A kind of preparation method of small size hollow mesoporous silica nanoparticles

Abstract

The invention discloses a preparation method of small-sized hollow mesoporous silica nanoparticles, which comprises the following steps: adding ammonia water, LiOH aqueous solution, cetyltrimethylammonium bromide, cetyltrimethylammonium bromide into an ethanol aqueous solution After the methyl ammonium bromide is dissolved, add tetraethyl orthosilicate ethanol solution dropwise, stir, filter with a 200nm filter membrane, and finally dry the solid, calcine, and remove impurities to obtain a small-sized hollow mesoporous dioxide with a size less than 30nm. Silicon nanoparticles. The method of the invention has simple operation and high yield, and prepares hollow mesoporous silica nanoparticles. The particle size prepared by the method of the present invention is small (<30 nm), the hollow shape is clear, and the mesopore size distribution is narrow.

Description

technical field [0001] The invention belongs to the technical field of nanomaterial preparation, and in particular relates to a preparation method of small-sized (<30nm) hollow mesoporous silica nanoparticles. [0002] technical background [0003] Hollow mesoporous silica nanoparticles have been widely used as carrier materials for anticancer drugs in recent years due to their high specific surface area, large cavity volume, good stability and biocompatibility. Among them, many in vitro cell experiments and biological activity experiments have found that small-sized hollow mesoporous silica nanoparticles (<50nm) are more conducive to maintaining the circulation and biodistribution of drug molecules in the blood, and are also more efficient. Facilitates the capture of tumor cells (small 2009, 5, 1408–1413). Especially in clinical applications, nanoparticles with smaller size are more beneficial to the metabolic balance of the kidneys, and are also more beneficial to be...

AI Technical Summary

Problems solved by technology

However, the efficient synthesis of small-sized hollow mesoporous silica nanoparticles is always a challenge! Generally, the method of using carbon particles or polymer particles as hard templates can better control the size of hollow mesoporous silica nanoparticles, but the shape of hollow particles is easily destroyed during the template removal process. (Materials Chemistry and Physics 2018,211,123–136); and the soft template method, although the operation is relatively simple, and the template reagent is easier to be removed than the hard template method, but until today, it is still difficult to prepare small-sized (<30nm) Hollow Mesoporous Silica Nanoparticles

Although some people have prepared ultra-small mesoporous silica particles by adding particle growth inhibitors (J.Am.Chem.Soc.2012, 134, 13180-13183), the yield of this type of method is low and the operation is difficult. Troublesome, and the hollow shape is not clear enough, and the distribution of mesopore size is relatively wide, which is not conducive to practical application and large-scale production

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