Disulfiram-based glucan nanometer prodrug, and preparation method and application thereof
A nano-drug, dextran technology, applied in the field of polymers, can solve the problems of limiting the clinical application of disulfiram, fast metabolism, poor stability, etc., and achieve the effects of low cost, good hydrophilicity, and good biocompatibility
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Embodiment 1
[0034] In this example, see figure 1 and image 3 , a method for preparing disulfiram-based dextran nano drug prodrugs, the steps are as follows:
[0035] (1) Preparation of side chain hydroxylated dextran:
[0036] Weigh 1g of dextran and 200mg of LiCl into a 100mL three-necked flask and place it in a vacuum drying oven, set the temperature at 75°C, and dry under vacuum for 72h; after the drying, add 10mL of anhydrous N , in N-dimethylformamide (DMF) and set the temperature of the oil bath to 90°C and stir until the liquid is clear; remove the oil bath after the liquid is clear, place it in an ice bath after standing to cool, and slowly and continuously pass nitrogen protection, Then add 0.59 mL of pyridine, so that the amount of pyridine is twice the molar amount of phenyl p-nitrochloroformate, then add 0.75 mg of phenyl p-nitrochloroformate in batches, and react under ice bath conditions (0°C) for 24 hours; The amount of phenyl p-nitrochloroformate is calculated based on...
Embodiment 2
[0053] This embodiment is basically the same as Embodiment 1, especially in that:
[0054] In this example, see figure 1 and image 3 , a method for preparing disulfiram-based dextran nano drug prodrugs, the steps are as follows:
[0055] (1) Preparation of side chain hydroxylated dextran:
[0056] Weigh 5g of dextran and 200mg of LiCl into a 100mL three-necked flask and place it in a vacuum drying oven, set the temperature at 75°C, and dry it under vacuum for 72h; after the drying, add 10mL of anhydrous N , in N-dimethylformamide (DMF) and set the temperature of the oil bath to 90°C and stir until the liquid is clear; remove the oil bath after the liquid is clear, place it in an ice bath after standing to cool, and slowly and continuously pass nitrogen protection, Subsequently, 1.18 mL of pyridine was added, so that the amount of pyridine was twice the molar amount of phenyl p-nitrochloroformate, and then 1.5 mg of phenyl p-nitrochloroformate was added in batches, and the ...
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