, energy is saved, and equipment is simple.

Description

technical field

[0001] The invention belongs to the technical field of adsorption separation, in particular to a simulated moving bed chromatography for separating cresol mixtures. Background technique

[0002] Cresol includes three isomers of p-cresol, m-cresol and o-cresol, all of which are important fine chemical intermediates for the preparation of pesticides, medicines, spices, dyes, antioxidants, synthetic vitamin E, Synthetic resins, coloring materials, developers, fluorescent whitening agents, liquid crystal materials, gasoline additives and edible oil preservatives, etc. In order to meet different purposes, high-purity cresol monomer is required.

[0003] Most of the products obtained by natural separation and chemical synthesis are mixtures of cresol isomers, and to obtain cresol monomer needs to be separated from other cresol isomers. The boiling points of o / p / m-cresol are 190.8°C, 202.5°C and 202.8°C, respectively. Ortho-cresol can be separated by rectificatio...