Double-layer hydrocolloid dressing and preparation method thereof

A hydrocolloid, double-layer technology, applied in medical science, absorbent pads, bandages, etc., can solve problems such as bonding failure of hydrocolloid dressings, increasing family economic burden, prolonging wound healing time, etc., to improve adhesion stability and Strength, excellent adhesion and liquid absorption properties, widely produced and applied effects

Inactive Publication Date: 2021-01-15
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after being in contact with the wound for a period of time, it is inevitable that the adhesive failure and the spontaneous detachment of the hydrocolloid dressing will occur, which will cause a series of problems such as wound infection and prolonged wound healing time, which will further aggravate the patient's pain and increase family financial burden

Method used

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  • Double-layer hydrocolloid dressing and preparation method thereof
  • Double-layer hydrocolloid dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Get 10 parts of styrene-isoprene-styrene block copolymer, 45 parts of rubbery elastomer polybutene, 15 parts of petroleum resin (petroleum resin is C5 petroleum resin and C9 petroleum resin according to the quality of 1:1 (obtained by mixing), 5 parts of naphthenic oil, 10101 parts of antioxidant, put into the twin-screw internal mixer, at 130°C, heat-preserve and banbury for 15min; reduce the temperature of the internal mixer to 80°C, add methylol Continue banburying for 45 parts of sodium cellulose for 20 minutes. The resulting product was pressed at 110°C by a flat vulcanizer to form a 1mm plate, which was used as the lower base material of the double-layer hydrocolloid dressing.

Embodiment 2

[0027] Get 20 parts of styrene-isoprene-styrene block copolymer, 35 parts of rubbery elastomer polyisoprene, 12 parts of petroleum resin (petroleum resin is C5 petroleum resin and C9 petroleum resin by 2:1 The mass ratio is obtained by mixing), 5 parts of naphthenic oil, 10101 parts of antioxidant, put into the twin-screw internal mixer, at 120 ℃ temperature, heat preservation and internal mixing for 20min; reduce the temperature of internal mixer to 100 ℃, add hydroxyl Continue banburying 30 parts of sodium methylcellulose CMC and 5 parts of gelatin for 10 minutes. The obtained product was pressed at 100°C by a flat vulcanizer to form a 1mm plate, which was used as the lower base material of the double-layer hydrocolloid dressing.

Embodiment 3

[0029] Get 25 parts of styrene-isoprene-styrene block copolymer, 30 parts of rubbery elastomer polyisobutylene, 8 parts of petroleum resin (petroleum resin is C5 petroleum resin and C9 petroleum resin by mass ratio of 1:2 Mix to obtain), 5 parts of naphthenic oil, 10101 parts of antioxidant, put into the twin-screw internal mixer, at 140 ℃ temperature, insulation banburying 10min; reduce the temperature of internal mixer to 90 ℃, add hydroxymethyl fiber 20 parts of plain sodium CMC and 10 parts of sodium alginate continued banburying for 15 minutes. The resulting product was pressed at 110°C by a flat vulcanizer to form a 1mm plate, which was used as the lower base material of the double-layer hydrocolloid dressing.

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Abstract

The invention discloses double-layer hydrocolloid dressing and a preparation method thereof. The preparation method mainly comprises the following steps: 1, insulating and mixing a continuous-phase rubber matrix and a hydrophilic-phase hydrocolloid in a double-screw internal mixer to obtain hydrocolloid dressing; 2, pressing the hydrocolloid dressing by using a press vulcanizer to form a lower base material; and 3, coating hydrogel formed by dissolving acrylic acid, gelatin, ketoglutaric acid, methacrylate gelatin and N-hydroxy succinimide in deionized water on the lower base material, and performing curing under ultraviolet light to obtain the double-layer hydrocolloid dressing. The double-layer hydrocolloid dressing has excellent adhesion performance and liquid absorption performance ina wet environment, is compact in combination, cannot be layered after being soaked in a configured wound simulated solution for 24 hours. is non-toxic and harmless on human bodies, has a simple preparation process and relatively low production cost, and can be widely prepared and applied.

Description

technical field [0001] The invention relates to the field of medical hydrocolloid dressings, in particular to a double-layer hydrocolloid dressing and a preparation method thereof. Background technique [0002] Wound dressings, which temporarily act as skin to cover wounds during use, prevent the invasion of bacteria and microorganisms, and can give wounds an environment conducive to healing. Hydrocolloid dressings were proposed and rapidly applied in clinic because of their good performance. Hydrocolloid dressings consist of a lipophilic pressure-sensitive adhesive (continuous phase) and a hydrophilic filler (dispersed phase), which provide self-adhesiveness and good moisture control, respectively, during wound healing. For dressings, viscosity and moisture control are two seemingly contradictory but indispensable properties. Proper humidity can promote wound healing, but excessive secretions around the wound may lead to the proliferation of bacteria and inflammation of t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/24A61L15/32A61L15/40A61L15/60
CPCA61L15/24A61L15/32A61L15/40A61L15/60C08L89/06C08L33/02C08L9/06
Inventor 郝同辉刘婷吴宇张群朝蒋涛
Owner HUBEI UNIV
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