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Fenbendazole production process and production device

A kind of technology of fenbendazole, production process, applied in the field of fenbendazole production process and production equipment, can solve the problems such as low purity of fenbendazole, low degree of intelligence, waste of reagents, etc., to achieve the improvement of product purity, automation High degree of effect of reducing reagent consumption

Pending Publication Date: 2021-01-12
宁夏大漠药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved in the present invention is to provide a kind of fenbendazole production technique and production device, to solve the problems of fenbendazole low purity, reagent waste, complex process and low degree of intelligence

Method used

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  • Fenbendazole production process and production device
  • Fenbendazole production process and production device
  • Fenbendazole production process and production device

Examples

Experimental program
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Effect test

Embodiment 1

[0036] Such as figure 1 and figure 2 Shown, the fenbendazole production technique of the present embodiment comprises the following steps:

[0037](1) Nitration reaction: Add m-chloroaniline, acid anhydride, glacial acetic acid and sulfuric acid in the nitration reaction kettle, fully stir and mix, then gradually add nitric acid in the nitration reaction kettle, carry out the nitration reaction under stirring, after the reaction finishes, put The mixed solution is transferred to a condensation reaction kettle for solid-liquid separation, then water is added to the solid product for washing, and the washing liquid is separated and treated as waste water to obtain 4-chloro-2-nitroaniline; in the step (1) The nitrification reaction temperature is 10-15°C, and the nitric acid is added within 20 minutes, and the reaction is continued for 3 hours after the addition;

[0038] (2) Condensation reaction: add methanol to the condensation reaction kettle and fully stir and dissolve, t...

Embodiment 2

[0046] Such as figure 1 and figure 2 Shown, the fenbendazole production technique of the present embodiment comprises the following steps:

[0047] (1) Nitration reaction: Add m-chloroaniline, acid anhydride, glacial acetic acid and sulfuric acid in the nitration reaction kettle, fully stir and mix, then gradually add nitric acid in the nitration reaction kettle, carry out the nitration reaction under stirring, after the reaction finishes, put The mixed solution is transferred to a condensation reaction kettle for solid-liquid separation, then water is added to the solid product for washing, and the washing liquid is separated and treated as waste water to obtain 4-chloro-2-nitroaniline; in the step (1) The nitrification reaction temperature is 15-20°C, the nitric acid is added within 25 minutes, and the reaction is continued for 6 hours after the addition is completed; the amount of nitric acid used is m-chloroaniline:nitric acid=1:1.15 in molar ratio.

[0048] (2) Condens...

Embodiment 3

[0057] Such as figure 1 and figure 2 Shown, the fenbendazole production technique of the present embodiment comprises the following steps:

[0058] (1) Nitration reaction: Add m-chloroaniline, acid anhydride, glacial acetic acid and sulfuric acid in the nitration reaction kettle, fully stir and mix, then gradually add nitric acid in the nitration reaction kettle, carry out the nitration reaction under stirring, after the reaction finishes, put The mixed solution is transferred to a condensation reaction kettle for solid-liquid separation, then water is added to the solid product for washing, and the washing liquid is separated and treated as waste water to obtain 4-chloro-2-nitroaniline; in the step (1) The nitrification reaction temperature is 20-25°C, the nitric acid is added within 30 minutes, and the reaction is continued for 10 hours after the addition is completed; the amount of nitric acid used is m-chloroaniline:nitric acid=1:1.2 by molar ratio.

[0059](2) Condensa...

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Abstract

The invention discloses a fenbendazole production process and a production device, the production process comprises a nitration reaction, a condensation reaction, a reduction reaction and a cyclization reaction, and finally the fenbendazole is obtained through centrifugation and drying. The production device comprises a plurality of reaction kettles, a distillation device and a distillation recovery device, the reaction kettles are respectively a nitration reaction kettle, a condensation reaction kettle, a cyclization reaction kettle and a reduction reaction kettle, and the nitration reactionkettle, the condensation reaction kettle, the cyclization reaction kettle, the distillation device and the reduction reaction kettle are sequentially communicated through feeding pipes. According to the process, the product purity can be improved; few types of chemical reagents are adopted, and methanol and methylbenzene are recycled so that reagent consumption is reduced, waste is avoided, and the process is economical and environmentally friendly; the process route is simple, the production period is shortened, and the production efficiency is improved; according to the production device, automatic feeding is achieved through the feeding mechanism, the automation degree is high, manual operation is reduced, and efficiency is improved.

Description

[0001] technology neighborhood [0002] The present invention relates to the neighborhood of medicine production technology, specifically, relate to a kind of fenbendazole production technology and production device. Background technique [0003] Fenbendazole (Fenbendazole) is also known as benzimidazole, and its chemical name is 5-phenylthio-1H-benzimidazole-2-carbamate methyl ester. Fenbendazole is a new type of benzimidazole anthelmintic with broad spectrum, high efficiency and low toxicity. It was successfully developed by Hoechst in the 1970s. Caucus, Dicoela lanceolata, Fasciola and tapeworms are also effective. In foreign countries, fenbendazole is not only used for various animals, but also has special preparations for wild animals. [0004] Fenbendazole is used in the production and processing process, the biggest problem that exists is: 1, fenbendazole impurity content is high, product purity reduces; 2, the chemical reagent type that adopts in the process is many,...

Claims

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Application Information

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IPC IPC(8): C07D235/32
CPCC07D235/32
Inventor 马会利杨咸臣田祖云
Owner 宁夏大漠药业有限公司
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