Long-acting liquid gel containing rose essential oil as well as preparation method and application of long-acting liquid gel
A rose essential oil and gel technology, applied in the field of medicine, can solve the problems such as wound healing of rose essential oil, no ulcers and other inflammatory injuries, and achieve the effects of promoting wound healing, relieving wound pain, and resisting external stimuli.
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Embodiment 1
[0032]Example 1 Liquid gel preparation process
[0033]According to the formulation of the liquid gel formulation of the present invention, polyglycerol fatty acid ester (PG) / soya phospholipid (PC) / rose essential oil (REO) / ethanol (EtOH)=48 / 32 / 10 / 10 (mass ratio). First, accurately weigh the prescription amount of PC, PG and 25% of the final liquid gel volume of medicinal ethanol (EtOH), place them in a round-bottomed flask, seal them, and incubate them on a constant temperature water bath magnetic stirrer at 100 rpm and 40°C. , Until PC and PG are completely dissolved to prepare a homogeneous and clear solution A of PC / PG / EtOH, the concentration of (PC+PG) in A can be adjusted to 200~1000mg·mL according to need-1, Preferably 500~1000mg·mL-1, More preferably 750~950mg·mL-1; Next, use a rotary evaporator (vacuum, 40 ℃, 1h) to remove all or almost all EtOH from solution A to obtain liquid mixture B. The residual amount of EtOH in B shall not be greater than 0.1%, otherwise the liquid gel ...
Embodiment 2
[0034]Example 2 Investigation of the influence of PC / PG ratio on the formation of liquid gel
[0035]Through prescription screening and optimization, various liquid crystal phases (L2, I2, HII , Lɑ ), according to the method of Example 1, prepare a liquid gel preparation containing different proportions of phosphatidylcholine (PC) and polyglycerol fatty acid ester (PG) and using EtOH as an organic solvent. After balancing with excess water, different The liquid crystal phase.
[0036]Table 1 Investigation of the influence of PC / PG ratio on the formation of liquid gel
[0037]
[0038]a.q. = solution state
[0039]L2= Reverse cubic phase
[0040]I2= Reverse cubic liquid crystal phase
[0041]HII = Anti-hexagonal liquid crystal phase
[0042]Lɑ =Lamellar crystal phase
Embodiment 3
[0043]Example 3 Investigation of the influence of different PC types on the formation of liquid gel
[0044]According to the method described in Example 1, liquid gel formulations with different types of PC were prepared. The final liquid gel formulation contained 32.7% PC, 55.5% PG, 10% EtOH and 1.8% REO in mass ratio, balanced with excess water Later, different liquid crystal phases can be obtained, but all contain I2phase.
[0045]Table 2 Investigation of the influence of different PC types on the formation of liquid gel
[0046]
[0047]
[0048]Remarks:
[0049]1. Soy phospholipids: Lipoid company, S100 series, in which the PC content is greater than 94%;
[0050]2. Egg yolk phospholipids: EPCS series from Lipoid, Germany, with PC content greater than 96%;
[0051]3. Ditrans oleoylphosphatidylcholine, dioleoylphosphatidylethanolamine, dioleoylphosphatidylglycerol, dioleoylphosphatidylserine, dioleoylphosphatidylinositol and other phospholipids were purchased from Avanti, USA. The purity is greater tha...
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