Long-acting liquid gel containing rose essential oil as well as preparation method and application of long-acting liquid gel

A rose essential oil and gel technology, applied in the field of medicine, can solve the problems such as wound healing of rose essential oil, no ulcers and other inflammatory injuries, and achieve the effects of promoting wound healing, relieving wound pain, and resisting external stimuli.

Active Publication Date: 2021-01-08
SHAOXING UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing cosmetics with rose essential oil as the main active ingredient in the market are lotions, creams, perfumes, etc., which are mainly used to enhance the smell of the product, moisturize skin care and improve the mood of the user, but so far, no rose essential oil can promote According to research reports on wound healing, there is no long-acting in-situ slow-controlled release rose essential oil gel product that can treat ulcers and other inflammatory injuries.

Method used

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  • Long-acting liquid gel containing rose essential oil as well as preparation method and application of long-acting liquid gel
  • Long-acting liquid gel containing rose essential oil as well as preparation method and application of long-acting liquid gel
  • Long-acting liquid gel containing rose essential oil as well as preparation method and application of long-acting liquid gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032]Example 1 Liquid gel preparation process

[0033]According to the formulation of the liquid gel formulation of the present invention, polyglycerol fatty acid ester (PG) / soya phospholipid (PC) / rose essential oil (REO) / ethanol (EtOH)=48 / 32 / 10 / 10 (mass ratio). First, accurately weigh the prescription amount of PC, PG and 25% of the final liquid gel volume of medicinal ethanol (EtOH), place them in a round-bottomed flask, seal them, and incubate them on a constant temperature water bath magnetic stirrer at 100 rpm and 40°C. , Until PC and PG are completely dissolved to prepare a homogeneous and clear solution A of PC / PG / EtOH, the concentration of (PC+PG) in A can be adjusted to 200~1000mg·mL according to need-1, Preferably 500~1000mg·mL-1, More preferably 750~950mg·mL-1; Next, use a rotary evaporator (vacuum, 40 ℃, 1h) to remove all or almost all EtOH from solution A to obtain liquid mixture B. The residual amount of EtOH in B shall not be greater than 0.1%, otherwise the liquid gel ...

Embodiment 2

[0034]Example 2 Investigation of the influence of PC / PG ratio on the formation of liquid gel

[0035]Through prescription screening and optimization, various liquid crystal phases (L2, I2, HII , Lɑ ), according to the method of Example 1, prepare a liquid gel preparation containing different proportions of phosphatidylcholine (PC) and polyglycerol fatty acid ester (PG) and using EtOH as an organic solvent. After balancing with excess water, different The liquid crystal phase.

[0036]Table 1 Investigation of the influence of PC / PG ratio on the formation of liquid gel

[0037]

[0038]a.q. = solution state

[0039]L2= Reverse cubic phase

[0040]I2= Reverse cubic liquid crystal phase

[0041]HII = Anti-hexagonal liquid crystal phase

[0042]Lɑ =Lamellar crystal phase

Embodiment 3

[0043]Example 3 Investigation of the influence of different PC types on the formation of liquid gel

[0044]According to the method described in Example 1, liquid gel formulations with different types of PC were prepared. The final liquid gel formulation contained 32.7% PC, 55.5% PG, 10% EtOH and 1.8% REO in mass ratio, balanced with excess water Later, different liquid crystal phases can be obtained, but all contain I2phase.

[0045]Table 2 Investigation of the influence of different PC types on the formation of liquid gel

[0046]

[0047]

[0048]Remarks:

[0049]1. Soy phospholipids: Lipoid company, S100 series, in which the PC content is greater than 94%;

[0050]2. Egg yolk phospholipids: EPCS series from Lipoid, Germany, with PC content greater than 96%;

[0051]3. Ditrans oleoylphosphatidylcholine, dioleoylphosphatidylethanolamine, dioleoylphosphatidylglycerol, dioleoylphosphatidylserine, dioleoylphosphatidylinositol and other phospholipids were purchased from Avanti, USA. The purity is greater tha...

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Abstract

The invention provides long-acting liquid gel containing rose essential oil as well as a preparation method and application of the long-acting liquid gel. The liquid gel contains phospholipid (PC), polyglycerol fatty acid ester (PG), rose essential oil (REO) and an organic solvent. The long-acting liquid gel for treating oral trauma (especially oral ulcer) provided by the invention has the advantages that firstly, the liquid gel is low-viscosity flowing liquid before being used, and high-viscosity gel is formed when the liquid gel meets an aqueous solution after being used, so that the liquidgel is convenient to fill and use in a local cavity of a human body, and the lasting action time is long; secondly, the liquid gel disclosed by the invention is rich in natural rose essential oil, isfused with various polyglycerol derivatives as raw materials, is free of immunogenicity and good in biodegradability, and has the effects of promoting wound healing, relieving wound pain and further recovering and maintaining the natural elasticity of the skin; and thirdly, the liquid gel does not contain any preservative, but the validity period is longer than 3 years, and the product performanceis not changed within 5 years.

Description

Technical field[0001]The invention belongs to the technical field of medicine, and particularly relates to a long-acting liquid gel containing rose essential oil and a preparation method and application thereof.Background technique[0002]For conventional drug delivery systems, multiple doses can be administered to maintain a high blood drug concentration for a long time. However, for tissue spaces, organ surfaces, joint cavities, oral cavity and other parts, the location is hidden and full of body fluids, and it is almost impossible to administer multiple times in a row, and it is difficult to maintain the problem of blood concentration; and for local diseases, the whole body is not recommended in medicine. Administration for treatment can easily cause adverse reactions. Therefore, there is an urgent need for a long-acting in situ sustained and controlled release pharmaceutical preparation that can be easily operated.[0003]At present, the gel products on the market are generally semi...

Claims

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Application Information

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IPC IPC(8): A61K8/92A61K8/04A61K8/37A61K8/49A61K8/55A61K8/86A61K36/738A61K9/06A61K47/24A61K47/14A61P1/02A61P17/02A61Q17/04A61Q19/00A61Q19/02
CPCA61K8/922A61K8/553A61K8/375A61K8/4993A61K8/86A61K8/042A61Q17/04A61Q19/02A61Q19/00A61K36/738A61K9/06A61K47/24A61K47/14A61P1/02A61P17/02Y02A50/30
Inventor 骆翔陈徐盈高超伟顾华芳徐歌杨继永吕东辉朱柯武沈润溥
Owner SHAOXING UNIVERSITY
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