Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of ganoderic acid A and derivatives thereof or lucid ganoderma total triterpenes in preparation of medicines for treating eye diseases

A technology for Ganoderma lucidum total triterpenes and eye diseases, applied in the field of biomedicine, can solve problems such as no cataract, achieve clear effect, high safety, and reduce lacrimal gland and corneal lesions.

Active Publication Date: 2021-01-26
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is still no effective drug treatment for cataract, and surgery is the only treatment at present

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of ganoderic acid A and derivatives thereof or lucid ganoderma total triterpenes in preparation of medicines for treating eye diseases
  • Application of ganoderic acid A and derivatives thereof or lucid ganoderma total triterpenes in preparation of medicines for treating eye diseases
  • Application of ganoderic acid A and derivatives thereof or lucid ganoderma total triterpenes in preparation of medicines for treating eye diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation of embodiment 1 Ganoderma lucidum total triterpenes

[0023] Take Ganoderma lucidum fruiting bodies, dry at 70°C for 6 hours, pulverize, and pass through a No. 3 sieve to obtain coarse powder. Take the coarse powder, put it into the chromatography column, make the column height ratio between 12:1, add 10 times the amount of petroleum ether, soak for 24 hours, collect the seepage, then add 10 times the amount of ethanol and water in turn, and collect the seepage respectively , combined petroleum ether and ethanol leaching seepage; combined seepage through ADS-8 macroporous resin, followed by elution with 20%, 30%, 40%, 50%, 75% and 100% ethanol solution , flow rate 1.5bv, collect the eluent eluted with ethanol with a volume fraction above 50%, and recover the solvent under reduced pressure. Through preparative grade OSD-C18 column, further refine, collect 10 kinds of ganoderma acid (ganoderic acid C, ganoderma acid C2, ganoderma acid G, ganocid acid B, g...

Embodiment 2

[0024] Embodiment 2 pharmacodynamic experiment

[0025] 1. Instruments and reagents

[0026] 1.1 Feed production

[0027] The mouse maintenance feed (Beijing Huafukang Biotechnology Co., Ltd.) was crushed, and the total triterpenes of Ganoderma lucidum and an appropriate amount of water were added, and mixed evenly. The feed contains Ganoderma acid C, Ganoderma acid C2, Ganoderma acid G, Ganoderma acid B, Ganoderma acid B, Ganoderma acid A, Ganoderma acid H, Ganoderma acid D, Ganoderma acid D, Ganoderma acid F, the specific contents are shown in Table 1 , thus obtaining a feed containing total triterpenoids of Ganoderma lucidum.

[0028] Table 1

[0029]

[0030] The maintenance feed for mice (Beijing Huafukang Biotechnology Co., Ltd.) was crushed, and Ganoderma acid A and an appropriate amount of distilled water were added, and mixed evenly. The ganoderma acid A contained in the feed is 0.005 mg per gram of feed, thereby obtaining the ganoderma acid A-containing feed. ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses application of ganoderic acid A and derivatives thereof or lucid ganoderma total triterpenes in preparation of medicines for treating eye diseases. The medicine or functional product composed of ganoderic acid A or a derivative thereof or lucid ganoderma triterpenoids can obviously relieve the tear gland and corneal lesions of naturally aged mice, the metabolic level of thebody is closer to the young state, and the medicine or functional product has the effects of preventing and treating eye diseases such as cataract and eye degenerative changes and the like, and is clear in effect and high in safety.

Description

Technical field: [0001] The invention belongs to the field of biomedicine, and specifically relates to the application of ganoderma acid A and its derivatives or ganoderma total triterpenes in the preparation of medicines for treating eye diseases. Background technique: [0002] Ganoderma lucidum is the dry fruiting body of Ganoderma lucidum (Leyss.ex Fr.) Karst. or Ganoderma sinense Zhao, Xu et Zhang of Polyporaceae. Lung deficiency cough and asthma, fatigue and shortness of breath, not thinking about eating and drinking embolism. In my country, Ganoderma lucidum has been used medicinally for 2,000 years. "Shen Nong's Materia Medica" lists Ganoderma lucidum as the top grade, which has the effects of calming the nerves, improving sleep, and benefiting essence. Pharmacological studies have shown that Ganoderma lucidum triterpenes and polysaccharides are the two main pharmacologically active components of Ganoderma lucidum. Ganoderic acid and ganoderma enoic acid are a class ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/575A61K36/074A61P27/02A61P27/12
CPCA61K31/575A61K36/074A61P27/02A61P27/12
Inventor 王东东陈地灵郭殷锐祁龙凯唐晓萃谢意珍李良秋吴清平
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com