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Aristolochic acid derivatives and application

A technique for aristolochic acid and derivatives, which is applied to aristolochic acid derivatives and application fields, can solve problems such as agricultural production loss, and achieve the effect of good application prospects

Pending Publication Date: 2021-01-12
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Plant bacterial diseases are an important class of plant diseases, which cause huge losses to agricultural production every year

Method used

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  • Aristolochic acid derivatives and application
  • Aristolochic acid derivatives and application
  • Aristolochic acid derivatives and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Embodiment 1: Determination of antibacterial activity of aristoloxazine C in vitro

[0064] Preparation of antibacterial test sample: take a certain amount of compound, and use 5% (volume fraction) methanol to prepare the compound into a test drug solution with a mass concentration of 100 ppm for antibacterial test.

[0065] Activation culture of bacteria: the test bacteria were taken out from the refrigerator at 4°C, inoculated into centrifuge tubes of LB liquid medium, and activated at 37°C for 12 hours.

[0066] Preparation of bacterial suspension: Take a small amount of activated test bacteria and add it to an appropriate amount of liquid LB medium, incubate at 37°C for 8-12 hours, take 2ml of bacterial suspension in a cuvette to test its absorbance, dilute the bacterial solution to 0.5 μg Turbidity (absorbance at 600nm wavelength is 0.08-0.13), and then diluted 200 times with liquid medium, and mixed. At this time, the concentration of the bacterial solution was a...

Embodiment 2

[0072] Embodiment 2: Aristoloxazine C pot bioactivity assay

[0073] The control of tobacco bacterial wilt is carried out by pot experiment method, and the control of kiwifruit canker is carried out by living tissue method.

[0074] Inoculation of pathogenic bacteria: the activated tobacco bacterial wilt pathogen was set to 10 8 cfu / ml suspension concentration, treatment is 10 8 Tobacco irrigated with cfu / ml bacterial suspension; the test compound aristoloxazine C 500mg / L was treated, and the root irrigation (10mL per pot) was applied; at the same time, an equal amount of LB medium was set as a control, and the treated tobacco was placed in the greenhouse for cultivation.

[0075] Cut the freshly picked kiwi branches into small branches of about 15cm, seal the two ends with wax oil, carry out surface disinfection with 75% ethanol, and after drying, use sterilized high-temperature tweezers to create strip wounds in the middle of the branches, spray to activate after 10 8 The...

Embodiment 3

[0086] Embodiment 3: Aristoloxazine C and other fungicide compound in vitro biological activity assay

[0087] This embodiment adopts counting method to measure, and method is described in embodiment 1. 1 in the sample is Aristoloxazine C, and the concentration is listed as the concentration of aristoloxazine C + the concentration of the compound drug. The results of the antibacterial assay are shown in Table 5. The results showed that the combination of aristoloxazine C and various agents had significant inhibitory effects on several pathogenic bacteria.

[0088] Table 5 Antibacterial effects of Aristoloxazine C and representative fungicides on seven pathogenic bacteria

[0089]

[0090]

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PUM

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Abstract

The invention discloses aristolochic acid derivatives and an application thereof. The specific structure of the aristolochic acid derivatives is shown as a formula (I). The aristolochic acid derivative provided by the invention is separated from the root of an asarum plant and is identified as a new compound through a structure, and experiments prove that the compound has good activity in the field of sterilization, such as common staphylococcus aureus, especially bacterial diseases in agricultural pathogenic bacteria,meanwhile, experiments prove that the compound also has a good application prospect in meat preservation.

Description

technical field [0001] The invention belongs to the field of fungicides, and in particular relates to an aristolochic acid derivative and its application. Background technique [0002] Plant bacterial diseases are an important class of plant diseases, which cause huge losses to agricultural production every year. In order to prevent the occurrence of plant diseases and reduce the losses caused by them, a large number of antibacterial and bactericidal active compounds have been reported and applied. Due to factors such as drug resistance, the research and development of new fungicides has always been the focus of attention of various pesticide companies and researchers. [0003] In recent years, due to the abuse of antibiotics and the development of bacterial drug resistance, the problem of drug resistance in clinical bacterial infections has become more and more serious. Drug-resistant infectious diseases have become the main factor in the death of clinical infectious disea...

Claims

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Application Information

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IPC IPC(8): C07D498/06A01N43/90A01P1/00A61K31/5365A61P31/04A23B7/154A23B4/20
CPCC07D498/06A01N43/90A61P31/04A23B7/154A23B4/20
Inventor 闫合范小静冯俊涛马志卿张兴
Owner NORTHWEST A & F UNIV
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